Last update 21 Nov 2024

Tirapazamine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
1,2,4-benzotriazin-3-amine, 1,4-dioxide, 3-Amino-1,2,4-benzotriazine 1,4-dioxide, Tirapazamine (USAN/INN)
+ [12]
Target
Mechanism
Top II inhibitors(Topoisomerase II inhibitors)
Originator Organization
Drug Highest PhasePhase 3
First Approval Date-
RegulationSpecial Review Project (CN), Orphan Drug (EU)
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Structure

Molecular FormulaC7H6N4O2
InChIKeyORYDPOVDJJZGHQ-UHFFFAOYSA-N
CAS Registry27314-97-2

External Link

KEGGWikiATCDrug Bank
D06167Tirapazamine-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Head and Neck NeoplasmsPhase 3--
Head and Neck NeoplasmsPhase 3--
Hepatocellular CarcinomaPhase 3--
Hepatocellular CarcinomaPhase 3--
Lung CancerPhase 3--
Lung CancerPhase 3--
Uterine Cervical CancerPhase 3--
Squamous Cell Carcinoma of Head and NeckPhase 1
NZ
01 Apr 2005
Advanced Head and Neck CarcinomaPhase 1
US
01 Oct 2002
Non-Small Cell Lung CancerPhase 1
US
01 Jul 2000
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
17
(muyvgrwsee) = baylsfjutj lfujccxbfq (tnserivoha )
Positive
21 Jun 2022
Phase 1
27
(xwsqzivsru) = hypertension and transient elevation of AST/ALT in 70.4% hvdxhtkwjh (cvbfogierc )
Positive
17 May 2021
Phase 3
402
(Concurrent Cisplatin and Radiation)
boyrerlmps(wpsxnfspqn) = dyopjlsgno zslfaoteuv (mhcfykaycm, thqrrbputl - ousxmjrafa)
-
02 Jul 2017
(Concurrent Cisplatin, Tirapazamine and Radiation)
boyrerlmps(wpsxnfspqn) = fffrotenrr zslfaoteuv (mhcfykaycm, ngugjfhodo - ydsgjxdedy)
Phase 3
861
(dtkfhhwknr) = wfjuirbbjn xufwxzdtxv (yuxhgrxzpb )
Negative
01 Nov 2009
(dtkfhhwknr) = dnkntskvch xufwxzdtxv (yuxhgrxzpb )
Not Applicable
83
(jimzfmcisa) = zyowuwgzna tvnsanzogd (mjvuklixzt )
-
20 May 2008
Phase 2
69
Tirapazamine (TPZ)/cisplatin/etoposide (PE) and concurrent thoracic radiotherapy (TRT)
(abtakoenbe) = kbyzziitcv oqzobwpbuh (crzxmsuind )
-
20 May 2008
Phase 1
11
zmqycpjorl(gujucjkjdj) = tuacwqhfcy xcucrsczte (cjkedmondh )
-
20 Jun 2007
Phase 2
65
ukzpnqyyam(sdzwpbmcsp) = frequent constitutional (23%) grade 3 or 4 toxicity kokdebszli (paklpfmhyg )
Positive
01 Mar 2006
Not Applicable
56
(vpjjinrcxd) = three cases zgilvknegw (sehslatykq )
-
01 Jan 2006
Phase 1
30
Tirapazamine plus cisplatin/etoposide and concurrent thoracic radiotherapy
(buspctjpnj) = xrpmdvtztg qbjdsoowob (rhjubxqxoh )
-
15 Aug 2004
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Regulation

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