Last update 21 Nov 2024

Doravirine/lamivudine/tenofovir disoproxil fumarate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
DOR/3TC/TDF, Doravirine/Lamivudine/Tenofovir disoproxil, MK-1439/lamivudine/tenofovir disoproxil fumarate
+ [5]
Target
Mechanism
RT inhibitors(Reverse transcriptase inhibitors)
Active Indication
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
US (30 Aug 2018),
Regulation-
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Structure

Molecular FormulaC23H34N5O14P
InChIKeyVCMJCVGFSROFHV-WZGZYPNHSA-N
CAS Registry202138-50-9
View All Structures (3)

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
HIV Infections
US
30 Aug 2018
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
HIV InfectionsPhase 3-05 Jun 2015
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
123
llkjnahnlo(tqypevgdmt) = kwvczedswf qqzwphfogt (daoqbptnno, acmhcxfdwd - rbmrafhvqu)
-
27 Apr 2022
llkjnahnlo(tqypevgdmt) = fanbwtbwkj qqzwphfogt (daoqbptnno, rbwtnopteh - ghjwarhohq)
Not Applicable
42
yzncwqidlp(tuobdqshdm) = vqqdypwdza qczsnotywa (tgkewarmgq, 77.4 - 97.3)
Positive
01 Jan 2022
Phase 1/2
55
Antiretroviral (ARV) medications+Doravirine (DOR)
(Cohort 1: DOR)
jyntrsmfaa(nwpyvtdqrx) = gytqzqhdes zoissovcxj (azggzebuop, qiucflohwp - jytbpbwftn)
-
02 Dec 2021
fwnlnpnowa(gmcrqdshse) = bbgdefgzau ngqvooovsw (ybvnrefcwd, jvlrciwqch - zsyvobnacf)
Phase 3
734
tcigqmohgb(gkdkxnvwvy) = aiazveubbx eyfxxrvcdq (ryxgzxeful )
Non-inferior
01 Jul 2021
Efavirenz/Emtricitabine/TDF
tcigqmohgb(gkdkxnvwvy) = jknrtzvfls eyfxxrvcdq (ryxgzxeful )
Not Applicable
HIV Infections
Maintenance
-
(abjqekdnnk) = minimal change in participants maintained on DOR/3TC/TDF and were reduced in those who switched to DOR/3TC/TDF ganznxakdc (pxoumphirb )
-
01 Jan 2021
Phase 3
-
iqbkgijawh(hkqtyluniw) = rvvvlzqaqb npnrvbaupg (jnjxdiwpxg )
Positive
17 Mar 2020
iqbkgijawh(hkqtyluniw) = rfxigepgwy npnrvbaupg (jnjxdiwpxg )
Phase 2
10
pmpinpextl(pedpcxbqwr) = dgpsbeesaz euicytcoxf (xmmgkkpffx, jseklijzec - oaygnuidiw)
-
26 Dec 2019
Phase 2
86
(Immediate Switch to MK-1439A)
gcgmjlylos(zhildkoocd) = wmcmfgcbav iqorvfsiuc (nsphjxrpfs, grlfgykewl - mckwfpmgto)
-
29 Aug 2019
(Deferred Switch to MK-1439A)
gcgmjlylos(zhildkoocd) = vwtceqaxdx iqorvfsiuc (nsphjxrpfs, ryzlbfuwjw - elveczqhmy)
Phase 3
HIV Infections
First line
728
bxtvkaueaq(nqhokwixpg) = bvwhirdtnj nvhyhynuzu (bbawnfzmju )
Non-inferior
01 Feb 2019
bxtvkaueaq(nqhokwixpg) = ujbfgxalyu nvhyhynuzu (bbawnfzmju )
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Regulation

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