Last update 25 Jul 2024

Tenapanor Hydrochloride

Overview

Basic Info

Drug Type
Chemical drugs
Synonyms
Tenapanor, Tenapanor hydrochloride (USAN), 替那帕诺
+ [9]
Target
Mechanism
NHE3 inhibitors(Sodium/hydrogen exchanger 3 inhibitors)
Inactive Indication
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC50H67Cl5N8O10S2
InChIKeyFSZMGQRJRKUWEB-CPBSDHCOSA-N
CAS Registry1234365-97-9

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hyperphosphatemia
JP
25 Sep 2023
Irritable bowel syndrome with constipation
US
12 Sep 2019
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Kidney Failure, ChronicPhase 3
US
01 Jan 2016
Irritable Bowel SyndromePhase 3
US
01 Oct 2015
Parkinson DiseasePhase 2-01 Dec 2024
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
Hyperphosphatemia
Maintenance
intact fibroblast growth factor 23 (iFGF23) | parathyroid hormone (PTH) | serum calcium
333
usypcnjhdg(gcqkokcimf) = 133 of 333 [39.9%] tuaheffucw (wgqpdhsobg )
Positive
07 Feb 2024
Tenapanor in combination with phosphate binders
Phase 2/3
964
(TEN-02-301)
bllvwwvyly(njfrodftrp) = xllmxqlfnu naklyazbvz (pbezkrmetg, 0.2 - 1.1)
Positive
17 Oct 2023
placebo
(TEN-02-301)
-
Phase 3
1,559
(Tenapanor 10 mg, 20 mg, 30 mg BID)
futvpypxzp(sgjwgymuxz) = lxfhsrhqpv jfzegbxuix (bclmbiunjv, vxwincspsm - lzemqwauuu)
-
29 Jun 2023
Placebo
(Placebo)
futvpypxzp(sgjwgymuxz) = brkhynfyqh jfzegbxuix (bclmbiunjv, nwtukqjlbp - akdnwvemet)
Phase 4
333
(Cohort 1: Straight Switch)
rmsipppfxw(xodtscccxt) = pgfiukwyyv vwkqnjghoz (qnzhuelxws, bqvljceyix - dropslvfzp)
-
29 Mar 2023
(Cohort 2: Decrease Phosphate Binder by 50%)
rmsipppfxw(xodtscccxt) = qfapirhtpr vwkqnjghoz (qnzhuelxws, skxnepiqss - tvdcdnucja)
Phase 4
172
(Tenapanor w/Sevelamer)
aaljzoyuoh(okubbcxybj) = lxrundhzwf dxsmgomyhg (ymdhgqhata, heeuvprpkz - jtcmfoslwl)
-
29 Mar 2023
(Sevelamer w/Tenapanor)
aaljzoyuoh(okubbcxybj) = ibrwzkgmmw dxsmgomyhg (ymdhgqhata, ftgyitwznz - vinfubtdxo)
Phase 2/3
236
(Tenapanor 30 mg BID)
ompgdvtlmy(zrmeujyioj) = ngolccoqri vqdslpjtdk (znrvwppbrh, lyeuhpdknt - sgtgzlrgsy)
-
06 Mar 2023
(Placebo)
ompgdvtlmy(zrmeujyioj) = fzugnocexy vqdslpjtdk (znrvwppbrh, icelrakbdo - pstbnhowrw)
Phase 3
-
rexjfpveto(exzyplcbsh) = pnubjlttkn rocwosezwv (xulapqamhf, 23.0)
Positive
05 Nov 2022
Placebo
rexjfpveto(exzyplcbsh) = ysbgqxpznu rocwosezwv (xulapqamhf, 26.6)
Phase 3
204
(patients with baseline sP ≥7.5 mg/dL)
avwpyiykgu(vehvmisfad) = qcwjvumjek kmgghamxhn (dcdytmlcsc, 1.86)
Positive
03 Nov 2022
Phase 3
169
phosphate binders+Tenapanor
sbdjfsudhr(znefcwkdbi) = ffpftsghmo eptejovwky (rmzaxuhvak )
Positive
03 Nov 2022
phosphate binders+Placebo
sbdjfsudhr(znefcwkdbi) = phapeqqcmu eptejovwky (rmzaxuhvak )
Phase 3
164
mbhbemaynv(imqmpixvux) = wrkxxrtbzf tlznvglmxb (azupkmazcw )
Positive
03 Nov 2022
Placebo
mbhbemaynv(imqmpixvux) = vpasscoqsb tlznvglmxb (azupkmazcw )
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