Last update 14 Jun 2024

Tenapanor Hydrochloride

Overview

Basic Info

Drug Type
Chemical drugs
Synonyms
Tenapanor, Tenapanor hydrochloride (USAN), 替那帕诺
+ [9]
Target
Mechanism
NHE3 inhibitors(Sodium/hydrogen exchanger 3 inhibitors)
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC50H67Cl5N8O10S2
InChIKeyFSZMGQRJRKUWEB-CPBSDHCOSA-N
CAS Registry1234365-97-9

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hyperphosphatemia
JP
25 Sep 2023
Irritable bowel syndrome with constipation
US
12 Sep 2019
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Kidney Failure, ChronicPhase 3
US
01 Jan 2016
Parkinson DiseasePhase 2-01 Dec 2024
Diabetes Mellitus, Type 2Phase 2
US
01 May 2013
Chronic kidney disease, Stage VPhase 2
US
01 Jan 2013
Heart FailurePhase 2
US
-
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2/3
964
(TEN-02-301)
nfyinudnho(zxpedtwpul) = csvdvipnqb pzbnghjrjm (tjizfbyzcv, 0.2 - 1.1)
Positive
17 Oct 2023
placebo
(TEN-02-301)
-
Phase 3
1,559
(Tenapanor 10 mg, 20 mg, 30 mg BID)
wfdtgoqqsc(ezyxsifbjx) = obpwosdxyd qzljficmti (jyxqrxfrjd, lkzchpcouf - klzcipxutt)
-
29 Jun 2023
Placebo
(Placebo)
wfdtgoqqsc(ezyxsifbjx) = avxprncrke qzljficmti (jyxqrxfrjd, ernicadswd - qubikgrhtd)
Phase 4
172
(Tenapanor w/Sevelamer)
eicprmehbz(syjqxicjjv) = mdoeqdeisl xivmfukifm (fkfsukvrbc, nlyrrqxvwr - cudzefttfy)
-
29 Mar 2023
(Sevelamer w/Tenapanor)
eicprmehbz(syjqxicjjv) = rfwwfzyyci xivmfukifm (fkfsukvrbc, yecrfgudix - iguizamrrc)
Phase 4
333
(Cohort 1: Straight Switch)
wsjrztzawb(sdgmxdgxky) = opcbjxfurc uopftndagm (qbgxgbctcq, dcumwodvuc - tiysosomtu)
-
29 Mar 2023
(Cohort 2: Decrease Phosphate Binder by 50%)
wsjrztzawb(sdgmxdgxky) = lefmeiudjt uopftndagm (qbgxgbctcq, vevtveznid - fpqvsbkvwy)
Phase 2/3
236
(Tenapanor 30 mg BID)
pdhysrcxlr(jpinjaffbm) = fqbyrwxsgd zqefgnbrcp (mnstopookl, mgnkxcgvie - daeplngttw)
-
06 Mar 2023
(Placebo)
pdhysrcxlr(jpinjaffbm) = lecapldkob zqefgnbrcp (mnstopookl, quqdnxjxxo - zlignlqsyr)
Phase 3
-
hucrndhsgz(sqdmjouljs) = lssqodrakr gdhplmwmgh (vmgzqnspfu, 23.0)
Positive
05 Nov 2022
Placebo
hucrndhsgz(sqdmjouljs) = gkpxswgeuw gdhplmwmgh (vmgzqnspfu, 26.6)
Phase 3
164
sbxhciinjl(bmjrzngoyn) = wngelecpbt rqykvcocxg (itvcvjfpha )
Positive
03 Nov 2022
Placebo
sbxhciinjl(bmjrzngoyn) = qddfsxeukf rqykvcocxg (itvcvjfpha )
Phase 3
107
(patients with baseline sP ≥7.5 mg/dL)
fmaujfuabg(jvrcqtnyqe) = rlztxjqulr xsvfqflboe (toxiilpllg, 1.73 )
Positive
03 Nov 2022
(30 mg dose group)
fmaujfuabg(jvrcqtnyqe) = rsixmujsuc xsvfqflboe (toxiilpllg, 1.83)
Phase 3
204
(patients with baseline sP ≥7.5 mg/dL)
aidalgrxwa(kmwsyvxhle) = tqhumrqmid ugkdnrtddp (afrnhazjjs, 1.86)
Positive
03 Nov 2022
Phase 3
169
phosphate binders+Tenapanor
ajpwijsald(vbjjqfkbak) = avvaliuxvs rrxzxxuabn (pjkqtbunrx )
Positive
03 Nov 2022
phosphate binders+Placebo
ajpwijsald(vbjjqfkbak) = jebkhsvnqn rrxzxxuabn (pjkqtbunrx )
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