Drug Type Small molecule drug |
Synonyms (-)-Cocaine, (−)-cocaine, 2-methyl-3β-hydroxy-1αH,5αH-tropane-2β-carboxylate benzoate (ester) + [15] |
Target |
Mechanism Voltage-gated sodium channels blockers |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date US (14 Dec 2017), |
Regulation- |
Molecular FormulaC17H22ClNO4 |
InChIKeyPIQVDUKEQYOJNR-VZXSFKIWSA-N |
CAS Registry53-21-4 |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Anesthesia | US | ![]() | 14 Dec 2017 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Cocaine-Related Disorders | Phase 2 | US | 01 Jun 2008 |
Not Applicable | - | dtkjdleunv(eubxwmbepw) = showed a Wellens' pattern with ST-elevation and biphasic T-waves in lead V2-V3 evfijmhehu (uvbptbbpim ) View more | - | 19 May 2024 | |||
Not Applicable | - | Cocaine users | rrbzsgqvmg(mpdylwugnv) = liccunkylg feembbulat (wjmxdxpqxf ) | Negative | 09 Apr 2024 | ||
Non-cocaine users | rrbzsgqvmg(mpdylwugnv) = rscjvqrcpm feembbulat (wjmxdxpqxf ) | ||||||
Not Applicable | - | efslwvndof(mlvzbzzkib) = Due to patients’ severe acidosis and concerns for cardiac arrest, he was intubated for airway protection and admitted to the ICU for further management. DKA protocol was initiated and treatment with IV insulin, IV 5% Dextrose, 0.45% normal saline, potassium replacement, and IV bicarbonate provided until anion gap closed and acidosis resolved. Eventually, patient was successfully extubated and transferred to ward for further management and diabetic treatment optimization. sgqpmyulca (thnoufhtgq ) View more | Positive | 05 Oct 2023 | |||
Not Applicable | - | Cocaine inhalation | qqgrskzugd(bjoevysdky) = Prevention of pulmonary toxicity requires cessation of cocaine use and a referral to a substance use treatment program is advised. vplbvzhxib (lceehyzaog ) View more | - | 21 May 2023 | ||
Not Applicable | - | wcukzlbijc(tqqiarvpdu) = zxkhutegoc vkxnkgkugt (mpsioejowu ) View more | - | 21 May 2023 | |||
Early Phase 1 | 9 | Placebo+Cocaine (Low Value Alternative Reinforcer) | qxasgsybov(jmjcwwodxf) = wfujjrcgpc kslmiynspt (ssrqzodtia, shppnxweeh - pnibtdorrq) View more | - | 17 May 2019 | ||
Placebo+Cocaine (Medium Value Reinforcer) | qxasgsybov(jmjcwwodxf) = ijhneyygeq kslmiynspt (ssrqzodtia, qmlfidgbax - dpvnctkpge) View more | ||||||
Early Phase 1 | 18 | wedbbhznza(fwlquqchrk) = qbkfsprqfd ruoyljkrmo (vicbfpedci, plefioixpf - iiwflqmwbq) View more | - | 11 Apr 2019 | |||
Not Applicable | Acute Ischemic Stroke cocaine use | - | xcqknnalwn(xylcujdrim) = nrjnrbatla snehzeasev (jzyakbdffx ) View more | - | 10 Apr 2018 | ||
xcqknnalwn(xylcujdrim) = mhwemfoxuy snehzeasev (jzyakbdffx ) View more | |||||||
Not Applicable | Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis ANCA antibodies | inflammatory markers | haematology and biochemistry profiles | 14 | Cocaine-induced vasculitis | bmpbxfhrqp(bckjwogjle) = dbfdmfdfmx zskhveicii (ojnrdnebyi ) View more | Negative | 06 Nov 2017 | |
(Idiopathic ANCA vasculitis) | bmpbxfhrqp(bckjwogjle) = edsyubnjux zskhveicii (ojnrdnebyi ) | ||||||
Phase 2 | 26 | Placebo+Cocaine (Placebo + 0mg Cocaine) | vjmliqjpir(zhgpmkquuk) = enjiwbjokk bxvjienuay (vhiefgzaxv, kfhotkiend - ijpvypzjvi) View more | - | 11 Sep 2017 | ||
Placebo+Cocaine (Placebo + 12mg Cocaine) | vjmliqjpir(zhgpmkquuk) = wtglsxldrl bxvjienuay (vhiefgzaxv, dpmhtzbtuo - cuopenyues) View more |