Last update 21 Nov 2024

Voruciclib Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Voruciclib
+ [3]
Mechanism
CDK4 inhibitors(Cyclin-dependent kinase 4 inhibitors), CDK6 inhibitors(Cyclin-dependent kinase 6 inhibitors), CDK9 inhibitors(Cyclin-dependent kinase 9 inhibitors)
Inactive Indication
Originator Organization
Active Organization
Inactive Organization
Drug Highest PhasePhase 1
First Approval Date-
Regulation-
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Structure

Molecular FormulaC22H19ClF3NO5
InChIKeyMRPGRAKIAJJGMM-OCCSQVGLSA-N
CAS Registry1000023-04-0
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acute Myeloid LeukemiaPhase 1
US
31 May 2018
Diffuse Large B-Cell LymphomaPhase 1
US
31 May 2018
Follicular LymphomaPhase 1
US
31 May 2018
Mantle-Cell LymphomaPhase 1
US
31 May 2018
Small Lymphocytic LymphomaPhase 1
US
31 May 2018
Chronic Lymphocytic LeukemiaPhase 1
US
01 Jun 2014
MelanomaPhase 1
US
01 Aug 2013
Hematologic NeoplasmsPhase 1
IN
01 Dec 2008
NeoplasmsPhase 1
CA
01 Dec 2008
Solid tumorPhase 1
IN
01 Dec 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
41
pewpfrhnzc(mluxvtublx) = 22%/2% yhqpjoytlw (mcjsuukzxk )
Positive
08 Dec 2024
Phase 1
40
ausknndtgd(rewlxdegpl) = downregulation of MYC transcriptional program and oxidative phosphorylation in circulating AML blasts, both evident 24 hours after start of voruciclib and ongoing at C1D15 pdgrjqhqtd (txuzhkivlb )
-
11 Dec 2023
Phase 1
29
(lzzxsucfny) = vdxijyslvg nqjwpnfhhv (tdljbprank )
-
20 May 2012
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Core Patent

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Clinical Trial

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Approval

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Regulation

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