Drug Type Small molecule drug |
Synonyms Miransertib (USAN/INN), Miransertib Mesylate + [2] |
Target |
Mechanism Akt inhibitors(Proto-oncogene proteins c-akt inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhasePhase 2 |
First Approval Date- |
RegulationOrphan Drug (EU) |
Molecular FormulaC27H24N6 |
InChIKeyHNFMVVHMKGFCMB-UHFFFAOYSA-N |
CAS Registry1313881-70-7 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Proteus Syndrome | Phase 2 | ES | - | 16 May 2017 |
Proteus Syndrome | Phase 2 | AU | - | 16 May 2017 |
Proteus Syndrome | Phase 2 | US | - | 16 May 2017 |
Growth Disorders | Phase 2 | - | - | |
PIK3CA-related overgrowth syndrome | Preclinical | ES | - | 16 May 2017 |
PIK3CA-related overgrowth syndrome | Preclinical | AU | - | 16 May 2017 |
PIK3CA-related overgrowth syndrome | Preclinical | IT | - | 16 May 2017 |
PIK3CA-related overgrowth syndrome | Preclinical | US | - | 16 May 2017 |
Proteus Syndrome | Preclinical | US | - | 16 May 2017 |
Proteus Syndrome | Preclinical | AU | - | 16 May 2017 |
Phase 1/2 | 50 | (Part A: Miransertib PROS/PS) | lygtvbmbgx(kxrtmygcug) = clqlznkpyc uqvksnyeit (gtcmuhmfah, oythpjlemw - ekvyemftme) View more | - | 31 Mar 2023 | ||
(Part B: Miransertib PROS (Cohort 1)) | lygtvbmbgx(kxrtmygcug) = rixxtxmisg uqvksnyeit (gtcmuhmfah, bohdxnzqyu - dbzuomxedg) View more | ||||||
Phase 1/2 | - | (qshsoirpux) = mostly Grade 1 or 2 AEs exywaiseer (vxbfsfdwpy ) View more | Positive | 17 Jun 2019 | |||
Not Applicable | 6 | siufigrwhi(tflqzoywow) = 50% reduction (5/6) myxsveazrr (pxftthlvyt ) | Positive | 07 Mar 2019 | |||
NCT02476955 (AACR2018) Manual | Phase 1 | 11 | (vitvsfebcl) = 4 pts[rash (n=2), ALT increase (n=1), and hyperglycemia (n=1)] hisfgrypns (euuwcszmok ) View more | Positive | 01 Jul 2018 | ||
NCT02476955 (ASCO2017) Manual | Phase 1 | 13 | (qulofxkdbv) = diarrhea 69%, fatigue 54%, hyperglycemia 31%, maculopapular rash 31%, nausea 23%, mucosal inflammation 23%, anemia 15%, platelet count decreased 15% and hypokalemia 15% kdhxxbyjag (zsbxsedvme ) View more | Positive | 05 Jun 2017 | ||
Phase 1 | 22 | setaolpljv(ykoanimbkz) = szciwqfziv aezbqylpik (gntiulzmor ) | - | 15 Apr 2013 |