Drug Type Small molecule drug |
Synonyms Miransertib (USAN/INN), Miransertib Mesylate, ARQ 092 + [2] |
Target |
Action inhibitors |
Mechanism Akt inhibitors(Proto-oncogene proteins c-akt inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Inactive Organization |
License Organization |
Drug Highest PhasePhase 2 |
First Approval Date- |
RegulationOrphan Drug (European Union) |
Molecular FormulaC27H24N6 |
InChIKeyHNFMVVHMKGFCMB-UHFFFAOYSA-N |
CAS Registry1313881-70-7 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Growth Disorders | Phase 2 | Spain | 19 Sep 2019 | |
PIK3CA-related overgrowth syndrome | Phase 2 | Spain | 16 May 2017 | |
Proteus Syndrome | Phase 2 | Spain | 16 May 2017 | |
Endometrial Carcinoma | Phase 1 | United States | 09 Jun 2015 | |
Ovarian Cancer | Phase 1 | United States | 09 Jun 2015 | |
Locally Advanced Malignant Solid Neoplasm | Phase 1 | United States | 01 Nov 2011 | |
Recurrent Lymphoma | Phase 1 | United States | 01 Nov 2011 | |
Heart Defects, Congenital | Preclinical | United States | - | |
Vaso-occlusive crisis | Preclinical | United States | - |
Phase 1/2 | 50 | (Part A: Miransertib PROS/PS) | wusosshtyk = tdmozppfzl scasxjskhf (ozrxyayfpw, qajtwvnqvc - wzamfkpojt) View more | - | 31 Mar 2023 | ||
(Part B: Miransertib PROS (Cohort 1)) | wusosshtyk = urtmaasobq scasxjskhf (ozrxyayfpw, ylegqammvx - rypxhshkti) View more | ||||||
Phase 1/2 | - | rbyvbfzlwv(plgkdsbmlm) = mostly Grade 1 or 2 AEs yxpzgnsuuz (mvgnhyorqh ) View more | Positive | 17 Jun 2019 | |||
Phase 1 | 6 | asmpowdlit(ufwegvqmrw) = 50% reduction (5/6) dkkqcsmfeo (xuesxjdvof ) | Positive | 07 Mar 2019 | |||
Phase 1 | 13 | ryrvcllmbf(prgiseartd) = diarrhea 69%, fatigue 54%, hyperglycemia 31%, maculopapular rash 31%, nausea 23%, mucosal inflammation 23%, anemia 15%, platelet count decreased 15% and hypokalemia 15% pfhwtiavku (zpgdhztozo ) View more | Positive | 05 Jun 2017 | |||
Phase 1 | 22 | vkurwgwkyh(czwxecjosd) = nwymudbqza mewuitqhkn (slgznykksl ) | - | 15 Apr 2013 |