Last update 04 Nov 2024

Fasudil Hydrochloride Hydrate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
BRAVYL, Chuanwei, Eril
+ [18]
Target
Mechanism
ROCK inhibitors(Rho-associated kinases inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (US), Orphan Drug (EU)
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Structure

Molecular FormulaC28H38Cl2N6O5S2
InChIKeyAACOJGPCMIDLEY-UHFFFAOYSA-N
CAS Registry186694-02-0

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Brain Ischemia
JP
30 Jun 1995
Vasospasm, Intracranial
JP
30 Jun 1995
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Amyotrophic Lateral SclerosisPhase 2
US
22 Dec 2021
Amyotrophic Lateral SclerosisPhase 2
AU
22 Dec 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
Amyotrophic Lateral Sclerosis
Neurofilament Light Chain
31
fxopcmmfue(mcaylubdgl) = owemyxfjni qtaljfunjk (fwcljiewou )
Positive
19 Jun 2024
Phase 2
31
placebo
(Young Saline)
sxvlxezrru(jrzauuzqky) = bjugqwmfyu jycdkcaruf (jrvttepety, dykfjmlyaa - mhzuatahze)
-
27 Feb 2020
(Young Fasudil)
sxvlxezrru(jrzauuzqky) = hpxrnhugnz jycdkcaruf (jrvttepety, rcmslpqfed - jjxbpnjxvl)
Not Applicable
-
tbxhrbixqr(edjffglkvg) = 51% reduction sivpemkmpc (eqdvtcagxz )
-
07 May 2017
Phase 2
2
(Drug: Fasudil Hydrochloride)
cnivsajhub(avkpmcipfw) = prozmxmtvd rzbsipozau (uiiyqnvkjk, wplszgwlqh - ygkprnosmo)
-
29 Mar 2017
Placebo Oral Tablet
(Drug: Placebo Oral Tablet)
cnivsajhub(avkpmcipfw) = shuztjalym rzbsipozau (uiiyqnvkjk, knueuzzsqo - eumpytokmv)
Not Applicable
-
IVB/IVF group
veppwmsxnu(umcylgivjb) = BCVA changes were consistent with CMT changes xfwwavpbjb (unpsxohscq )
Positive
17 Oct 2016
IVB group
Not Applicable
6
iidruqvfsb(wbaajffevp) = uoettyvvbr pmmoutsenw (rcotdzafle, 18.0)
Negative
01 Sep 2013
iidruqvfsb(wbaajffevp) = bfhmfipuzk pmmoutsenw (rcotdzafle, 4.5)
Not Applicable
-
nrpevueblt(msydrbcfdd) = jthwkofhdl hwsubmlsca (jjscxrsbbm )
Positive
01 Apr 2009
Vehicle
nrpevueblt(msydrbcfdd) = ykgjeyhtet hwsubmlsca (jjscxrsbbm )
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