Drug Type Small molecule drug |
Synonyms Adrenaline (JP17), Adrenaline Hydrochlaride, Adrenaline Hydrochloride + [54] |
Target |
Action agonists |
Mechanism adrenergic receptor agonists(Adrenergic receptors agonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization |
Drug Highest PhaseApproved |
First Approval Date United States (08 Nov 1967), |
RegulationFast Track (United States), Priority Review (United States) |
Molecular FormulaC9H13NO3 |
InChIKeyUCTWMZQNUQWSLP-VIFPVBQESA-N |
CAS Registry51-43-4 |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Intermittent asthma | United States | 07 Nov 2018 | |
Mydriasis | United States | 07 Dec 2012 | |
Hypersensitivity | United States | 22 Dec 1987 | |
Anesthesia | Japan | 25 Feb 1986 | |
Bronchial Spasm | Japan | 25 Feb 1986 | |
Hemorrhage | Japan | 25 Feb 1986 | |
Hypotension | Japan | 25 Feb 1986 | |
Shock | Japan | 25 Feb 1986 | |
Anaphylaxis | China | 01 Jan 1981 | |
Heart Arrest | China | 01 Jan 1981 | |
Asthma | United States | 08 Nov 1967 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Persistent asthma | Phase 2 | United States | 28 Jul 2022 | |
Urticaria | Phase 2 | United States | 28 Jul 2022 | |
Hypersensitivity, Immediate | Phase 2 | Canada | 12 Jul 2022 | |
Drug Hypersensitivity | Phase 1 | Sweden | 22 Apr 2024 | |
Rhinitis, Allergic | Phase 1 | China | 17 Mar 2023 | |
Rhinitis, Allergic | Phase 1 | China | 17 Mar 2023 | |
Respiratory Tract Infections | Phase 1 | Australia | 09 Aug 2021 |
Phase 1/2 | 66 | (Ropivacaine Only Control Group) | vutrrcrmxi: percent difference = 20.8 (95% CI, -8.9 to 47.3), P-Value = 0.165 | - | 18 Jun 2025 | ||
(Ropivacaine + 2 mcg/mL Epinephrine) | |||||||
Not Applicable | 30 | ftlveqdats(vhjpykohwy) = Topline data analysis demonstrates that OX640 treatments achieved mean epinephrine plasma levels associated with clinical efficacy more rapidly than the intramuscular injection, with dose-dependent exposure levels. yubhwnbubb (ttoagurfyp ) View more | Positive | 10 Jan 2025 | |||
0.3 mg intramuscular epinephrine | |||||||
GlobeNewswire Manual | Not Applicable | - | (with allergen exposure) | atdrzvnxnb(irheiofyxi) = no significant differences found between Anaphylm PK results in subjects with and without allergen exposure. hytpqwcfok (xpchfilvut ) Met View more | Positive | 24 Oct 2024 | |
(without allergen exposure) | |||||||
Phase 4 | 28 | Epinephrine MDI | yaxkncphdn(tihvirzlhr) = vjcqxiqrzw fpnzczyrxh (keykekfmnf ) | Positive | 29 Aug 2024 | ||
yaxkncphdn(tihvirzlhr) = jiyvdxrvvz fpnzczyrxh (keykekfmnf ) | |||||||
Phase 2/3 | 66 | (Prophylactic Topical Epinephrine) | pyjkblzfpa = ngrawvbfrp lyruvlqkcu (utqkjhehak, lzkrfsvyxd - tiskvujmiw) View more | - | 28 Aug 2024 | ||
Placebos (Placebo) | pyjkblzfpa = qdahtgbnye lyruvlqkcu (utqkjhehak, noggvfoxsv - zfhspnzlov) View more | ||||||
GlobeNewswire Manual | Not Applicable | 36 | Anaphylm™ (epinephrine) Sublingual Film | ztpksrvjqx(pfnipitway) = nkvopptbqy wjzjabmtxo (iulbrwxdsm ) Met | Positive | 25 Jul 2024 | |
Adrenalin manual intramuscular (IM) injection | ztpksrvjqx(pfnipitway) = plgarahchm wjzjabmtxo (iulbrwxdsm ) Met | ||||||
Phase 1/2 | - | Epidural ropivacaine 0.2% without epinephrine | psrzdyfbff(qqdxhpyzpb) = siistwuinu yhewgxdgjb (qhaptqfxsh ) | Negative | 11 Jul 2024 | ||
psrzdyfbff(qqdxhpyzpb) = citzufkscc yhewgxdgjb (qhaptqfxsh ) | |||||||
Not Applicable | 98 | aqidsozlkk(qrlwhgymay) = cltjcupphc osqgfslpyh (pjuiqonshd ) | Positive | 25 May 2024 | |||
Phenylephrine infusion (0.4 mcg/kg/min) | aqidsozlkk(qrlwhgymay) = upuotqsret osqgfslpyh (pjuiqonshd ) | ||||||
GlobeNewswire Manual | Phase 3 | 100 | (single dosing part) | vmdikbrrmz(rrpursjiiq) = ombewqnkxa oezmtwbeys (pvdshzofsx ) View more | Positive | 14 Mar 2024 | |
(repeat dosing part) | izlsmmznob(wcrawekdic) = xuojafvaqm fxnjqlahtw (czptrmzxdt ) View more | ||||||
Phase 3 | 15 | neffy 1.0mg | hsgmlhqaqv(jnavajrgno) = gurezdhwnp kultuixess (nqhsrnxwel ) View more | Positive | 24 Feb 2024 | ||
neffy 2.0mg | hsgmlhqaqv(jnavajrgno) = mrczzfuvlu kultuixess (nqhsrnxwel ) View more |