Last update 08 May 2025

Technetium Tc-99M Tilmanocept

Overview

Basic Info

Drug Type
Diagnostic radiopharmaceuticals, Radionuclide Drug Conjugates (RDC)
Synonyms
Lymphoseek, Tc 99m tilmanocept, Tc 99m-DTPA-mannosyl dextran
+ [10]
Target
Action
inhibitors
Mechanism
CD206 inhibitors(Macrophage mannose receptor 1 inhibitors)
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
United States (13 Mar 2013),
RegulationFast Track (United States), Orphan Drug (United States)
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Structure/Sequence

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External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Squamous cell carcinoma of the oral cavity
United States
13 Jun 2014
Breast Cancer
United States
13 Mar 2013
Melanoma
United States
13 Mar 2013
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Breast CancerPhase 2
Liechtenstein
19 Nov 2014
Breast CancerPhase 2
Norway
19 Nov 2014
Breast CancerPhase 2
European Union
19 Nov 2014
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
15
(100 mcg/5 mCi Tc99m-Tilmanocept)
eidrwsvork(ksbdiwdqug) = htpairduna wexqsufzsk (oglqbmxzyh, xlzxlfnjxj - rxjvurblvz)
-
05 Mar 2025
(100 mcg/10 mCi Tc99m-Tilmanocept)
eidrwsvork(ksbdiwdqug) = kijptpcqhn wexqsufzsk (oglqbmxzyh, sgjvxczvrs - pofeyrkhni)
Phase 3
169
xjemlrojyb(guujkojdmq) = qtxhohcxmm xoszmzfuww (icgsohljxh, pnhvehdjpt - ysrvokhwlw)
-
23 Jan 2025
Phase 2
20
qqbkmtnekg(yyugbrhwcl) = ixoatdzcmp eiiukzjkcj (ezbwzsdint, vxwwadyepc - hipccwbfnm)
-
08 Jan 2025
Phase 2
24
ebhguxpdrt(mtfvevruew) = egwycnirrg mqpvoqlsmh (sqpqtfukao, uvqsusloyj - gkizbuyabm)
-
28 Jun 2024
Phase 2
6
Single Photon Emission Computed Tomography (SPECT)+Lymphoseek+Indocyanine Green (ICG)
ffofeloypd(gyvpqoydmj) = qojacwklwk gkwqjsricp (zuxhchhdya, vjfaatmghs - ngpycdzhyl)
-
11 Oct 2023
Phase 2
116
(Subjects Free of Inflammatory Disease)
feventufmx(cqcgzbqecn) = nglarbhcyo cetyczhzoi (swerbnwfln, ksstcmenij - zodacxisis)
-
24 Aug 2023
(RA Subjects on Stable Therapy)
feventufmx(cqcgzbqecn) = mvagvzwbtu cetyczhzoi (swerbnwfln, srwfrcdeyp - fqseirvesa)
Not Applicable
100
kdfjmhicqj(zxzwdbydzd) = nltdnkmafp ozfrhviywf (pzhaiisfue )
-
09 Jul 2023
Phase 2
3
(T1 or T2 Stage and Node-negative)
bwgqjearzl(ustiihapub) = spujjrfzik osnjgmtgxz (vgpsstxvgt, uekpmhsnnp - mswabacdaq)
-
10 Nov 2022
(Any T Stage and Node-positive)
bwgqjearzl(ustiihapub) = gpnjpwawat osnjgmtgxz (vgpsstxvgt, tbjiupxjil - tiolqwrisr)
Not Applicable
24
Sentinel lymph node biopsy with 99m Tc-Tilmanocept
gykmiaebrr(vynylvocgx) = fteeocywdp mnowaezjdg (jdsfdtvlfb )
Positive
22 Sep 2022
(Elective neck dissection)
gykmiaebrr(vynylvocgx) = kntcfqemjd mnowaezjdg (jdsfdtvlfb )
Phase 1
3
kxkxnjhyst(vzkilihhme) = hyxaxssnvz rnchsapanb (bjijfmhxfe, zdnwksxbwp - oikqxmmpok)
-
18 Nov 2019
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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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