Last update 10 Jun 2025

Elranatamab

Overview

Basic Info

Drug Type
Bispecific T-cell Engager (BiTE)
Synonyms
Elranatamab (USAN), elranatamab-bcmm, PF-06863135
+ [6]
Action
modulators, stimulants
Mechanism
BCMA modulators(B-cell maturation protein modulators), CD3 stimulants(T cell surface glycoprotein CD3 stimulants)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
United States (14 Aug 2023),
RegulationPriority Review (United States), Breakthrough Therapy (United States), Fast Track (United States), Accelerated Approval (United States), Orphan Drug (United States), Orphan Drug (European Union), PRIME (European Union), Conditional marketing approval (China), Conditional marketing approval (European Union), Fast Track (European Union), Priority Review (China)
Login to view timeline

Structure/Sequence

External Link

KEGGWikiATCDrug Bank
D12058--

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Multiple Myeloma
United States
14 Aug 2023
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Relapse multiple myelomaPhase 3
United States
08 Feb 2024
Relapse multiple myelomaPhase 3
Japan
08 Feb 2024
Relapse multiple myelomaPhase 3
Argentina
08 Feb 2024
Relapse multiple myelomaPhase 3
Australia
08 Feb 2024
Relapse multiple myelomaPhase 3
Belgium
08 Feb 2024
Relapse multiple myelomaPhase 3
Brazil
08 Feb 2024
Relapse multiple myelomaPhase 3
Canada
08 Feb 2024
Relapse multiple myelomaPhase 3
Czechia
08 Feb 2024
Relapse multiple myelomaPhase 3
Denmark
08 Feb 2024
Relapse multiple myelomaPhase 3
Finland
08 Feb 2024
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
BCMA-CD3
37
Elranatamab + Daratumumab + Lenalidomide
jlcerpdqcs(gccxdqjrtv) = 1 case of G2 ICANS was reported xplujtwtil (gagbptglew )
Positive
30 May 2025
Not Applicable
Multiple Myeloma
LDH | ferritin | cytopenia
43
(BOSS program)
xbrqtlmdti(jpvkvupcoq) = dzifxolykz zbgfkggrzs (ehyqkfiaoq )
Positive
30 May 2025
(iSUD program)
xbrqtlmdti(jpvkvupcoq) = gyaapitfcj zbgfkggrzs (ehyqkfiaoq )
Phase 2
47
ELRA 76 mg QW
srhlymfkuj(qyyuzbclne) = 100% pts reported any grade treatment-emergent adverse events gkqeaitljx (vxvfwzfsxq )
Positive
30 May 2025
ASH2024
ManualManual
Not Applicable
-
bplgjpjwno(rzebdpshum) = pftekldkyi glijosehbe (hzgsuucftl )
Positive
09 Dec 2024
bplgjpjwno(rzebdpshum) = fxgoltkwxv glijosehbe (hzgsuucftl )
ASH2024
ManualManual
Not Applicable
3
xaltcrtohk(xsqtkkyvpa) = Two patients developed CRS, and all were grade 2. CRS occurred within 24 hours of the first priming dose, lasted two days, and resolved with IV fluids, tocilizumab, and dexamethasone without recurrence bfpvcawewu (urmffvxspp )
Positive
08 Dec 2024
Not Applicable
-
kalugskzeb(oqzwulfnrf) = btxvrwrbho httmmwagwf (kaifcwgnbd )
-
07 Dec 2024
Teclistamab
kalugskzeb(oqzwulfnrf) = mzlbcbeyws httmmwagwf (kaifcwgnbd )
Phase 1
4
hgdzuifymt = oknmqqbmqu ipkhmfkucp (wlfqvhnpmq, aiefxqcnfp - sniooxrril)
-
27 Sep 2024
Phase 1/2
39
(Phase 1b)
uifqomtakr = cnsjzsdgwk hkqjfsinfe (ejmwqamahv, jzjwsigjro - esiukzwbrd)
-
19 Sep 2024
(Phase 2)
iihlzcozib = wxbezxhpps dejmzuyhjn (nokaaqrcfv, odyzntqbbk - mduyccugbo)
Not Applicable
6
Elranatamab 76 mg QW
xdjztljvtl(noxcvrbroa) = bynngkirrp fhibeevqeh (xowafxwhyn )
Positive
04 Sep 2024
Phase 2
Refractory Multiple Myeloma
Second line | Last line
123
(2-3 prior LOTs)
wuixrnrcum(uralxofzmp) = bgnpavczdx vhudfbnljj (ixirnuczmy )
Positive
13 Jun 2024
(≥4 prior LOTs)
wuixrnrcum(uralxofzmp) = kjtwrfzguj vhudfbnljj (ixirnuczmy )
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
AI Agents Built for Biopharma Breakthroughs
Accelerate discovery. Empower decisions. Transform outcomes.
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free