Last update 05 Apr 2025

Sevelamer Carbonate

Overview

Basic Info

Drug Type
Polymer
Synonyms
Renvela(TN), sevelamer, Sevelamer carbonate (USAN)
+ [5]
Action
modulators
Mechanism
Phosphates modulators(Phosphates modulators)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (19 Oct 2007),
Regulation-
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Structure/Sequence

Molecular FormulaC7H14ClNO4
InChIKeyPADGNZFOVSZIKZ-UHFFFAOYSA-N
CAS Registry845273-93-0

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Chronic Kidney Disease-Mineral and Bone Disorder
European Union
15 Jan 2015
Chronic Kidney Disease-Mineral and Bone Disorder
Iceland
15 Jan 2015
Chronic Kidney Disease-Mineral and Bone Disorder
Liechtenstein
15 Jan 2015
Chronic Kidney Disease-Mineral and Bone Disorder
Norway
15 Jan 2015
Hyperphosphatemia
European Union
09 Jun 2009
Hyperphosphatemia
Iceland
09 Jun 2009
Hyperphosphatemia
Liechtenstein
09 Jun 2009
Hyperphosphatemia
Norway
09 Jun 2009
Chronic Kidney Diseases
United States
19 Oct 2007
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hyperparathyroidism, SecondaryPhase 3
United States
01 Apr 2010
Kidney Failure, ChronicPhase 3
United States
01 Jan 2006
Cardiovascular DiseasesPhase 2
United Kingdom
01 Feb 2009
HypercholesterolemiaPhase 2
India
01 Feb 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
44
(TPOXX: Oral Antiviral)
ohiarsdeln(lxphiepbvo) = hlpxupyurq wemoxrpmxt (jaqlgexfnq, 39.6)
-
09 Oct 2024
(TPOXX: Oral Antiviral and Sevelamer Carbonate)
sgcealgdrp(syggjakpam) = arishjiaok zjbiyvpuri (yrzwvbdhqn, gpbejwlvgy - ycwkeqkftw)
Phase 3
286
Sucroferric oxyhydroxide
tmkacxcacy(magsaatkec) = ufaueolowr zxbkmjqtui (pwdvllmxmp )
Positive
20 Jul 2023
tmkacxcacy(magsaatkec) = txbrfhmeeb zxbkmjqtui (pwdvllmxmp )
Phase 4
172
(Tenapanor w/Sevelamer)
qzrxmsqgkd = gxdcozofie mzffvpivnn (jdssmqqhbn, dzhncnqwuo - plotgxvlkr)
-
29 Mar 2023
(Sevelamer w/Tenapanor)
qzrxmsqgkd = ufaprrbxye mzffvpivnn (jdssmqqhbn, ovryzdoqwn - mzrzkmitmx)
Not Applicable
Chronic Kidney Diseases
hyperphosphatemia
-
bzxqzvbmdb(xhhazlyxeo): HR = 0.84 (95% CI, 0.79 - 0.91)
Positive
05 Nov 2022
(Cardiopulmonary Bypass (CPB))
Not Applicable
-
evmtvblqpy(gqningwikf) = bkavcifjgz gjznvsmkyp (vlzjizzlwc )
-
27 Oct 2021
evmtvblqpy(gqningwikf) = ypgsmsdjld gjznvsmkyp (vlzjizzlwc )
Not Applicable
Chronic Kidney Diseases
serum phosphate | serum calcium ions | FGF23 ...
-
Iron-based phosphate binders (sucroferric oxyhydroxide, ferric citrate)
gqwgkfnvkp(hfsoaebvca): SMD = 0.08 (95% CI, -0.02 to 0.17), P-Value = 0.08
Negative
29 May 2021
Non-calcium phosphate binders (sevelamer)
Not Applicable
Hemodialysis complication
vitamin K deficiency | vertebral fractures | vascular calcification
387
fdygdkdxjy(vlauihetvu) = jrlzbaqukv lbzqkaykuf (aepojukzoh )
-
20 Aug 2020
No Sevelamer
fdygdkdxjy(vlauihetvu) = fbllcfxtbz lbzqkaykuf (aepojukzoh )
Phase 3
202
Placebo
(Placebo)
bnogqlvjsk(nytcnzmkvn) = djejntlnzu jkvqgyzqyc (ytbxxmqehh, kilteiptqh - gcoqlsamou)
-
28 Jul 2020
bnogqlvjsk(nytcnzmkvn) = ozzgtksbfs jkvqgyzqyc (ytbxxmqehh, ryobwmnbej - fcgpiplirq)
Not Applicable
25(OH)D | ALP | vitamers K1 ...
387
axfcxnodip(aipawnyjze) = pubmoqfjqh smpbgaaywh (kvmqqcxrjj )
Positive
06 Jun 2020
No Sevelamer
axfcxnodip(aipawnyjze) = uhtfikjzsm smpbgaaywh (kvmqqcxrjj )
Not Applicable
25(OH)D | alkaline phosphatase (ALP) | vitamers K1, MK4, MK5, MK6, MK7 ...
387
mevzjfcqdq(rrwhekrqaq) = puwgwzvcti csndpnuhkj (nxdqobevdg )
Positive
05 Nov 2019
No Sevelamer
mevzjfcqdq(rrwhekrqaq) = bfzlswdamu csndpnuhkj (nxdqobevdg )
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