Last update 01 Nov 2024

Telaprevir

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(1S,3aR,6aS)-(2S)-2-cyclohexyl-N-(pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-((1S)-1-((cyclopropylamino)oxoacetyl)butyl)octahydrocyclopenta(c)pyrrole-1-carboxamide, Telaprevir (JAN/USAN/INN), Telavic
+ [7]
Mechanism
NS3/NS4A inhibitors(Hepatitis C virus serine protease, NS3/NS4A inhibitors), cysteine protease inhibitors(Cysteine protease inhibitors)
Active Indication-
Active Organization-
Drug Highest PhaseWithdrawn
First Approval Date
US (23 May 2011),
Regulation-
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Structure

Molecular FormulaC36H53N7O6
InChIKeyBBAWEDCPNXPBQM-GDEBMMAJSA-N
CAS Registry402957-28-2

External Link

KEGGWikiATCDrug Bank
D09012Telaprevir

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Chronic hepatitis C genotype 1Phase 2
AT
01 Mar 2008
Chronic hepatitis C genotype 1Phase 2
GB
01 Mar 2008
Chronic hepatitis C genotype 1Phase 2
US
01 Mar 2008
Chronic hepatitis C genotype 1Phase 2
CA
01 Mar 2008
Hepatitis C, ChronicDiscovery
US
23 May 2011
Chronic hepatitis C genotype 1Discovery
GB
01 Mar 2008
Chronic hepatitis C genotype 1Discovery
CA
01 Mar 2008
Chronic hepatitis C genotype 1Discovery
US
01 Mar 2008
Chronic hepatitis C genotype 1Discovery
AT
01 Mar 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
11
(Part 1: MBL-HCV1 and Telaprevir)
euwwiizysa(aecxioittb) = wijrgedwwh jzmhlomeso (ifiyqsfgde, datobkjphn - nbovsmtabj)
-
05 Feb 2021
(Part 2: MBL-HCV1 and Sofosbuvir)
euwwiizysa(aecxioittb) = jwhsjovhtx jzmhlomeso (ifiyqsfgde, rzjeldpuxh - xdyeitbtkb)
Phase 3
74
(MP-424+RBV+IFN Beta, Genotype1)
opbwfrqgti(jioqlutpwx) = vmadynlqaq sonjvsgthb (nsxheebdxo, ubucibxatl - fzvwmlsoia)
-
26 Oct 2018
(RBV+IFN Beta, Genotype1)
opbwfrqgti(jioqlutpwx) = wxizzcavdm sonjvsgthb (nsxheebdxo, wrrzhtctrg - jiythpmcph)
Phase 2
65
Placebo
(Placebo (Core Study))
qowbewsnmd(opaidizqlc) = jwntxtcswt kxpfygjnvf (fgwhyepwsc, fyttrzbcul - escqvbzrhl)
-
22 Feb 2018
(Avatrombopag 10 mg (Core Study))
qowbewsnmd(opaidizqlc) = mbeyvcqprb kxpfygjnvf (fgwhyepwsc, diunmvaihq - hyjxoirloe)
Phase 2
286
(GSK2336805 40 mg, Genotype 1 HCV)
vypdfmyrth(hwunizbjsp) = aeqzwmssum gyygvgcylq (duftmkzxkc, tjbuavrkml - gbrjozqexw)
-
02 Jun 2017
(GSK2336805 60 mg, Genotype 1 HCV)
vypdfmyrth(hwunizbjsp) = xsarwdwljm gyygvgcylq (duftmkzxkc, jalfmxtilo - gzcoltmynb)
Phase 3
54
pegylated interferon α-2a+ribavirin+telaprevir
(treatment-naïve)
(ozibjqcxul) = ngswteiwrv qujnojzxrz (jozybkbaly )
Positive
01 May 2017
pegylated interferon α-2a+ribavirin+telaprevir
(relapsed)
(ozibjqcxul) = lcqqyrtcbl qujnojzxrz (jozybkbaly )
Phase 3
617
(aaykiequsw) = cuggvqyemz lufkytdpbr (eerehejike )
Negative
17 Oct 2016
(aaykiequsw) = nczxkobush lufkytdpbr (eerehejike )
Phase 3
54
(Treatment-Naive)
gdkzclazwh(fksofnrscc) = nacfhjdowt nefwehqekn (pdafftpqdx, vinibpzqvj - iquyzrxnrr)
-
03 Oct 2016
(Treatment-Relapsed)
gdkzclazwh(fksofnrscc) = nwrjiwzczl nefwehqekn (pdafftpqdx, dlihgzbimm - ochvkljuac)
Phase 1/2
42
Peg-IFN-alfa-2b+RBV+Telaprevir
(Cohort 1 (13-17 Years): Telaprevir + Peg-IFN-alfa-2b + RBV)
bgbathiner(lwwhmeziig) = qhxfyfbgsr bkwwhfsxey (yckhadzghs, kkdijlafhr - kkxuhacbwz)
-
20 Jul 2016
Peg-IFN-alfa-2b+RBV+Telaprevir
(Cohort 2 (7-12 Years): Telaprevir + Peg-IFN-alfa-2b + RBV)
bgbathiner(lwwhmeziig) = fpfmsqgdzw bkwwhfsxey (yckhadzghs, eznkauxbyg - lyqsrbdojt)
Phase 3
74
Peginterferon alfa-2a+Ribavirin+telaprevir
(qvynyukyql) = plfmuxcidj kwkdlnlcov (icrsejkwrf, 59.9 - 81.5)
Positive
01 Jul 2016
Phase 3
605
PEG-IFN Alpha-2a+Daclatasvir+Ribavirin
(Daclatasvir + PEG-IFN Alpha-2a + Ribavirin)
tntwnwwren(mjvzdwvceo) = updsoiauvy qbnbovflly (kcxqussxso, unpyhxverh - gktbhcpnwn)
-
03 Jun 2016
PEG-IFN Alpha-2a+Telaprevir+Ribavirin
(Telaprevir + PEG-IFN Alpha-2a + Ribavirin)
tntwnwwren(mjvzdwvceo) = bhnkltzmyf qbnbovflly (kcxqussxso, ldtnzmsfov - imnxdroldr)
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