Delving into the Latest Updates on Moxonidine with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Moxodin, Moxonidine (USAN/INN), Moxonidine Hydrochloride

+ [16]

Target

ADRA2

Action

agonists

Mechanism

ADRA2 agonists(Adrenergic receptors alpha-2 agonists)

Therapeutic Areas

Cardiovascular Diseases

Active Indication

Hypertension

Inactive Indication-

Originator Organization-

Active Organization

Viatris Pty Ltd.

Inactive Organization-

License Organization-

Drug Highest PhaseApproved

First Approval Date

Germany (01 Jan 1991),

Hypertension

Regulation-

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Structure/Sequence

Molecular FormulaC9H12ClN5O

InChIKeyWPNJAUFVNXKLIM-UHFFFAOYSA-N

CAS Registry75438-57-2

We will study obese hypertensive subjects in a randomized, crossover study to determine if two weeks sympathetic blockade improves endogenous glucose production. Subjects will be studied on 3 different occasions after two weeks of receiving either placebo, amlodipine (vasodilator arm) or moxonidine (study arm). The order of the studies will be determined using computer-generated randomization. Patients will be blinded as to which treatment they are receiving on each day. An investigator blinded to the treatment assignment will perform the analysis of the data.

Start Date20 May 2022

Sponsor / Collaborator

Vanderbilt University Medical Center

CTRI/2021/11/038087

/ Not yet recruitingNot ApplicableIIT

COMPARISON OF ORAL CLONIDINE AND MOXONIDINE ON SENSORY AND MOTOR CHARACTERISTICS OF SUBARACHNOID BLOCK

Start Date11 Dec 2021

Sponsor / Collaborator-

NCT04140721

/ Active, not recruitingEarly Phase 1IIT

Autonomic Determinants of Postural Tachycardia Syndrome (Chronic Pilot Study 2)

Postural tachycardia syndrome (POTS) is a relatively common condition affecting mostly otherwise healthy young women. These patients have high heart rate and disabling symptoms during standing. Quality of life may be poor. The sympathetic nerves in the autonomic nervous system help to maintain normal blood pressures and heart rates during activities of daily life.
The purpose of this study is to determine the importance of sympathetic activation as a cause of orthostatic symptoms. The investigators will assess the effects of a blood pressure medication (Moxonidine) on the symptoms during standing. Moxonidine lowers sympathetic activity. The investigators believe patients with high resting sympathetic activity might benefit from Moxonidine. It might reduce high heart rate and improve symptoms during standing. This study should help clinicians and the growing population of patients with POTS gain a better understanding of this disorder and find more personalized treatment.

Start Date31 Aug 2021

Sponsor / Collaborator

Vanderbilt University Medical Center

[+1]

100 Clinical Results associated with Moxonidine

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100 Translational Medicine associated with Moxonidine

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100 Patents (Medical) associated with Moxonidine

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916

Literatures (Medical) associated with Moxonidine

01 Apr 2025·International Journal of Biological Macromolecules

Effects of rumen-degradable starch on lactation performance, gastrointestinal fermentation, and plasma metabolomic in dairy cows

Article

Author: Li, Shengli ; Wang, Wei ; Dai, Dongwen ; Wang, Shuxiang ; Shen, Yanjun ; Li, Chen ; Dong, Chunxiao ; Kong, Fangling ; Chai, Shatuo ; Wang, Shuo

This study investigated the effects of rumen-degradable starch (RDS) on lactation performance, gastrointestinal fermentation, and plasma metabolomics in dairy cows. Six mid-lactation cows, fitted with rumen, duodenum, and ileum cannulas, were used in a duplicated 3 × 3 Latin square design with 28-day periods. The cows were fed a low RDS (LRDS; 62.18 %), medium-RDS (MRDS; 71.25 %), or high-RDS (HRDS; 80.32 %) diet. The results showed that cows fed HRDS had diet a lower milk fat content by 14.77 % (LRDS) and 11.73 % (MRDS), while increased somatic cell count compared to the LRDS and MRDS groups (34.42 and 29.38 %, respectively). Additionally, rumen fluid pH was decreased in the HRDS group than in the MRDS and LRDS groups (7.81 and 7.08 %, respectively), while microbial protein (MCP) concentration was higher in the MRDS group. The HRDS group had lower concentrations of total volatile fatty acids (TVFA) and acetate in the ileal digesta than the LRDS group. The HRDS diet decreased neutral detergent fibre (NDF) digestibility compared with LRDS and MRDS groups (7.68 and 8.50 %, respectively), and reduced plasma concentrations of superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX), while increasing plasma lipopolysaccharide (LPS) and serum amyloid-A (SAA) levels. Pathway analysis revealed that starch and sucrose metabolism, galactose metabolism, and carbohydrate digestion and absorption were upregulated in the MRDS and HRDS groups. The HRDS diet had a tendency to negatively affect linoleic acid metabolism, glycerophospholipid metabolism, and alpha-linolenic acid metabolism. These findings provide insights into optimising feed efficiency and milk quality by regulating RDS levels in dairy cow diets.

01 Jan 2025·Neuroscience Letters

Agmatine diminishes behavioral and endocrine alterations in a rat model of post-traumatic stress disorder

Article

Author: Aglawe, Manish M ; Kale, Mayur B ; Upaganlawar, Aman B ; Kopalli, Spandana Rajendra ; Taksande, Brijesh G ; Banarase, Trupti A ; Umekar, Milind J ; Siddiqui, Mohd Shahnavaj ; Wankhede, Nitu L ; Koppula, Sushruta ; Rahangdale, Sandip R

Post-traumatic stress disorder (PTSD), is a severe anxiety disorder characterized by associative fear conditioning. Single prolonged stress (SPS) is a widely accepted reliable animal model to stimulate PTSD. Agmatine is an endogenous neuromodulator of stress; however, its effect on PTSD remains to be investigated. This study explored the role of agmatine in conditioned fear response (CFR) in PTSD and highlighted the role of imidazoline receptors in the effect of agmatine. Intra-cerebroventricular (icv) surgery was done in order to facilitate drug administration. Animals were subjected to SPS. Agmatine and the involvement of imidazoline receptors (I₁ and I₂) were assessed for their effect in fear conditioning apparatus. During weeks 1, 2, and 3, in CFR, agmatine (40 µg/rat, icv) showed significantly decreased freezing time whereas other doses of agmatine (10 and 20 µg/rat, icv). Imidazoline (I₁ and I₂) receptor agonists Moxonidine (25 µg/rat, icv) and 2-BFI, (10 µg/rat, icv) respectively, at their sub-effective doses, with a submaximal dose of agmatine (20 µg/rat, icv) significantly decreased the altered freezing time during weeks 1, 2 and 3 compared to SPS animals. Moreover, the effective dose of agmatine (40 µg/rat, icv) with imidazoline (I₁ and I₂) receptor antagonists Efaroxan (10 µg/rat, icv) and Idazoxan (4 µg/rat, icv) respectively does not reversed the effect of agmatine on freezing. Agmatine and its combination with I₁ and I₂ agonists, normalized the altered freezing behavior, corticosterone level, organ coefficient of adrenal gland, neuroinflammatory and neurotrophic factor due to SPS during CFR projecting its strong therapeutic effect in SPS induced PTSD.

01 Dec 2024·Bioorganic Chemistry

Spatial metabolomics to discover hypertrophic scar relevant metabolic alterations and potential therapeutic strategies: A preliminary study

Article

Author: Zhang, Enyuan ; Zeng, Siqi ; Jiang, Jingbin ; Li, Jun ; Li, Jingyun ; Chen, Ling

Spatially mapping the metabolic remodeling of hypertrophic scar and surrounding normal skin tissues has the potential to enhance our comprehension of scar formation and aid in the advancement of therapeutic interventions. In this study, we employed matrix-assisted laser desorption/ionization (MALDI), a mass spectrometry imaging technique, to visualize the hierarchical distribution of metabolites within sections of hypertrophic scar and surrounding normal skin tissues. A comprehensive analysis identified a total of 1631 metabolites in these tissues. The top four classes that were identified included benzene and substituted derivatives, heterocyclic compounds, amino acids and its metabolites, and glycerophospholipids. In hypertrophic scar tissues, 22 metabolites were upregulated and 66 metabolites were downregulated. MetaboAnalyst pathway analysis indicated that glycerophospholipid metabolism was primarily associated with these altered 88 metabolites. Subsequently, six metabolites were selected, their spatial characteristics were analyzed, and they were individually added to the cell culture medium of primary hypertrophic scar fibroblasts. The preliminary findings of this study demonstrate that specific concentrations of 1-pyrrolidinecarboxamide, 2-benzylideneheptanal, glycerol trioleate, Lyso-PAF C-16, and moxonidine effectively inhibited the expressions of COL1A1, COL1A2, COL3A1, and ACTA2. These bioactive metabolites exhibit mild and non-toxic properties, along with favorable pharmacokinetics and pharmacodynamics, making them promising candidates for drug development. Consequently, this research offers novel therapeutic insights for hypertrophic scar treatment.

100 Deals associated with Moxonidine

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External Link

KEGG	Wiki	ATC	Drug Bank
D05087	Moxonidine	C02AC05	DB09242

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Hypertension	Germany	-	01 Jan 1991

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT02355821 (COMPASS, CTgov)	Not Applicable	Bone Diseases, Metabolic \| Hypertension	114	Moxonidine (Moxonidine)	qecvopfvpi(mjppjdxtjk) = wxvcurpovm gjlcvaedcy (zekqisrxsn, jyrpmeafuw - jipdzfzssh) View more	-	01 Sep 2021
				Bisoprolol (Bisoprolol)	qecvopfvpi(mjppjdxtjk) = tlljbzaimi gjlcvaedcy (zekqisrxsn, clgqdgqmxl - ynntpalcmp) View more
ESH2021	Not Applicable	-	-	Moxonidine	(cnogqkporc) = nefyjqxbaq hyedeazngv (lcldkprvvf ) View more	Positive	01 Apr 2021
				Bisoprolol	(cnogqkporc) = gqccmzzvll hyedeazngv (lcldkprvvf ) View more
ESC2018	Not Applicable	-	-	Moxonidine	(luueewwsdp) = fezsusezey ksalenpyyv (graqpknjuo ) View more	-	27 Aug 2018
				Bisoprolol	(luueewwsdp) = ooqlhaqrjz ksalenpyyv (graqpknjuo ) View more
NCT01504321 (Pubmed \| Front Physiol)	Phase 4	Polycystic Ovary Syndrome	48	Moxonidine	gereowwazk(yfpqtmpzth) = mlxqxzxapk dqxquvzjbe (toopbxcjia ) View more	-	01 Jan 2018
				Placebo	gereowwazk(yfpqtmpzth) = ovrwviavyk dqxquvzjbe (toopbxcjia ) View more
PP.18.22 (ESH2017)	Not Applicable	Overweight	-	Low Calorie Diet + Moxonidine 0.4 mg/day	bdasfiryny(czixmdcoiy) = qjflyetvrp mjtskkiwqg (egyrzjinic )	Positive	01 Sep 2017
SFN2012	Not Applicable	-	-	Moxonidine	jhwontjzpk(uqwyusexqy) = rbzlakocan yviyahlsoc (amtgacfuef ) View more	-	14 Oct 2012
				Vehicle	jhwontjzpk(uqwyusexqy) = rmwjvnpbpy yviyahlsoc (amtgacfuef ) View more
SFN2012	Not Applicable	Hypernatremia	-	Moxonidine	huqixaotit(padctpacvv) = hdonzqutim gejqobszrv (xsfngkgnbi, 5.5) View more	-	14 Oct 2012
				Saline	huqixaotit(padctpacvv) = ljcdjqfbqu gejqobszrv (xsfngkgnbi, 0.5) View more
569 (ESH2012)	Not Applicable	Metabolic Syndrome	27	Moxonidine 0.4 mg daily	yzsikhtfok(xuhorlqrbb) = mcefhesqtd cweyenzpps (qxlkgwntuc ) View more	Positive	01 Sep 2012
				Amlodipine 5 mg daily	yzsikhtfok(xuhorlqrbb) = bciyrwywhx cweyenzpps (qxlkgwntuc ) View more
SFN2011	Not Applicable	-	-	Carbachol	izioqlaarv(ujunxquuho) = bqlfwgsjur zvivvpyzsd (zfynesyueb ) View more	-	15 Nov 2011
				Moxonidine	izioqlaarv(ujunxquuho) = dvioivyion zvivvpyzsd (zfynesyueb ) View more
SFN2010	Not Applicable	Urinary Bladder, Neurogenic	-	moxonidine (Sham surgery)	yxswpyahyc(hczflfcjkr) = vqxkdohukb enptiovrff (vvdtagekjn )	-	17 Nov 2010
				moxonidine (Parasympathetic denervation)	yxswpyahyc(hczflfcjkr) = vdfmaxsosu enptiovrff (vvdtagekjn )