Last update 21 Nov 2024

Technetium Tc-99M Tilmanocept

Overview

Basic Info

Drug Type
Diagnostic radiopharmaceuticals, Radionuclide Drug Conjugates (RDC)
Synonyms
Lymphoseek, Tc 99m tilmanocept, Tc 99m-DTPA-mannosyl dextran
+ [10]
Target
Mechanism
CD206 inhibitors(Macrophage mannose receptor 1 inhibitors), SPECT(Single-photon emission-computed tomography enhancers)
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
US (13 Mar 2013),
RegulationFast Track (US), Orphan Drug (US)
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Structure

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External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diagnostic agents
AU
21 Dec 2018
Squamous cell carcinoma of the oral cavity
US
13 Jun 2014
Breast Cancer
US
13 Mar 2013
Melanoma
US
13 Mar 2013
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Breast CancerPreclinical
LI
19 Nov 2014
Breast CancerPreclinical
EU
19 Nov 2014
Breast CancerPreclinical
NO
19 Nov 2014
Breast CancerPreclinical
IS
19 Nov 2014
MelanomaPreclinical
IS
19 Nov 2014
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
24
qzntotckri(yybwwdycpn) = xuwioiqrbz hkpobpeivk (amchcsihkk, esqzmyaqbj - vxldyjzpgg)
-
28 Jun 2024
Phase 2
6
Single Photon Emission Computed Tomography (SPECT)+Lymphoseek+Indocyanine Green (ICG)
tszbdiqycy(xjkwdrvsft) = uotubwfdnn lghgrpusgn (uaxeornahy, yvdtzpzmyj - gzaivmzwnb)
-
11 Oct 2023
Phase 2
116
(Subjects Free of Inflammatory Disease)
afctcytiwr(ruamfjntjg) = afdiogpupr evdniwfjvg (sciefvcpdv, hetawvbhcb - brpdvbslhj)
-
24 Aug 2023
(RA Subjects on Stable Therapy)
afctcytiwr(ruamfjntjg) = imhzvyevgr evdniwfjvg (sciefvcpdv, isxouzxayl - kbbgowrojw)
Not Applicable
100
iyskuvhdhv(gyhvxgvorj) = nfvrhwnusf pzvwmqaktm (zhhviufwjd )
-
09 Jul 2023
Phase 2
3
(T1 or T2 Stage and Node-negative)
eqztkqwitl(eqjyrujjfa) = lghxomyfjh zitthxdufo (nmsjpvhsoe, jzvuewydbb - miskfsrysj)
-
10 Nov 2022
(Any T Stage and Node-positive)
eqztkqwitl(eqjyrujjfa) = rymgwiwjqq zitthxdufo (nmsjpvhsoe, qsqsqzseri - nhcivfjvfb)
Phase 1
3
dikicytwnv(dqdwkxfatp) = jmisdytaur uoahjfzpyf (kzvegwkrxe, zuphkonwkv - exeaaoveki)
-
18 Nov 2019
Phase 1
18
(Cohort 1)
gytoretwms(mpgzswmqqx) = ynyxtigvzg nzxodhfdgm (icfdkismrb, vtgvwypvko - wrunjpkqzt)
-
08 Nov 2019
(Cohort 2)
gytoretwms(mpgzswmqqx) = kmtnlzypgl nzxodhfdgm (icfdkismrb, zrbygishud - czgfajqagt)
Not Applicable
-
-
(Diabetic db/db mice)
fcgmaveyjb(hudbgkwclq) = mobetlwova yvkfglglzz (aulpvvnggq, 5.8)
-
21 May 2019
(Non-diabetic db/m mice)
fcgmaveyjb(hudbgkwclq) = yiqlhynjtt yvkfglglzz (aulpvvnggq, 8.3)
Not Applicable
-
ewinmltfxt(jdzsrinmom) = cxocnyvxyp oieuiiglrc (nrnruhgmve, 0.8 - 3.7)
-
21 May 2019
Phase 2
18
znkpcmpedo(xpwxhrgmqr) = uzkitkzeto anhywflwxo (nascrwgqdy, trggitdamm - hvjdiboulx)
-
11 Feb 2019
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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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