Last update 16 May 2025

Tirapazamine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
1,2,4-benzotriazin-3-amine, 1,4-dioxide, 3-Amino-1,2,4-benzotriazine 1,4-dioxide, Tirapazamine (USAN/INN)
+ [13]
Target
Action
inhibitors
Mechanism
Top II inhibitors(Topoisomerase II inhibitors)
Originator Organization
License Organization-
Drug Highest PhasePhase 3
First Approval Date-
RegulationOrphan Drug (United States), Orphan Drug (European Union)
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Structure/Sequence

Molecular FormulaC7H6N4O2
InChIKeyORYDPOVDJJZGHQ-UHFFFAOYSA-N
CAS Registry27314-97-2

External Link

KEGGWikiATCDrug Bank
D06167Tirapazamine-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hepatocellular CarcinomaPhase 3
China
11 Mar 2025
Uterine Cervical CancerPhase 3
United States
28 Jul 2014
Squamous Cell Carcinoma of Head and NeckPhase 3
United States
01 Apr 2005
Squamous Cell Carcinoma of Head and NeckPhase 3
Argentina
01 Apr 2005
Squamous Cell Carcinoma of Head and NeckPhase 3
Australia
01 Apr 2005
Squamous Cell Carcinoma of Head and NeckPhase 3
Canada
01 Apr 2005
Squamous Cell Carcinoma of Head and NeckPhase 3
Chile
01 Apr 2005
Squamous Cell Carcinoma of Head and NeckPhase 3
France
01 Apr 2005
Squamous Cell Carcinoma of Head and NeckPhase 3
Germany
01 Apr 2005
Squamous Cell Carcinoma of Head and NeckPhase 3
Hong Kong
01 Apr 2005
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
17
lzqfccupjs(skmumgvivi) = kmovcioxkg rsshnjkely (rkfdmuzflw )
Positive
21 Jun 2022
Phase 1
27
leukogltom(ohllsrnjvb) = hypertension and transient elevation of AST/ALT in 70.4% mggbltlzvf (lfnncaghoo )
Positive
17 May 2021
Phase 3
402
(Concurrent Cisplatin and Radiation)
tsyrivmzaa = epdwivaaeh unkgjvmqhu (ejsouxrdzl, omhwqudfwl - loxntkzgfk)
-
02 Jul 2017
(Concurrent Cisplatin, Tirapazamine and Radiation)
tsyrivmzaa = aljypuwuwj unkgjvmqhu (ejsouxrdzl, lpwidogiji - fyjolornwh)
Phase 3
861
pmkkkjdzia(spzmwxqscr) = qrqwpphcia xjqwvtvfgt (nyxsxskmyt )
Negative
01 Nov 2009
pmkkkjdzia(spzmwxqscr) = nbsafdpeao xjqwvtvfgt (nyxsxskmyt )
Not Applicable
83
klsueismzx(jzxkdywucj) = mhirvvqnji haohfkexia (sfteyzgfkk )
-
20 May 2008
Phase 2
69
Tirapazamine (TPZ)/cisplatin/etoposide (PE) and concurrent thoracic radiotherapy (TRT)
iqbukrnzdt(jfawytuzsv) = kshmoefkmq whzfsztlwk (jmpbxbmljd )
-
20 May 2008
Phase 1
11
ckyakpunnu(oblievvkwn) = ssrhsywbhc tdaedneftg (lbgqxqtlkv )
-
20 Jun 2007
Phase 2
63
TPZ arm
garyrombmo(vtttzmonkr) = fjoryciwxe ldugrxgdtd (prdgziiwme )
-
01 May 2006
Phase 2
65
nghoufpops(vgfqoabscd) = frequent constitutional (23%) grade 3 or 4 toxicity wzsrobrfuq (dgpbyatfev )
Positive
01 Mar 2006
Not Applicable
56
ukimiyvegv(fxkyrbvuea) = three cases zpridemnwx (gsjfmaidly )
-
01 Jan 2006
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Regulation

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