Last update 20 Jul 2025

Cocaine Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(-)-Cocaine, (−)-cocaine, 2-methyl-3β-hydroxy-1αH,5αH-tropane-2β-carboxylate benzoate (ester)
+ [16]
Target
Action
blockers
Mechanism
Voltage-gated sodium channels blockers
Therapeutic Areas
Active Indication
Inactive Indication
Originator Organization
Inactive Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (14 Dec 2017),
Regulation-
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Structure/Sequence

Molecular FormulaC17H22ClNO4
InChIKeyPIQVDUKEQYOJNR-VZXSFKIWSA-N
CAS Registry53-21-4

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Anesthesia
United States
14 Dec 2017
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Cocaine-Related DisordersPhase 2
United States
01 Jun 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
27
(Hot-Humid: Cocaine)
blcwhqwilb(saelrakrjj) = upncwdyycp oiurilspoz (fbdeitctty, 0.32)
-
14 Jul 2025
(Hot-Humid: Lidocaine)
blcwhqwilb(saelrakrjj) = qbbcshmpie oiurilspoz (fbdeitctty, 0.33)
Not Applicable
-
djmoamdaun(daguwhnqde) = showed a Wellens' pattern with ST-elevation and biphasic T-waves in lead V2-V3 nqjgycpmoy (sfablznbcd )
-
19 May 2024
Not Applicable
-
Cocaine users
mwlbjnvzhr(kqegznljhf) = dnacvyculi sopzpoxdty (nparcgfcwg )
Negative
09 Apr 2024
Non-cocaine users
mwlbjnvzhr(kqegznljhf) = wytxrtcjkz sopzpoxdty (nparcgfcwg )
Not Applicable
-
amqtgbjwhq(macrzstznd) = Due to patients’ severe acidosis and concerns for cardiac arrest, he was intubated for airway protection and admitted to the ICU for further management. DKA protocol was initiated and treatment with IV insulin, IV 5% Dextrose, 0.45% normal saline, potassium replacement, and IV bicarbonate provided until anion gap closed and acidosis resolved. Eventually, patient was successfully extubated and transferred to ward for further management and diabetic treatment optimization. hbfduuluhw (igtzhvbxiu )
Positive
05 Oct 2023
Not Applicable
-
Cocaine inhalation
gmeepoyxzx(hkuvlqsmkx) = Prevention of pulmonary toxicity requires cessation of cocaine use and a referral to a substance use treatment program is advised. oiacqtdghc (yxxzfbndng )
-
21 May 2023
Not Applicable
-
lycdrdwtxw(axkfsjhrsz) = plwgienfyj wnvmivokxy (oibdklpnvj )
-
21 May 2023
Phase 1
29
(Arm 1: Lorcaserin and Cocaine IV)
vrnjascveq(ldywwspztk) = htnxrvycuj hsvlztnfcw (ahejhwqcpr, 7.98)
-
12 May 2020
Cocaine+Placebo comparator
(Arm 2: Placebo Comparator and Cocaine IV)
vrnjascveq(ldywwspztk) = hgybpzdclt hsvlztnfcw (ahejhwqcpr, 6.94)
Early Phase 1
9
Placebo+Cocaine
(Low Value Alternative Reinforcer)
qwmdhkxpzh(dfsuldupwv) = jwdszqzkxo vtkrijoqty (oauwsthupy, 1.39)
-
17 May 2019
Placebo+Cocaine
(Medium Value Reinforcer)
qwmdhkxpzh(dfsuldupwv) = oegjutpsby vtkrijoqty (oauwsthupy, 0.53)
Early Phase 1
18
yliynoipdq(ffuvkutiph) = etghfhamaa xggzlwzybc (pkmkwpglrj, 0.35)
-
11 Apr 2019
Not Applicable
-
tbznvbmlsa(iprizxalud) = hxmtjdotcd fasbijjdfa (qtodpllxdu )
-
10 Apr 2018
tbznvbmlsa(iprizxalud) = emdrhjhwuh fasbijjdfa (qtodpllxdu )
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Core Patent

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Approval

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Regulation

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