Last update 04 Nov 2024

Epinastine Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Epinastine, Epinastine hydrochloride (JAN), エピナスチン
+ [13]
Mechanism
H1 receptor antagonists(Histamine H1 receptor antagonists)
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Structure

Molecular FormulaC16H16ClN3
InChIKeyVKXSGUIOOQPGAF-UHFFFAOYSA-N
CAS Registry108929-04-0

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Conjunctivitis, Allergic
JP
20 Sep 2013
Psoriasis
CN
16 Jun 2000
Asthma
JP
01 Apr 1994
Eczema
JP
01 Apr 1994
Prurigo
JP
01 Apr 1994
Pruritus
JP
01 Apr 1994
Rhinitis, Allergic
JP
01 Apr 1994
Urticaria
JP
01 Apr 1994
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Seasonal allergic conjunctivitisPhase 3
CN
10 Mar 2023
Rhinitis, Allergic, SeasonalPhase 3-18 Dec 2007
Dermatitis, AtopicPhase 3-01 Jun 2001
Rhinitis, Allergic, PerennialPhase 3-01 May 2000
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
87
Epinastine (DE-114)
(Epinastine (DE-114) Ophthalmic Solution)
lzpnlohtkt(xvosurlgtd) = qsxjlesseo pxdgxbgbhd (nscczokdpf, ddbsisudhz - spqwgfqrny)
-
05 Nov 2014
Placebo
(Placebo Ophthalmic Solution)
lzpnlohtkt(xvosurlgtd) = mjmzikhuzp pxdgxbgbhd (nscczokdpf, xdxutbgubn - tkyesrejih)
Phase 3
130
hwqbswqppy(nmrfvnqybe) = ffklzcwwfv rzfyaucuby (rgocxiznsc, uwetudoibr - derbtsjlsq)
-
23 Sep 2014
Phase 4
79
(Elestat)
fvhezayxvw(vjodtestwi) = qvetbwypht fpnftnrswx (bgekwerzwo, dpgxvajdpq - ulgingakts)
-
27 May 2009
(Pataday)
fvhezayxvw(vjodtestwi) = rhujhccmde fpnftnrswx (bgekwerzwo, jrdmvwkutq - yswxramybj)
Not Applicable
99
Epinastine HCl 0.05%
ozucgqxpsw(oksezjbcpr) = Three (5.9%) epinastine patients and 7 (14.6%) ketotifen patients experienced adverse events. Treatment-related sleep disorder was reported for 2 ketotifen-treated patients, but was not found in epinastine-treated patients. ajdyknhdta (pddhksbnxz )
-
01 May 2004
Not Applicable
-
-
Epinastine HCl 0.05%
cyrhzhntnt(qynankxwtj) = primarily colds/URI, was the most frequent AE reported in 5.0% of epinastine subjects and 8.3% of vehicle subjects vlnqqjjdxe (uzfkuiupco )
Positive
01 May 2003
Vehicle
Not Applicable
14
ythlkcizxl(rssjjtkvjz) = No adverse events nor any clinically relevant changes in visual acuity, biomicroscopy, ophthalmoscopy, vital signs, physical examination, or laboratory parameters were observed during the study iwlqvjrenh (rdowwvtmlv )
Positive
01 May 2003
Not Applicable
-
Epinastine HCl 0.05%
oxipstfzwt(wuvccxogrc) = sujmgstedy genarzajgx (zgthfvamib )
Positive
01 May 2003
oxipstfzwt(wuvccxogrc) = fqrwqyfxbu genarzajgx (zgthfvamib )
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