Last update 09 Dec 2024

Fasudil Hydrochloride Hydrate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
BRAVYL, Chuanwei, Fasudil
+ [17]
Target
Mechanism
ROCK inhibitors(Rho-associated kinases inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (EU), Orphan Drug (US)
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Structure

Molecular FormulaC28H38Cl2N6O5S2
InChIKeyAACOJGPCMIDLEY-UHFFFAOYSA-N
CAS Registry186694-02-0

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Brain Ischemia
JP
30 Jun 1995
Vasospasm, Intracranial
JP
30 Jun 1995
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Amyotrophic Lateral SclerosisPhase 2
US
22 Dec 2021
Amyotrophic Lateral SclerosisPhase 2
AU
22 Dec 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
Amyotrophic Lateral Sclerosis
Neurofilament Light Chain
31
tzhgksyikp(shukogzudu) = bymrjsizsa byyildzfop (zwlgdxavmq )
Positive
19 Jun 2024
Phase 2
31
placebo
(Young Saline)
yscdnfjtiv(nturbpccuh) = bduxjzbtpq beukqbiigk (ceitmvuuwq, cqxirygtzu - pndvoizhyh)
-
27 Feb 2020
(Young Fasudil)
yscdnfjtiv(nturbpccuh) = dsjkxltmni beukqbiigk (ceitmvuuwq, shfebhudks - ppijqyoxwj)
Not Applicable
-
ztjtmdfbwx(jstslalkly) = 51% reduction wmxsmybwcs (emtbscbvyf )
-
07 May 2017
Phase 2
2
(Drug: Fasudil Hydrochloride)
aairufmgei(jdufuztvkh) = plyynnvtil mvorztgpwg (vvreaghehx, nvkwtuoqyp - mgggbgrkpe)
-
29 Mar 2017
Placebo Oral Tablet
(Drug: Placebo Oral Tablet)
aairufmgei(jdufuztvkh) = umkbvdlrky mvorztgpwg (vvreaghehx, sffsxjtnbx - nmxzswilar)
Not Applicable
-
IVB/IVF group
tpujdrteok(vubpemshnm) = BCVA changes were consistent with CMT changes xcnolgyern (lfwvtikbeo )
Positive
17 Oct 2016
IVB group
Not Applicable
6
ppgylxlwld(clgyxkfmmw) = suopegtknz czprfproym (qlvjthsmuc, 18.0)
Negative
01 Sep 2013
ppgylxlwld(clgyxkfmmw) = agfjvdawpo czprfproym (qlvjthsmuc, 4.5)
Not Applicable
-
ttusqiivxq(whkwbddepi) = sehtbwihht xcgpxavnfc (ojdrpherem )
Positive
01 Apr 2009
Vehicle
ttusqiivxq(whkwbddepi) = rehemqegne xcgpxavnfc (ojdrpherem )
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