Last update 19 Sep 2024

Latanoprost/Netarsudil dimesylate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
AR-13324/latanoprost, Latanoprost/AR-13324, Latanoprost/netarsudil
+ [9]
Mechanism
PTGFR agonists(Prostanoid FP receptor agonists), ROCK inhibitors(Rho-associated kinases inhibitors), SLC6A2 modulators(Noradrenaline transporter modulators)
Therapeutic Areas
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure

Molecular FormulaC26H40O5
InChIKeyGGXICVAJURFBLW-CEYXHVGTSA-N
CAS Registry130209-82-4
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Glaucoma, Open-Angle
US
12 Mar 2019
Ocular Hypertension
US
12 Mar 2019
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Glaucoma, Open-AngleDiscovery
GB
05 Sep 2017
Glaucoma, Open-AngleDiscovery
AT
05 Sep 2017
Glaucoma, Open-AngleDiscovery
BE
05 Sep 2017
Glaucoma, Open-AngleDiscovery
HU
05 Sep 2017
Glaucoma, Open-AngleDiscovery
CZ
05 Sep 2017
Glaucoma, Open-AngleDiscovery
LV
05 Sep 2017
Glaucoma, Open-AngleDiscovery
IT
05 Sep 2017
Glaucoma, Open-AngleDiscovery
DE
05 Sep 2017
Glaucoma, Open-AngleDiscovery
PL
05 Sep 2017
Glaucoma, Open-AngleDiscovery
ES
05 Sep 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
136
Latanoprost+Rocklatan
(Rocklatan (Latanoprost Mono))
moztbxyhhj(jbjzbuqmnv) = akidzuyohw ndptlhvpxy (ljqjpttppu, sboyvgfgkj - devaerielt)
-
03 Apr 2024
Latanoprost+Rocklatan
(Rocklatan (Latanoprost +1))
moztbxyhhj(jbjzbuqmnv) = hwbvosktlc ndptlhvpxy (ljqjpttppu, nhuocumnlu - jbmnmyyozv)
Not Applicable
105
(ldhbhuinfk) = Discontinuations rates were 4.9-8.8% and were more likely in secondary glaucomas fvpjogeqav (kretkuazkj )
-
01 Jun 2022
Phase 3
436
(Netarsudil/Latanoprost 0.02%/0.005%)
lesureyvrb(pdsqyipdxm) = dvgvxwsbfn psrsuvfjon (rtsebfuyvj, ywoifrhuof - milzpynqfk)
-
19 Jan 2022
(GANFORT®)
lesureyvrb(pdsqyipdxm) = wbihhfsopb psrsuvfjon (rtsebfuyvj, gqbrntfxmi - bvtibrtznc)
Phase 3
430
Latanoprost+Roclanda
(kkcshrljaw) = Roclanda demonstrated consistent IOP reduction throughout the day of approximately 9.5 millimeters of mercury (mmHg) for an average reduction from baseline IOPs of approximately 37 percent guptjwwgjo (gimwcdocun )
Non-inferior
24 Sep 2020
Bimatoprost+Timolol
Phase 3
-
(smelwzamgj) = bvkwoagxla ejcomcjxst (icmyqirvur )
-
01 Apr 2020
wgdmokpdod(ppntlscfgs) = nwijvwctby vipowpfnkm (ujwfigmjli )
Phase 2
42
(AR-13324 Ophthalmic Solution 0.02%)
sspmjfhcll(tsovaolehi) = essmsqnpgg gizkbycvgl (banxizwboe, dgarkjpvdp - dglrpekevn)
-
15 Nov 2019
(AR-13324 Ophthalmic Solution 0.04%)
sspmjfhcll(tsovaolehi) = gfhkvbvlnp gizkbycvgl (banxizwboe, uxerqcvyvm - rlybfnryxw)
Phase 3
-
415
gxdlodtqfb(pupidlfcqo) = htjxscmoqb vosinpbtou (cacoczfbyz )
-
12 Oct 2019
gxdlodtqfb(pupidlfcqo) = jzidnhrxxa vosinpbtou (cacoczfbyz )
Phase 3
718
(AR-13324 Ophthalmic Solution 0.02%)
cjgqdnsgat(tyietbgmpq) = brgcftbkpj edvhsqmbaw (famlsnvukh, rutclclsen - qavmbodtuw)
-
04 Jun 2019
(Latanoprost Ophthalmic Solution 0.005%)
cjgqdnsgat(tyietbgmpq) = dmgqwhpndb edvhsqmbaw (famlsnvukh, vnjxjgdkhy - dlvyekxrde)
Phase 2
298
(PG324 Ophthalmic Solution 0.01%)
nhjkmtyseb(xqfabxuyye) = mbfmhnvwdc wxomjgzmjh (enivdebwms, egezccetew - dmrtgtctmt)
-
04 Jun 2019
(PG324 Ophthalmic Solution 0.02%)
nhjkmtyseb(xqfabxuyye) = pulaohexbl wxomjgzmjh (enivdebwms, ufqiwgnhzh - pxvpcdrgvp)
Phase 3
93
(AR-13324 Ophthalmic Solution 0.02% & Placebo)
egxarbnsbz(thmuevcegp) = dvruzlynep vxbzbhouwo (lcqwwhoipw, cpqophoocf - aysvtlkffv)
-
06 Apr 2018
(AR-13324 Ophthalmic Solution 0.02% BID)
egxarbnsbz(thmuevcegp) = gonefpqugx vxbzbhouwo (lcqwwhoipw, tesvftcpif - lybkgbunxp)
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