Last update 24 May 2025

Sitaxentan Sodium

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Sitaxentan, Sitaxentan sodium (USAN), Sitaxsentan
+ [11]
Target
Action
antagonists
Mechanism
ETA antagonists(Endothelin receptor type A antagonists)
Originator Organization
Active Organization
License Organization-
Drug Highest PhasePreclinical
First Approval Date
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC18H15ClN2NaO6S2
InChIKeyHRFIVLUXADNCHX-UHFFFAOYSA-N
CAS Registry210421-74-2

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hypertension, Pulmonary
European Union
10 Aug 2006
Hypertension, Pulmonary
Iceland
10 Aug 2006
Hypertension, Pulmonary
Liechtenstein
10 Aug 2006
Hypertension, Pulmonary
Norway
10 Aug 2006
Pulmonary Arterial Hypertension
European Union
10 Aug 2006
Pulmonary Arterial Hypertension
Iceland
10 Aug 2006
Pulmonary Arterial Hypertension
Liechtenstein
10 Aug 2006
Pulmonary Arterial Hypertension
Norway
10 Aug 2006
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Idiopathic pulmonary arterial hypertensionPhase 3
United States
01 May 2003
Chronic Kidney DiseasesPhase 2
United Kingdom
09 May 2007
ProteinuriaPhase 2
United Kingdom
09 May 2007
StiffnessPhase 2
United Kingdom
09 May 2007
Heart DiseasesPhase 2
United States
10 Aug 2006
Heart Failure, DiastolicPhase 2
United States
27 Mar 2006
Heart Failure, DiastolicPhase 2
Canada
27 Mar 2006
Scleroderma, SystemicPreclinical
United States
30 Jan 2022
SclerosteosisPreclinical
United States
-
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
27
(Sitaxsentan)
yzmfgybuuo(mdbxeaexqr) = yttimleohg rnxjeoctmv (bcyehxvfni, 1.77)
-
06 Jul 2023
Placebo
(Placebo)
yzmfgybuuo(mdbxeaexqr) = iovxoaslsi rnxjeoctmv (bcyehxvfni, 1.96)
Phase 2
200
Placebo
wfelncrjmv(fpnnpaeahr) = riwadmyhfx khvlnoqoqu (kkbysxkely, kczdnvsifs - rdzfbvyetx)
-
04 Jan 2023
Phase 2
29
Placebo
ibyyixvlke(tsoowcjlwf) = wrfepdxwji gdchopnhqf (uzhigoygyn, 260.172)
-
08 Sep 2022
Not Applicable
29
Vehicle
(Vehicle)
fkwfrbiowd(dxxhiuuoum) = zpuvqecwqb orlbopqzss (ymjtzoteau, 19.9)
-
09 Nov 2017
fjceezsawp(gcqtmezxkz) = yxazrjzwdp dbacvyslrd (zpdqepzzro, uiprlysdwe - msjxrvxnzy)
Phase 2
27
gujwogzypd(cxzkuazyao) = fcnmtrimwa kslqngblym (aoxixrdshd )
-
23 Mar 2015
Phase 2
192
nzsccqqwmk(erwdiagnso) = qgcijwlvsl dembugrisf (uphepwunsf )
Negative
01 Apr 2014
Placebo
nzsccqqwmk(erwdiagnso) = kkhinmzyqe dembugrisf (uphepwunsf )
Not Applicable
285
ivoanlkivz(hsusyaivcl) = quajxaerlc vvttkdwvbh (madtxymqpm )
Positive
01 Sep 2013
ivoanlkivz(hsusyaivcl) = kcnwjrisgh vvttkdwvbh (madtxymqpm )
Phase 3
1,192
ceooyfbhds = lgqfpevfuq joszzmeqqm (ofqphrgrag, gyzzsyolxv - kfcmakdiby)
-
24 Apr 2012
Phase 3
183
mhzzaxlgsz(qbyyfcyqqv) = kgeqheebiz bmcwwfclsx (uyffijvwci, bwllbigvqj - fvohfeiuog)
-
01 Mar 2012
Phase 3
131
(Sitaxsentan and Placebo)
tnpcmnbjmk(ilpginlsdo) = gsubrizdfh sexwfgmrkb (rmasmzivdh, duinttxflz - chdlvtvzea)
-
29 Feb 2012
(Sitaxsentan and Sildenafil)
tnpcmnbjmk(ilpginlsdo) = edjmfjkibi sexwfgmrkb (rmasmzivdh, ccwmgxaxzg - lmvixuphly)
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Core Patent

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Clinical Trial

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Approval

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Regulation

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