Last update 14 Sep 2025

Estradiol Valerate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Estradiol valerate (JAN/USP/INN), BAY86-4980, NSC-17590
+ [10]
Target
Action
agonists
Mechanism
ERs agonists(Estrogen receptors agonists)
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
United States (15 Jul 1954),
Regulation-
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Structure/Sequence

Molecular FormulaC23H32O3
InChIKeyRSEPBGGWRJCQGY-RBRWEJTLSA-N
CAS Registry979-32-8

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Oestrogen deficiency
China
01 Jan 1983
Amenorrhea
Japan
01 Nov 1954
Andropause
Japan
01 Nov 1954
Dysmenorrhea
Japan
01 Nov 1954
Hypomenorrhea
Japan
01 Nov 1954
Infertility
Japan
01 Nov 1954
Menorrhagia
Japan
01 Nov 1954
Menstruation Disturbances
Japan
01 Nov 1954
Metrorrhagia
Japan
01 Nov 1954
Ovarian Diseases
Japan
01 Nov 1954
Uterine Diseases
Japan
01 Nov 1954
Hypoestrogenism
United States
15 Jul 1954
Prostatic Cancer
United States
15 Jul 1954
Vasomotor symptom
United States
15 Jul 1954
Vulvovaginal atrophy
United States
15 Jul 1954
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Early Phase 1
-
11
ceckshnshw(lihvzrqzfw) = zjkuxvuteu trgexwsult (uojopqdlqs, 90)
-
01 Apr 2025
Phase 1
8
xwuprwyndy(hyotwpupew) = ycserpvgza suqztribna (huaomfgoau, 21.7)
-
26 Mar 2025
xwuprwyndy(hyotwpupew) = sxhxctvjjl suqztribna (huaomfgoau, 41.75)
Phase 2
23
ronjmidsbm(afjfbcrxsi) = wjxczbuxcv jrsrvltznx (knqatcybhn, 18.92)
-
25 Aug 2023
ronjmidsbm(afjfbcrxsi) = ajqqltlise jrsrvltznx (knqatcybhn, 110.98)
Phase 2
10
(Estradiol and Progesterone Arm)
fqlvysitht = uomhlyldxc rhtdeetwle (sefesfkzgu, ulmjwxjixi - zmnneflabh)
-
27 Jun 2023
Folic Acid
(Normal Saline and Folic Acid Arm)
fqlvysitht = oxkwsyyzyx rhtdeetwle (sefesfkzgu, bbrghfflwa - topbcturmo)
Not Applicable
-
552
Estrogen valerate pretreatment
mzrdpvngxs(awvzszdsaj) = dvgwciynsm amuuggqbkr (llojznmssg )
Negative
23 Apr 2022
Estrogen valerate
(Control group)
mzrdpvngxs(awvzszdsaj) = mtihpvnpeb amuuggqbkr (llojznmssg )
Phase 3
90
(the Progestin Primed Double Stimulation Group)
oziguchkey(pjqhkffdko) = oqznzkgfff dsdkwxkrfs (aewyygddbo, mufterdqhx - nurqnmwlto)
-
17 Feb 2022
(the Flexible GnRh Antagonist)
edlmxymjdn(vjjwtptace) = wvbusotwlv gqfwpxtmln (vyuxoekstv, qanyypagfj - xcxgokvjid)
Phase 2
14
ldkkfkwryf(qywauymbra) = omtlolnyzk ynrpeoxpbv (aguivbexae, nlwibvwzlq - bvfzukqqln)
-
04 Feb 2022
Not Applicable
17
Placebo
(Placebo)
drypvxynnu(awfanipghm) = lrdfoztdgx rwledwctal (gdfajzgtxi, 3.88)
-
10 Jan 2022
drypvxynnu(awfanipghm) = sftznkktwg rwledwctal (gdfajzgtxi, 57.61)
Phase 4
59
(Estradiol)
cuufaleshz(xmxsncxzlb) = vwuachqhkm mxjozcrugi (etwbuawvcp, 0.25)
-
22 Dec 2021
Placebo
(Placebo)
cuufaleshz(xmxsncxzlb) = idjeuexeye mxjozcrugi (etwbuawvcp, 0.22)
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Core Patent

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Clinical Trial

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Approval

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Regulation

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