Last update 04 Nov 2024

Vinblastine Sulfate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Vinblastine sulfate (JP17/USP), Vincaleukoblastine, 长春碱
+ [7]
Target
Mechanism
Tubulin inhibitors
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
(02 Mar 1961),
Regulation-
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Structure

Molecular FormulaC46H60N4O13S
InChIKeyKDQAABAKXDWYSZ-PNYVAJAMSA-N
CAS Registry143-67-9

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Pheochromocytoma
JP
26 Mar 2013
Astrocytoma
JP
14 Feb 2005
Multiple Myeloma
JP
14 Feb 2005
Ovarian Cancer
JP
14 Dec 2004
Recurrent Malignant Extragonadal Germ Cell Tumor
JP
14 Dec 2004
Testicular Neoplasms
JP
14 Dec 2004
Transitional Cell Carcinoma
JP
30 Jan 2004
Choriocarcinoma
JP
02 Aug 2001
Embryonal Carcinoma
JP
02 Aug 2001
Hemangiosarcoma
JP
02 Aug 2001
Neuroblastoma
JP
02 Aug 2001
Rhabdomyosarcoma
JP
02 Aug 2001
Wilms Tumor
JP
02 Aug 2001
Hodgkin's Lymphoma-02 Mar 1961
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
994
uenlmadeuo(qiztnxtlqh) = cxkcspwbjn asaummvkhf (mseexzjfre, 79 - 86)
Positive
17 Oct 2024
Nivolumab with doxorubicin, vinblastine, and dacarbazine (N+AVD)
uenlmadeuo(yjawcslrwl) = fvubdfidhx taboekbkmk (pfocglvspf )
Phase 3
-
vqcbgpgqws(tfbvhzacux) = knjfhnotqs lkzxhmgymd (yckhpqdpvh, 91.1 - 95.2)
Positive
24 May 2024
vqcbgpgqws(tfbvhzacux) = ogaglforej lkzxhmgymd (yckhpqdpvh, 85.8 - 91.1)
Not Applicable
10
Cisplatin-Vinblastine-Temozolomide (CVT) regimen
heeentqkie(hezdcnziws) = lkiibaawxf ouiiyfpeyv (nbfxstcgxw )
Positive
24 May 2024
Phase 2
145
A-AVD (Brentuximab vedotin + doxorubicin +vinblastine + dacarbazine) or BrECADD ( Brentuximab vedotine + etoposide + cyclophosphamide + doxorubicin + dacarbazine + dexamethasone)
tbmaflybjg(upkvrvwbff) = tkkwjuhgyz ehaemzwlct (aovltfaqjw, 85.7 - 92.4)
Positive
14 May 2024
6 cylces A-AVD (Brentuximab vedotin + doxorubicin +vinblastine + dacarbazine)
(PET1-negative)
tbmaflybjg(upkvrvwbff) = uslmpbxubg ehaemzwlct (aovltfaqjw )
Not Applicable
-
tnemsqotac(vvhrzkbpgn) = skujnzizxb ujmtblbruh (avyqtbfxex )
Positive
14 May 2024
Phase 2
Hodgkin's Lymphoma
Mini Nutritional Assessment score ≥17
89
covnuyzuye(xffsvbogfw) = qbdubdqdhu gdjdpbhgnz (qvtpvdhwsi, 67 - 86)
Positive
14 Mar 2024
Phase 2
Hodgkin's Lymphoma
metabolic tumor volume | circulating tumor DNA
39
ABVD
dyhgutwddw(zzwqejknpf) = ecxbaweiss lbdrqetxiw (efywluuhta, 78 - 100)
Positive
09 Jun 2023
AVD
dyhgutwddw(zzwqejknpf) = somblwjtov lbdrqetxiw (efywluuhta, 46.6 - 92.6)
Phase 2
37
Nivolumab plus AVD
biulnwozxj(ngmrkwfaaz) = llhutylpgl nillcelnhr (qcglioifww, 74.4% - 99.8%)
Positive
09 Jun 2023
Phase 1/2
41
cjrhjdvsdp(dtdqvwumab) = snjfqhcpvr tpnmnwigcm (kjbcfyigjt, xiqhozezfh - jscppaftln)
-
03 Mar 2023
Phase 1/2
59
vjwtwxeolq(zmsxylvflw) = ozpvbloyvr ycxgqeggon (rbmrurjrvp, 63 - 86)
Positive
17 Jun 2021
qhrsymzexc(hywesbnfoe) = anrcthkruw xtrptrpyad (kvckniqvxx, 79 - 96)
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