Delving into the Latest Updates on Moxonidine with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Moxodin, Moxonidine (USAN/INN), Moxonidine Hydrochloride

+ [16]

Target

ADRA2

Action

agonists

Mechanism

ADRA2 agonists(Adrenergic receptors alpha-2 agonists)

Therapeutic Areas

Cardiovascular Diseases

Active Indication

Hypertension

Inactive Indication-

Originator Organization-

Active Organization

Viatris Pty Ltd.

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date

Germany (01 Jan 1991),

Hypertension

Regulation-

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Structure/Sequence

Molecular FormulaC9H12ClN5O

InChIKeyWPNJAUFVNXKLIM-UHFFFAOYSA-N

CAS Registry75438-57-2

We will study obese hypertensive subjects in a randomized, crossover study to determine if two weeks sympathetic blockade improves endogenous glucose production. Subjects will be studied on 3 different occasions after two weeks of receiving either placebo, amlodipine (vasodilator arm) or moxonidine (study arm). The order of the studies will be determined using computer-generated randomization. Patients will be blinded as to which treatment they are receiving on each day. An investigator blinded to the treatment assignment will perform the analysis of the data.

Start Date20 May 2022

Sponsor / Collaborator

Vanderbilt University Medical Center

CTRI/2021/11/038087

/ Not yet recruitingNot ApplicableIIT

COMPARISON OF ORAL CLONIDINE AND MOXONIDINE ON SENSORY AND MOTOR CHARACTERISTICS OF SUBARACHNOID BLOCK

Start Date11 Dec 2021

Sponsor / Collaborator-

NCT04140721

/ Active, not recruitingEarly Phase 1IIT

Autonomic Determinants of Postural Tachycardia Syndrome (Chronic Pilot Study 2)

Postural tachycardia syndrome (POTS) is a relatively common condition affecting mostly otherwise healthy young women. These patients have high heart rate and disabling symptoms during standing. Quality of life may be poor. The sympathetic nerves in the autonomic nervous system help to maintain normal blood pressures and heart rates during activities of daily life.
The purpose of this study is to determine the importance of sympathetic activation as a cause of orthostatic symptoms. The investigators will assess the effects of a blood pressure medication (Moxonidine) on the symptoms during standing. Moxonidine lowers sympathetic activity. The investigators believe patients with high resting sympathetic activity might benefit from Moxonidine. It might reduce high heart rate and improve symptoms during standing. This study should help clinicians and the growing population of patients with POTS gain a better understanding of this disorder and find more personalized treatment.

Start Date31 Aug 2021

Sponsor / Collaborator

Vanderbilt University Medical Center

[+1]

100 Clinical Results associated with Moxonidine

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100 Translational Medicine associated with Moxonidine

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100 Patents (Medical) associated with Moxonidine

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918

Literatures (Medical) associated with Moxonidine

01 Jan 2025·Neuroscience Letters

Agmatine diminishes behavioral and endocrine alterations in a rat model of post-traumatic stress disorder

Article

Author: Aglawe, Manish M ; Kale, Mayur B ; Upaganlawar, Aman B ; Kopalli, Spandana Rajendra ; Taksande, Brijesh G ; Banarase, Trupti A ; Umekar, Milind J ; Koppula, Sushruta ; Siddiqui, Mohd Shahnavaj ; Rahangdale, Sandip R ; Wankhede, Nitu L

Post-traumatic stress disorder (PTSD), is a severe anxiety disorder characterized by associative fear conditioning. Single prolonged stress (SPS) is a widely accepted reliable animal model to stimulate PTSD. Agmatine is an endogenous neuromodulator of stress; however, its effect on PTSD remains to be investigated. This study explored the role of agmatine in conditioned fear response (CFR) in PTSD and highlighted the role of imidazoline receptors in the effect of agmatine. Intra-cerebroventricular (icv) surgery was done in order to facilitate drug administration. Animals were subjected to SPS. Agmatine and the involvement of imidazoline receptors (I₁ and I₂) were assessed for their effect in fear conditioning apparatus. During weeks 1, 2, and 3, in CFR, agmatine (40 µg/rat, icv) showed significantly decreased freezing time whereas other doses of agmatine (10 and 20 µg/rat, icv). Imidazoline (I₁ and I₂) receptor agonists Moxonidine (25 µg/rat, icv) and 2-BFI, (10 µg/rat, icv) respectively, at their sub-effective doses, with a submaximal dose of agmatine (20 µg/rat, icv) significantly decreased the altered freezing time during weeks 1, 2 and 3 compared to SPS animals. Moreover, the effective dose of agmatine (40 µg/rat, icv) with imidazoline (I₁ and I₂) receptor antagonists Efaroxan (10 µg/rat, icv) and Idazoxan (4 µg/rat, icv) respectively does not reversed the effect of agmatine on freezing. Agmatine and its combination with I₁ and I₂ agonists, normalized the altered freezing behavior, corticosterone level, organ coefficient of adrenal gland, neuroinflammatory and neurotrophic factor due to SPS during CFR projecting its strong therapeutic effect in SPS induced PTSD.

01 Dec 2024·Journal of Hypertension

Targeting the sympathetic nervous system with the selective imidazoline receptor agonist moxonidine for the management of hypertension: an international position statement

Review

Author: Schlaich, Markus P. ; Borghi, Claudio ; Taddei, Stefano ; Marketou, Maria ; Kiuchi, Marcio G. ; Sindone, Andrew ; Farcas, Anca ; Tsioufis, Konstantinos ; Ferri, Claudio ; Cooper, Mark ; Vintila, Ana Maria ; Chandrappa, Shukrath ; Parissis, John

Hypertension is often linked with metabolic risk factors that share common pathophysiological pathways. Despite wide-spread availability of multiple drug classes, optimal blood pressure (BP) control remains challenging. Increased central sympathetic outflow is frequently neglected as a critical regulator of both circulatory and metabolic pathways and often remains unopposed therapeutically. Selective imidazoline receptor agonists (SIRAs) effectively reduce BP with a favorable side effect profile compared with older centrally acting antihypertensive drugs. Hard outcome data in hypertension, such as prevention of stroke, heart and kidney diseases, are not available with SIRAs. However, in direct comparisons, SIRAs were as effective as angiotensin-converting enzyme inhibitors, β-blockers, calcium channel blockers, and diuretics in lowering BP. Other beneficial effects on metabolic parameters in hypertensive patients with concomitant overweight and obesity have been documented with SIRAs. Here we review the existing evidence on the safety and efficacy of moxonidine, a widely available SIRA, compared with common antihypertensive agents and provide a consensus position statement based on inputs from 12 experts from Europe and Australia on SIRAs in hypertension management.

01 Dec 2024·Bioorganic Chemistry

Spatial metabolomics to discover hypertrophic scar relevant metabolic alterations and potential therapeutic strategies: A preliminary study

Article

Author: Jiang, Jingbin ; Zeng, Siqi ; Zhang, Enyuan ; Li, Jun ; Li, Jingyun ; Chen, Ling

Spatially mapping the metabolic remodeling of hypertrophic scar and surrounding normal skin tissues has the potential to enhance our comprehension of scar formation and aid in the advancement of therapeutic interventions. In this study, we employed matrix-assisted laser desorption/ionization (MALDI), a mass spectrometry imaging technique, to visualize the hierarchical distribution of metabolites within sections of hypertrophic scar and surrounding normal skin tissues. A comprehensive analysis identified a total of 1631 metabolites in these tissues. The top four classes that were identified included benzene and substituted derivatives, heterocyclic compounds, amino acids and its metabolites, and glycerophospholipids. In hypertrophic scar tissues, 22 metabolites were upregulated and 66 metabolites were downregulated. MetaboAnalyst pathway analysis indicated that glycerophospholipid metabolism was primarily associated with these altered 88 metabolites. Subsequently, six metabolites were selected, their spatial characteristics were analyzed, and they were individually added to the cell culture medium of primary hypertrophic scar fibroblasts. The preliminary findings of this study demonstrate that specific concentrations of 1-pyrrolidinecarboxamide, 2-benzylideneheptanal, glycerol trioleate, Lyso-PAF C-16, and moxonidine effectively inhibited the expressions of COL1A1, COL1A2, COL3A1, and ACTA2. These bioactive metabolites exhibit mild and non-toxic properties, along with favorable pharmacokinetics and pharmacodynamics, making them promising candidates for drug development. Consequently, this research offers novel therapeutic insights for hypertrophic scar treatment.

100 Deals associated with Moxonidine

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External Link

KEGG	Wiki	ATC	Drug Bank
D05087	Moxonidine	C02AC05	DB09242

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Hypertension	Germany	-	01 Jan 1991

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT02355821 (COMPASS, CTgov)	Not Applicable	Bone Diseases, Metabolic \| Hypertension	114	Moxonidine (Moxonidine)	robxykljtq(iecdakggyj) = ioxisvruyn jhxlnrwkoi (zthtmfvocb, otnfemwkfs - ckrfgosxyu) View more	-	01 Sep 2021
				Bisoprolol (Bisoprolol)	robxykljtq(iecdakggyj) = bqiahnqmpz jhxlnrwkoi (zthtmfvocb, hpizzjfmyi - vhhuvzkmle) View more
ESH2021	Not Applicable	-	-	Moxonidine	(vagpongpib) = aduencdhzv fpmdxgwtjh (thsnianrzn ) View more	Positive	01 Apr 2021
				Bisoprolol	(vagpongpib) = qlbjilevab fpmdxgwtjh (thsnianrzn ) View more
ESC2018	Not Applicable	-	-	Moxonidine	(kptbjhmkrk) = vegibrffiw wnlgqpflgk (msxxcpdrbk ) View more	-	27 Aug 2018
				Bisoprolol	(kptbjhmkrk) = dgynlpmqrd wnlgqpflgk (msxxcpdrbk ) View more
NCT01504321 (Pubmed \| Front Physiol)	Phase 4	Polycystic Ovary Syndrome	48	Moxonidine	ulwefngyfa(oqzhqesnbl) = lsdafkeajn gxwofhcuqw (skzowhlzmr ) View more	-	01 Jan 2018
				Placebo	ulwefngyfa(oqzhqesnbl) = ojusmkzafj gxwofhcuqw (skzowhlzmr ) View more
PP.18.22 (ESH2017)	Not Applicable	Overweight	-	Low Calorie Diet + Moxonidine 0.4 mg/day	lzdqezixsd(fevzbcjrhy) = svopgjrdct qlqkuhfzwb (tjqytlxsrk )	Positive	01 Sep 2017
SFN2012	Not Applicable	-	-	Moxonidine	sjgtvfxrmu(qkoeqkfcaj) = ceiuurcjkf yfclsygxkr (isvajrepzj ) View more	-	14 Oct 2012
				Vehicle	sjgtvfxrmu(qkoeqkfcaj) = wotoowcrdr yfclsygxkr (isvajrepzj ) View more
SFN2012	Not Applicable	Hypernatremia	-	Moxonidine	roumwlivcx(zqarzmbhnt) = xzexrpprqc hsxuglwbya (sxlibslbmy, 5.5) View more	-	14 Oct 2012
				Saline	roumwlivcx(zqarzmbhnt) = jiulxobynm hsxuglwbya (sxlibslbmy, 0.5) View more
569 (ESH2012)	Not Applicable	Metabolic Syndrome	27	Moxonidine 0.4 mg daily	wtrpmegpup(pgqvriwdqx) = divjjbmybz iztchjujen (skksmigcyv ) View more	Positive	01 Sep 2012
				Amlodipine 5 mg daily	wtrpmegpup(pgqvriwdqx) = iffczbxdtg iztchjujen (skksmigcyv ) View more
SFN2011	Not Applicable	-	-	Carbachol	gyoyhaygui(xmewqzbuma) = jeuibzmqbu izzyrsdewu (gpxibsnzkg ) View more	-	15 Nov 2011
				Moxonidine	gyoyhaygui(xmewqzbuma) = dnyaysozuz izzyrsdewu (gpxibsnzkg ) View more
SFN2010	Not Applicable	Urinary Bladder, Neurogenic	-	moxonidine (Sham surgery)	slcfcxroki(eenztwxtal) = sxqhblyigv lglnjdjnvz (kwkkrtfadq )	-	17 Nov 2010
				moxonidine (Parasympathetic denervation)	slcfcxroki(eenztwxtal) = mthnjygdyg lglnjdjnvz (kwkkrtfadq )