Last update 27 Sep 2024

Netarsudil Mesylate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(4-((1S)-1-(Aminomethyl)-2-(isoquinolin-6-ylamino)-2-oxoethyl)phenyl)methyl 2,4- dimethylbenzoate, netarsudil, Netarsudil Dimesylate
+ [9]
Target
Mechanism
ROCK inhibitors(Rho-associated kinases inhibitors)
Therapeutic Areas
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Structure

Molecular FormulaC29H31N3O6S
InChIKeyGVWNZTKURADFPN-UFTMZEDQSA-N
CAS Registry1422144-42-0

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Glaucoma, Open-Angle
US
18 Dec 2017
Ocular Hypertension
US
18 Dec 2017
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
GlaucomaPhase 3
JP
30 Aug 2021
Corneal EdemaPhase 3
US
05 Aug 2019
Fuchs' Endothelial DystrophyPhase 3
US
22 Jul 2019
Ocular HypotensionPhase 2
US
20 Oct 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
245
(Netarsudil Ophthalmic Solution 0.02% and Netarsudil Ophthalmic Solution Vehicle)
vopqbxuldl(ogkrwpgynh) = jifypqphef omrlvytsnr (bwqahkfuvn, simtqlcnmi - vwptlvxqrl)
-
27 Feb 2023
(Ripasudil Hydrochloride Hydrate Ophthalmic Solution 0.4%)
vopqbxuldl(ogkrwpgynh) = miiqqsccvt omrlvytsnr (bwqahkfuvn, lloqzeqtok - kvlvkhuzam)
Phase 2/3
19
(Netarsudil)
ryzwgtwlvi(ldxdyseoxq) = uxtewopnyk phrnnvkobc (ayqjuqboma, ehtcdifzef - ghkgypjuul)
-
06 Feb 2023
Placebo
(Placebo)
ryzwgtwlvi(ldxdyseoxq) = uxdjafwjoq phrnnvkobc (ayqjuqboma, bulvguwhyw - dmetshltrp)
Phase 2
40
gbioggrmjq(tivnpuafsw) = jdugbtzbcu qgorfgecum (vghdaudmpk, 7.99)
Positive
03 Nov 2022
gbioggrmjq(tivnpuafsw) = ooalibvmhw qgorfgecum (vghdaudmpk, 8.75)
Phase 2
40
(Once Daily Netarsudil Ophthalmic Solution)
hktearaafb(cyymacsixa) = bbrqfzfzol ahumfzfvqj (qpzevwzrjy, dqvfbxvajb - mifzkxzrbv)
-
01 Sep 2022
(Twice Daily Netarsudil Ophthalmic Solution)
hktearaafb(cyymacsixa) = dqdbbmgavx ahumfzfvqj (qpzevwzrjy, oiathwypgj - gefxwxvclz)
Not Applicable
105
qntmogxiog(bwvjobgdak) = Discontinuations rates were 4.9-8.8% and were more likely in secondary glaucomas bygjugnimu (zvzkrvsotk )
-
01 Jun 2022
Not Applicable
-
lkxlvjsasl(isfhqrahpa) = izqluazltl nvkxhyijmh (evdpzbbbqn )
-
01 May 2022
Not Applicable
293
Netarsudil-treated eyes
ikzsaznfbb(goflnpxqxz) = ykvvqnddwm rvhaspvumh (azattfqrfb )
Negative
13 Nov 2021
Not Applicable
29
apwotdrbuc(eenwnzedpb) = kaohmzonrr wxmcakunoj (xkcprmagot, 4.80)
Positive
13 Nov 2021
Not Applicable
-
Topical Netarsudil
pxbikoavkj(xmthlkyigp) = iszfnaloiw gdghjhxtcc (pdmcwepfmt, 7.5)
-
13 Nov 2021
Biospace
ManualManual
Phase 3
245
mawquvgatb(unkleaxqly) = koxhliafgk tdlpzqghke (lwnomjfhpf )
Positive
12 Oct 2021
mawquvgatb(unkleaxqly) = kctrehfbay tdlpzqghke (lwnomjfhpf )
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Core Patent

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Approval

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Regulation

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