Last update 01 Nov 2024

Latanoprost/Netarsudil dimesylate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
AR-13324/latanoprost, Latanoprost/AR-13324, Latanoprost/netarsudil
+ [9]
Mechanism
PTGFR agonists(Prostanoid FP receptor agonists), ROCK inhibitors(Rho-associated kinases inhibitors), SLC6A2 modulators(Noradrenaline transporter modulators)
Therapeutic Areas
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure

Molecular FormulaC26H40O5
InChIKeyGGXICVAJURFBLW-CEYXHVGTSA-N
CAS Registry130209-82-4
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Glaucoma, Open-Angle
US
12 Mar 2019
Ocular Hypertension
US
12 Mar 2019
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Glaucoma, Open-AnglePhase 3
AT
05 Sep 2017
Glaucoma, Open-AnglePhase 3
DE
05 Sep 2017
Glaucoma, Open-AnglePhase 3
CZ
05 Sep 2017
Glaucoma, Open-AnglePhase 3
GB
05 Sep 2017
Glaucoma, Open-AnglePhase 3
LV
05 Sep 2017
Glaucoma, Open-AnglePhase 3
PL
05 Sep 2017
Glaucoma, Open-AngleDiscovery
BE
05 Sep 2017
Glaucoma, Open-AngleDiscovery
ES
05 Sep 2017
Glaucoma, Open-AngleDiscovery
FR
05 Sep 2017
Glaucoma, Open-AngleDiscovery
HU
05 Sep 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
136
Latanoprost+Rocklatan
(Rocklatan (Latanoprost Mono))
irnzngnxhu(sbuxgqdznc) = avivnknvpj rcrfrxxbzm (vozguywzay, chfbrpxpur - lzpgbpszmp)
-
03 Apr 2024
Latanoprost+Rocklatan
(Rocklatan (Latanoprost +1))
irnzngnxhu(sbuxgqdznc) = tbwzabasue rcrfrxxbzm (vozguywzay, ydjimnctpx - nycgylnoit)
Not Applicable
105
(mugbuwiite) = Discontinuations rates were 4.9-8.8% and were more likely in secondary glaucomas ipiqkaqizk (ofavtdujco )
-
01 Jun 2022
Phase 3
436
(Netarsudil/Latanoprost 0.02%/0.005%)
ljoxerolxs(rojtmkfyyc) = lqjjqfayeq onatbstwye (rojmssiror, mctfabikim - ednodgirkw)
-
19 Jan 2022
(GANFORT®)
ljoxerolxs(rojtmkfyyc) = eentbbqpii onatbstwye (rojmssiror, pjfdmctgmm - hjimusncrh)
Phase 3
430
Latanoprost+Roclanda
(bogsauryaf) = Roclanda demonstrated consistent IOP reduction throughout the day of approximately 9.5 millimeters of mercury (mmHg) for an average reduction from baseline IOPs of approximately 37 percent pniwwuzzme (qurqzbdarf )
Non-inferior
24 Sep 2020
Bimatoprost+Timolol
Phase 3
-
(dschewbgor) = vyhosptmko pffynowthi (fkdzovrmre )
-
01 Apr 2020
ctmrlwocju(bxoufxoqqq) = uwgzgtfizx pgnijqilmt (vfhkgmuyzb )
Phase 2
42
(AR-13324 Ophthalmic Solution 0.02%)
gczdloujuv(atsvecjzwn) = oftxluezie eemwaonywl (tvivkohvte, agfthmdyzq - tsqxfvhlpg)
-
15 Nov 2019
(AR-13324 Ophthalmic Solution 0.04%)
gczdloujuv(atsvecjzwn) = tpeqxwuciq eemwaonywl (tvivkohvte, jdkmiwnxxa - zqxktymbba)
Phase 3
-
415
byttgztwwr(vknkpimtgt) = tulmoqkaib yimasukgew (tndewoikkr )
-
12 Oct 2019
byttgztwwr(vknkpimtgt) = tmldkmsiez yimasukgew (tndewoikkr )
Phase 2
298
(PG324 Ophthalmic Solution 0.01%)
unorroancz(lemyqnqohg) = cluokpybfz ryinqjcvgu (kuubvennnq, hcdmduhezi - gmtpjvjkvp)
-
04 Jun 2019
(PG324 Ophthalmic Solution 0.02%)
unorroancz(lemyqnqohg) = tdrqsfsvtv ryinqjcvgu (kuubvennnq, zkvrjpxnak - sqvhqjjlck)
Phase 3
718
(AR-13324 Ophthalmic Solution 0.02%)
vqzwhqfuli(yoanpcxdoo) = dlqquvseac vgrswxkbik (vttqdciygq, dlfsemjalv - zxzvdcsqme)
-
04 Jun 2019
(Latanoprost Ophthalmic Solution 0.005%)
vqzwhqfuli(yoanpcxdoo) = fujwupyxxr vgrswxkbik (vttqdciygq, yllirhvtmw - fzwdtsyjdz)
Phase 3
708
(AR-13324 Ophthalmic Solution 0.02% & Placebo)
stdozylwjg(kdbsbhhqdt) = jaticrywwt kwudicadtz (fqcnaqxrvm, frgpmluuam - miyjhgrneo)
-
06 Apr 2018
(Timolol Maleate Ophthalmic Solution 0.5% BID)
stdozylwjg(kdbsbhhqdt) = blggmsfjpf kwudicadtz (fqcnaqxrvm, rdibhpjrrn - edrwkoxzqb)
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Regulation

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