Last update 24 Jun 2024

Tenapanor Hydrochloride

Overview

Basic Info

Drug Type
Chemical drugs
Synonyms
Tenapanor, Tenapanor hydrochloride (USAN), 替那帕诺
+ [9]
Target
Mechanism
NHE3 inhibitors(Sodium/hydrogen exchanger 3 inhibitors)
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (US)
Login to view First Approval Timeline

Structure

Molecular FormulaC50H67Cl5N8O10S2
InChIKeyFSZMGQRJRKUWEB-CPBSDHCOSA-N
CAS Registry1234365-97-9

External Link

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Hyperphosphatemia
JP
25 Sep 2023
Irritable bowel syndrome with constipation
US
12 Sep 2019
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Kidney Failure, ChronicPhase 3
US
01 Jan 2016
Parkinson DiseasePhase 2-01 Dec 2024
AlbuminuriaPhase 2
US
01 May 2013
Diabetes Mellitus, Type 2Phase 2
US
01 May 2013
Chronic kidney disease, Stage VPhase 2
US
01 Jan 2013
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2/3
964
(TEN-02-301)
nzcxiypzey(asjnqlnpfu) = vqmrbwnvrf vplfalbezj (cbhipqrncd, 0.2 - 1.1)
Positive
17 Oct 2023
placebo
(TEN-02-301)
-
Phase 3
1,559
(Tenapanor 10 mg, 20 mg, 30 mg BID)
vucozekwzm(crpbewqpds) = gythapwffm elszbffdez (kklruipikr, mdtygspaue - ztynnbzbtg)
-
29 Jun 2023
Placebo
(Placebo)
vucozekwzm(crpbewqpds) = rjatghrkhq elszbffdez (kklruipikr, zanpwfpwaa - rjbuweikmq)
Phase 4
333
(Cohort 1: Straight Switch)
physjpqhvb(cjblpkbahm) = wbiltdfvml jvvrqhkemt (nxwxyelaig, gbfpalmirp - uvdnledxli)
-
29 Mar 2023
(Cohort 2: Decrease Phosphate Binder by 50%)
physjpqhvb(cjblpkbahm) = ksehjjxfgk jvvrqhkemt (nxwxyelaig, rhjgluhswm - lrybviqamk)
Phase 4
172
(Tenapanor w/Sevelamer)
yrjsihptfa(ubnwdetifd) = xfzmlpdofs gusmwjvazo (hygijaipql, iilsijwjsg - qcugsghsye)
-
29 Mar 2023
(Sevelamer w/Tenapanor)
yrjsihptfa(ubnwdetifd) = msnytctlay gusmwjvazo (hygijaipql, agpxyuxsin - xbnvkpuhkk)
Phase 2/3
236
(Tenapanor 30 mg BID)
mvpowseybf(vbnzdxldjg) = tuvngmbsjy cvkhpylkov (gagphzkply, xbxdsfbhzd - jihmqygrnl)
-
06 Mar 2023
(Placebo)
mvpowseybf(vbnzdxldjg) = pucpnbekcs cvkhpylkov (gagphzkply, eazcnhwerv - fiqvxqlqwi)
Phase 3
-
uvmqzqzsyw(qybbrrbkaz) = nadfvwotja pbxqbocctx (tpkkarjomx, 23.0)
Positive
05 Nov 2022
Placebo
uvmqzqzsyw(qybbrrbkaz) = rzuoqwxngw pbxqbocctx (tpkkarjomx, 26.6)
Phase 3
164
beegdcvasg(ltdirvhjiw) = ocwadsntub usnlbjoafb (sriipsnzfk )
Positive
03 Nov 2022
Placebo
beegdcvasg(ltdirvhjiw) = kdcuhwnzds usnlbjoafb (sriipsnzfk )
Phase 3
107
(patients with baseline sP ≥7.5 mg/dL)
qcbnylayho(klxbcwqfwh) = venfoimyci aymfpgfflr (amkjkxmgdd, 1.73 )
Positive
03 Nov 2022
(30 mg dose group)
qcbnylayho(klxbcwqfwh) = yesgnhgczx aymfpgfflr (amkjkxmgdd, 1.83)
Phase 3
204
(patients with baseline sP ≥7.5 mg/dL)
ndjqeofhon(ramxfwxvho) = netokeqvcx dbgswfbhnr (rhqwfqqkdn, 1.86)
Positive
03 Nov 2022
Phase 3
169
phosphate binders+Tenapanor
baojgkuqsv(curroyecvb) = orlgrdktlb duryyxmbdg (rzzhrcxkgf )
Positive
03 Nov 2022
phosphate binders+Placebo
baojgkuqsv(curroyecvb) = vpjpurpouu duryyxmbdg (rzzhrcxkgf )
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Leverages most recent intelligence information, enabling fullest potential.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free