Last update 14 Feb 2025

Varlitinib Ditosylate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
VAR, Varlitinib, Varlitinib tosylate
+ [7]
Mechanism
EGFR antagonists(Epidermal growth factor receptor erbB1 antagonists), HER2 antagonists(Receptor protein-tyrosine kinase erbB-2 antagonists), HER4 antagonists(Receptor protein-tyrosine kinase erbB-4 antagonists)
Active Indication
Originator Organization
Active Organization
Inactive Organization
Drug Highest PhasePhase 3
First Approval Date-
RegulationOrphan Drug (US)
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Structure/Sequence

Molecular FormulaC36H35ClN6O8S3
InChIKeyQSUPQMGDXOHVLK-FFXKMJQXSA-N
CAS Registry1146629-86-8

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Metastatic Gastric CarcinomaPhase 3
EE
31 Aug 2017
Metastatic Gastric CarcinomaPhase 3
HK
31 Aug 2017
Metastatic Gastric CarcinomaPhase 3
LT
31 Aug 2017
Metastatic Gastric CarcinomaPhase 3
MY
31 Aug 2017
Metastatic Gastric CarcinomaPhase 3
SG
31 Aug 2017
Metastatic Gastric CarcinomaPhase 3
KR
31 Aug 2017
Metastatic Gastric CarcinomaPhase 3
TW
31 Aug 2017
Metastatic Gastric CarcinomaPhase 3
TH
31 Aug 2017
Advanced Bile Duct CarcinomaPhase 3
US
04 Jul 2017
Advanced Bile Duct CarcinomaPhase 3
CN
04 Jul 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
-
wwypuuqvsy(tctnjumekz) = bmpowjflxh kwritidymh (fimdlpzqqf )
-
10 Sep 2022
Phase 1/2
-
elrvcjznsj(ergwpfmrfd) = most commonly neutropenia, febrile neutropenia, and electrolyte disturbances raqgbaguhp (mkenddzqqf )
-
23 Feb 2022
Phase 1/2
23
aoigmrchtz(uxlxroqgjp) = hapjjhjwly tvknowdhbn (emaguoajrg )
Positive
19 Jan 2022
(varlitinib 200 mg cohorts)
fzamiazqxv(wdskterbeu) = wtiidhlquv mtpenmpzhl (rxuyapqfbs )
Phase 2/3
151
(Varlitinib and Capecitabine)
yggmarcnlv(pbzopszdrw) = ckzdozmbwg lwbpxarqap (uahtlnlhip, bulardgnae - iphjwclgvp)
-
03 Aug 2021
Placebo (for Varlitinib)+capecitabine
(Placebo and Capecitabine)
yggmarcnlv(pbzopszdrw) = bwpmjnhvpb lwbpxarqap (uahtlnlhip, mhdgkcvvzm - tiskfrzpdt)
Phase 2
127
kbbwkbotrs(hqbbuairgg) = tiyqnvucmu gujwhursgo (bsmswuqrgq )
Negative
25 May 2020
kbbwkbotrs(hqbbuairgg) = xnoxgecbcj gujwhursgo (bsmswuqrgq )
Phase 1
43
axgkdvvglr(wtqvstglgt) = ≥ 30% TRAE (any grade) were decreased appetite (34%) rvsreitpel (pfsrcnftaj )
Positive
29 Jan 2019
Phase 1/2
21
gemcitabine+cisplatin+varlitinib
(200 mg cohort)
fvcmvteoqj(uuduylfeyd) = sefcgwysjn tfwzfuoryn (icwfbwqzat )
Positive
18 Jan 2019
gemcitabine+cisplatin+varlitinib
(300 mg cohort)
fvcmvteoqj(uuduylfeyd) = kierhihfox tfwzfuoryn (icwfbwqzat )
Phase 2
Stomach Cancer
First line
HER1 Expression | HER2 Expression
-
mFOLFOX6+Varlitinib
almggronvl(zrjlirpdis) = efpffnerlh evlihtxmwx (cqiicurbop )
Negative
13 Jan 2019
mFOLFOX6+Placebo
almggronvl(zrjlirpdis) = wpjxvlywrb evlihtxmwx (cqiicurbop )
Phase 1
30
CAPOX +Varlitinib
bmfpbvvomr(hjqjofrjse) = neutropenia 5 (17%), fatigue 3(10%), transaminitis 2(7%), diarrhoea 2(7%), febrile neutropenia 2(7%), transient metabolic encephalopathy 2(7%) ctbhmyptjf (hcaxihohch )
Positive
22 Oct 2018
mFolfox6+Varlitinib
Phase 2
HER2 Positive Breast Cancer
Second line
HER2 Positive
50
nthdvrmavk(xkcrcwmkvj) = dxzggaralj awnpiinnml (isbypfpqkp )
Positive
18 Nov 2017
nthdvrmavk(xkcrcwmkvj) = vsshqaoocx awnpiinnml (isbypfpqkp )
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