Last update 21 Nov 2024

Miransertib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Miransertib (USAN/INN), Miransertib Mesylate
+ [2]
Target
Mechanism
Akt inhibitors(Proto-oncogene proteins c-akt inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (EU)
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Structure

Molecular FormulaC27H24N6
InChIKeyHNFMVVHMKGFCMB-UHFFFAOYSA-N
CAS Registry1313881-70-7

External Link

KEGGWikiATCDrug Bank
D11409--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Proteus SyndromePhase 2
ES
-16 May 2017
Proteus SyndromePhase 2
AU
-16 May 2017
Proteus SyndromePhase 2
US
-16 May 2017
Growth DisordersPhase 2--
PIK3CA-related overgrowth syndromePreclinical
ES
-16 May 2017
PIK3CA-related overgrowth syndromePreclinical
AU
-16 May 2017
PIK3CA-related overgrowth syndromePreclinical
IT
-16 May 2017
PIK3CA-related overgrowth syndromePreclinical
US
-16 May 2017
Proteus SyndromePreclinical
US
-16 May 2017
Proteus SyndromePreclinical
AU
-16 May 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
50
(Part A: Miransertib PROS/PS)
lygtvbmbgx(kxrtmygcug) = clqlznkpyc uqvksnyeit (gtcmuhmfah, oythpjlemw - ekvyemftme)
-
31 Mar 2023
(Part B: Miransertib PROS (Cohort 1))
lygtvbmbgx(kxrtmygcug) = rixxtxmisg uqvksnyeit (gtcmuhmfah, bohdxnzqyu - dbzuomxedg)
Phase 1/2
-
(qshsoirpux) = mostly Grade 1 or 2 AEs exywaiseer (vxbfsfdwpy )
Positive
17 Jun 2019
Not Applicable
6
siufigrwhi(tflqzoywow) = 50% reduction (5/6) myxsveazrr (pxftthlvyt )
Positive
07 Mar 2019
Phase 1
Ovarian Cancer | Endometrial Carcinoma
PIK3CA Mutation | AKT1 Mutation | ER Positive
11
(vitvsfebcl) = 4 pts[rash (n=2), ALT increase (n=1), and hyperglycemia (n=1)] hisfgrypns (euuwcszmok )
Positive
01 Jul 2018
Phase 1
13
(qulofxkdbv) = diarrhea 69%, fatigue 54%, hyperglycemia 31%, maculopapular rash 31%, nausea 23%, mucosal inflammation 23%, anemia 15%, platelet count decreased 15% and hypokalemia 15% kdhxxbyjag (zsbxsedvme )
Positive
05 Jun 2017
Phase 1
22
setaolpljv(ykoanimbkz) = szciwqfziv aezbqylpik (gntiulzmor )
-
15 Apr 2013
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