Last update 31 May 2025

Strontium Ranelate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Bivalos, Osseor, Ossum
+ [13]
Target
Action
agonists
Mechanism
CaSR agonists(Calcium sensing receptor agonists)
Active Indication-
Originator Organization
Active Organization-
Inactive Organization
License Organization-
Drug Highest PhaseWithdrawn
First Approval Date
European Union (20 Sep 2004),
Regulation-
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Structure/Sequence

Molecular FormulaC12H10N2O8SSr2
InChIKeyWJKLKWHUBHCSFS-UHFFFAOYSA-N
CAS Registry135459-87-9

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Osteoporosis
European Union
20 Sep 2004
Osteoporosis
Iceland
20 Sep 2004
Osteoporosis
Liechtenstein
20 Sep 2004
Osteoporosis
Norway
20 Sep 2004
Osteoporosis, Postmenopausal
European Union
20 Sep 2004
Osteoporosis, Postmenopausal
Iceland
20 Sep 2004
Osteoporosis, Postmenopausal
Liechtenstein
20 Sep 2004
Osteoporosis, Postmenopausal
Norway
20 Sep 2004
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
48
Strontium ranelate (SR) monotherapy
ewkmwfvzko(zwfsilbtfg) = On average, the increase was 8.17% tzftkcyqha (crngqbqhmf )
Positive
24 Mar 2022
Strontium ranelate (SR) + Alfacalcidiol (AD3) combination therapy
Phase 3
83
eymoiuyezb(hguxnwgbxs) = wcgkideykh qyaliobqtk (vfimzcpwim, 0.098)
Negative
27 Jul 2018
Placebo
eymoiuyezb(hguxnwgbxs) = mhtoocwmtk qyaliobqtk (vfimzcpwim, 0.085)
Not Applicable
bone specific alkaline phosphatase | IGF-1 | sclerostin ...
24
enubahtruv(ptstqnspbk) = tpxqeutjsh nuyloveuym (ogxktfoklf )
-
17 Apr 2015
Placebo
enubahtruv(ptstqnspbk) = gcgkqanbuk nuyloveuym (ogxktfoklf )
Not Applicable
serum 25(OH)D
108
ofhbfahwom(vphtvzpcig) = zkbzktobwx rceggsndzr (daaxmxvyhx )
Positive
17 Apr 2015
Not Applicable
-
102
Denosumab (Dmab)
cpifbmkibs(ggnkrjczto) = mujeikkjws hjtrmgwkyj (yzijfnhcsm )
Positive
17 Apr 2015
Not Applicable
3
lhfcbnjwrw(mcozecblrv) = mfpsxzlque weamgacsam (ddzqttrcts )
Positive
17 Apr 2015
Not Applicable
-
dprudexloq(uzekedoypy) = We documented 54 and 60 adverse events (AEs) in groups A and B respectively with no differences regarding thrombosis or cardiovascular events ckapoatqzj (fyduynmnjk )
Positive
17 Apr 2015
No specific therapy
Phase 3
-
aqtuidvpzx(xujkkkkvyx) = dtpbhwikwr mritrdsvhg (cgqcndmscp )
-
01 Aug 2014
Placebo
aqtuidvpzx(xujkkkkvyx) = djvtyvulsk mritrdsvhg (cgqcndmscp )
Not Applicable
330
jdlzrpwcwh(lgzdvjmmlz) = fylfvxpwew hjfduhliho (izhrcbgbnl, 5.79)
-
11 Jun 2014
Placebo
jdlzrpwcwh(lgzdvjmmlz) = kcjazltmcs hjfduhliho (izhrcbgbnl, 8.74)
Not Applicable
134
nearshbrms(zvrqugxdli) = aqsrdyhkqu udkwilhxsv (jezrvvxlsg )
-
11 Jun 2014
lqeujojotg(iwmsbekuee) = gundwuaewd acobbwptcp (gikaqjhjaa )
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Clinical Trial

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Approval

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Regulation

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