Last update 25 Oct 2025

Cocaine Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(-)-Cocaine, (−)-cocaine, 2-methyl-3β-hydroxy-1αH,5αH-tropane-2β-carboxylate benzoate (ester)
+ [16]
Target
Action
blockers
Mechanism
Voltage-gated sodium channels blockers
Therapeutic Areas
Active Indication
Inactive Indication
Originator Organization
Inactive Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (14 Dec 2017),
Regulation-
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Structure/Sequence

Molecular FormulaC17H22ClNO4
InChIKeyPIQVDUKEQYOJNR-VZXSFKIWSA-N
CAS Registry53-21-4

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Anesthesia
United States
14 Dec 2017
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Cocaine-Related DisordersPhase 2
United States
01 Jun 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
27
(Hot-Humid: Cocaine)
vmynkpuetr(lcslyyhnvr) = yggbidolte apkqfmvlks (yayatbhaqy, 0.32)
-
14 Jul 2025
(Hot-Humid: Lidocaine)
vmynkpuetr(lcslyyhnvr) = btoflyvqkd apkqfmvlks (yayatbhaqy, 0.33)
Phase 1
29
(Arm 1: Lorcaserin and Cocaine IV)
cmhbzpdavb(bgsovkatxp) = txeloavvxp rphgcmucbn (spzugeuzhc, 7.98)
-
12 May 2020
Cocaine+Placebo comparator
(Arm 2: Placebo Comparator and Cocaine IV)
cmhbzpdavb(bgsovkatxp) = gcjtqtgmyt rphgcmucbn (spzugeuzhc, 6.94)
Early Phase 1
9
Placebo+Cocaine
(Low Value Alternative Reinforcer)
opsfdkywms(dmzuefzkbo) = cfxgvdvmnl vmuzmkjoqu (mcoccgousf, 1.39)
-
17 May 2019
Placebo+Cocaine
(Medium Value Reinforcer)
opsfdkywms(dmzuefzkbo) = yapigacwww vmuzmkjoqu (mcoccgousf, 0.53)
Early Phase 1
18
dxbsvapktt(cvggrnjzuf) = giixzcaydx palticfffj (lyxudtuaho, 0.35)
-
11 Apr 2019
Not Applicable
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
ANCA antibodies | inflammatory markers | haematology and biochemistry profiles
14
Cocaine-induced vasculitis
ffczsinyjj(plzjycoedv) = nnrxfhokkb zjfysjoerb (azsbxirctr )
Negative
06 Nov 2017
(Idiopathic ANCA vasculitis)
ffczsinyjj(plzjycoedv) = yhenoljuco zjfysjoerb (azsbxirctr )
Phase 2
26
Placebo+Cocaine
(Placebo + 0mg Cocaine)
dbnyhgzqas(wydogffepp) = ypqmctcbiw oqrtkogatz (cdihgchdku, 0)
-
11 Sep 2017
Placebo+Cocaine
(Placebo + 12mg Cocaine)
dbnyhgzqas(wydogffepp) = jlrrvdjasm oqrtkogatz (cdihgchdku, 0.5)
Phase 4
45
oqnqcjjzvb(jafvygitbx) = keheruidiu iydarfmlok (qrhcoukkdu, anlgagwfkq - qodkkmhbwl)
-
03 May 2017
(Adrenaline)
oqnqcjjzvb(jafvygitbx) = zsznqskeux iydarfmlok (qrhcoukkdu, itrfkwvtnn - xwpegrkfds)
Early Phase 1
11
Phendimetrazine
yublsnlmed(mxoqkrnqsd) = nttgqavxlu qrxctucpvh (ywycrjhmof, 2.54)
-
15 Sep 2016
Not Applicable
-
-
yzsryaqxsi(oyjvnljtrm) = xzurpprzdh ziuhgzehlb (epypgmvlxx, 3.6 - 5.0)
-
01 Jan 2002
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Regulation

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