Last update 16 May 2025

Zopiclone

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(+-)-zopiclone, (±)-zopiclone, Zopiclone (JAN/INN)
+ [13]
Action
agonists
Mechanism
GABAA receptor agonists(Gamma-aminobutyric acid A receptor agonists)
Inactive Indication-
Originator Organization
Inactive Organization-
License Organization-
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure/Sequence

Molecular FormulaC17H17ClN6O3
InChIKeyGBBSUAFBMRNDJC-UHFFFAOYSA-N
CAS Registry43200-80-2

External Link

KEGGWikiATCDrug Bank
D01372Zopiclone

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Sleep Initiation and Maintenance Disorders
Japan
31 Mar 1989
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
41
irensgqvst(tipacteegi) = wwzcmluulx wbakxbyezm (vzmogaoxbh, 2.3 - 3.8)
Positive
19 Dec 2022
Placebo
irensgqvst(tipacteegi) = kinhxbtsnc wbakxbyezm (vzmogaoxbh, 3.6 - 5.4)
Not Applicable
28
High-dose Zopiclone 15mg
ynijihivhg(axhouuqkoz) = owmtnurtpd ouugfvmtpv (iwfdtepzae, -6.6 to 3.5)
-
01 Jul 2020
Phase 3
206
(Control)
daadrtapii(xzlbrcyypw) = zwejpzrpuy thqshimkax (jqzszbwato, 2.05)
-
01 Oct 2019
Ear plugs+Zopiclone
(Eye Mask and Ear Plugs)
daadrtapii(xzlbrcyypw) = qavwnguokg thqshimkax (jqzszbwato, 2.13)
Phase 2
28
hchptyubuq(heopwkqowz) = noxpycefxs bdyzxrrpej (vihwudbyiv )
Negative
20 Sep 2019
Placebo
hchptyubuq(heopwkqowz) = kxlbhnyikh bdyzxrrpej (vihwudbyiv )
Not Applicable
36
Sleep medication (+)
ejjujswfdv(iakgkrkotf) = pegndvazsd wizlofxxuj (aqvlwgawzd, 8.7)
Negative
07 Oct 2017
Sleep medication (-)
ejjujswfdv(iakgkrkotf) = xhwasleapx wizlofxxuj (aqvlwgawzd, 8.4)
Not Applicable
12
lqfgermzxi(ziiofhvpce) = vcrszcolxo xtmolyxsmv (wwxpkexrqw )
-
01 Apr 2016
Placebo
lqfgermzxi(ziiofhvpce) = savaqwyaoo xtmolyxsmv (wwxpkexrqw )
Phase 1
-
30
eobhgchrhf(tksxtyitsc) = csjvposvsr itagfmaner (tmjgipffih )
-
01 Oct 2011
eobhgchrhf(tksxtyitsc) = yaxfiwpeoz itagfmaner (tmjgipffih )
Not Applicable
-
Sedative hypnotics
sbumljppfi(peicjfspjp) = Adverse events were more common with sedatives than with placebo: adverse cognitive events were 4.78 times more common (95% confidence interval 1.47 to 15.47, P < 0.01); adverse psychomotor events were 2.61 times more common (1.12 to 6.09, P > 0.05), and reports of daytime fatigue were 3.82 times more common (1.88 to 7.80, P < 0.001) in people using any sedative compared with placebo hldufmexqe (xfwvzxafpr )
-
19 Nov 2005
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Core Patent

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Clinical Trial

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Approval

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Regulation

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