Last update 01 Nov 2024

Tirapazamine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
1,2,4-benzotriazin-3-amine, 1,4-dioxide, 3-Amino-1,2,4-benzotriazine 1,4-dioxide, Tirapazamine (USAN/INN)
+ [12]
Target
Mechanism
Top II inhibitors(Topoisomerase II inhibitors)
Originator Organization
Drug Highest PhasePhase 3
First Approval Date-
RegulationOrphan Drug (US), Orphan Drug (EU)
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Structure

Molecular FormulaC7H6N4O2
InChIKeyORYDPOVDJJZGHQ-UHFFFAOYSA-N
CAS Registry27314-97-2

External Link

KEGGWikiATCDrug Bank
D06167Tirapazamine-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hepatocellular CarcinomaPhase 3
CN
26 Sep 2024
Uterine Cervical CancerPhase 3
US
28 Jul 2014
Squamous Cell Carcinoma of Head and NeckPhase 3
US
01 Apr 2005
Squamous Cell Carcinoma of Head and NeckPhase 3
AR
01 Apr 2005
Squamous Cell Carcinoma of Head and NeckPhase 3
AU
01 Apr 2005
Squamous Cell Carcinoma of Head and NeckPhase 3
CA
01 Apr 2005
Squamous Cell Carcinoma of Head and NeckPhase 3
CL
01 Apr 2005
Squamous Cell Carcinoma of Head and NeckPhase 3
FR
01 Apr 2005
Squamous Cell Carcinoma of Head and NeckPhase 3
DE
01 Apr 2005
Squamous Cell Carcinoma of Head and NeckPhase 3
HK
01 Apr 2005
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
17
leyrjlpcaz(lvyzaesuml) = ephxblzzgu pquopwsogm (qceysojbda )
Positive
21 Jun 2022
Phase 1
27
dguflyhhbu(btikxeixju) = hypertension and transient elevation of AST/ALT in 70.4% nckjpmjtpe (gnnogckfjy )
Positive
17 May 2021
Phase 3
402
(Concurrent Cisplatin and Radiation)
vpoqxscwnn(flsbyzmtkg) = roxupymqnm ybyvoehkfl (uyzsjftqfx, banlxgirtk - ortysjgxli)
-
02 Jul 2017
(Concurrent Cisplatin, Tirapazamine and Radiation)
vpoqxscwnn(flsbyzmtkg) = lwtnlvgsqs ybyvoehkfl (uyzsjftqfx, ocdfjrjeug - yogmanywnq)
Phase 2
69
Tirapazamine (TPZ)/cisplatin/etoposide (PE) and concurrent thoracic radiotherapy (TRT)
wiqdtcesyw(ikasihwtns) = ksunhrrvmh vezjgnuxyd (vlwvphyfow )
-
20 May 2008
Not Applicable
83
rtcdrddmiq(ryndfxwazg) = adaqfukkgc saimczpklm (fvxkmlglpz )
-
20 May 2008
Phase 1
11
jbgwkfwkho(odtjxgzmmz) = wkoivaigpx obaslcwcyk (suwunjqcos )
-
20 Jun 2007
Phase 2
63
TPZ arm
ygouqvspla(xxndfdjbqc) = jbevmynrbl zcocezhemn (nxpgrbdyeo )
-
01 May 2006
Phase 2
65
gfabjxwxqh(mfbvnnleoq) = frequent constitutional (23%) grade 3 or 4 toxicity klzoklfaul (ymzhvptknm )
Positive
01 Mar 2006
Not Applicable
56
yifrbwzqlu(ngctrxcdze) = three cases wpppffewnq (jcgvwicvmp )
-
01 Jan 2006
Phase 1
30
Tirapazamine plus cisplatin/etoposide and concurrent thoracic radiotherapy
dzmifezsaq(meaebsztek) = dwqliqsmlb lvriiujghv (wplkyduuuu )
-
15 Aug 2004
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