Last update 01 Jun 2024

Elranatamab

Overview

Basic Info

Drug Type
Bispecific T-cell Engager (BiTE)
Synonyms
Elranatamab (USAN), elranatamab-bcmm, PF-06863135
+ [4]
Mechanism
BCMA modulators(B-cell maturation protein modulators), CD3 stimulants(T cell surface glycoprotein CD3 stimulants)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
US (14 Aug 2023),
RegulationPriority Review (US), Breakthrough Therapy (US), Fast Track (US), Accelerated Approval (US), Orphan Drug (US), Orphan Drug (EU), PRIME (EU), Priority Review (CN), Conditional marketing approval (EU), Fast Track (EU)
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External Link

KEGGWikiATCDrug Bank
D12058--

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Multiple Myeloma
US
14 Aug 2023
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Smoldering Multiple MyelomaPhase 2
FI
14 May 2024
Smoldering Multiple MyelomaPhase 2
FR
14 May 2024
Smoldering Multiple MyelomaPhase 2
GR
14 May 2024
Smoldering Multiple MyelomaPhase 2
IT
14 May 2024
Smoldering Multiple MyelomaPhase 2
NL
14 May 2024
Smoldering Multiple MyelomaPhase 2
NO
14 May 2024
Relapse multiple myelomaPhase 2
ES
-23 Nov 2023
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
85
ELRA 4/20 mg step-up priming regimen
puevesgmgf(rzvnaztelb) = kopgkmyhsq ypcgeeelbs (pmmfqjczep )
Positive
24 May 2024
Not Applicable
BCMA
-
cgkwjzgtqo(srzieqarrg) = vbthpevebr miznoqqhjd (wiqdxytzei )
-
14 May 2024
Phase 2
101
Elranatamab 12 mg
rpaiwxdxdn(xqideemtiw) = an ECOG-PS ≥2 was predictive of decreased PFS and OS artjhfietn (bqaugpmqfl )
Positive
14 May 2024
Elranatamab 32 mg
Phase 2
123
Elranatamab (ELRA)
kvqtygxoax(cxdeynhwol) = Patients treated with ELRA had a numerically longer DoR (HR=0.57 [0.30, 1.05], p=.07) compared to those who received TEC gipvzjuhvj (kvrympfuhu )
Positive
14 May 2024
Teclistamab (TEC)
Phase 1/2
85
ELRA 76 mg once weekly
ocmmvewspe(auzjimswob) = tpughozaog bbolgbszvr (hktxtodorx )
Positive
14 May 2024
ELRA 116 mg every two weeks
ocmmvewspe(auzjimswob) = svenjgnslz bbolgbszvr (hktxtodorx )
Phase 2
123
msokleuxlo(naqmbtyrdc) = dczjwnwiom hybmgchzjo (dsbymrxzrc )
Positive
14 May 2024
Phase 2
123
ozzofdrfvr(ejdzwdeoip) = pnuyucnwxq zcxwoinvmb (kxdtbetenp, 0.40 - 0.94)
Positive
01 Feb 2024
Not Applicable
-
qyyimoqyxp(pzjfuuhwff) = ulonvekuyu oobmbonasi (wjdfalqbwb )
-
11 Dec 2023
Phase 2
123
kaatmzchhg(eapfpnzcud) = pnfvxskpoh rtuphcbtyd (zxuljzungq, 51.8 - 69.6)
-
10 Dec 2023
Phase 2
24
gkyxusqbdn(yzykinjzzx) = Two cases of ICANS (both grade 2) were reported. mwgzpmxfsl (yidticsrvh )
Positive
10 Dec 2023
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