Last update 01 Sep 2025

Sevelamer Carbonate

Overview

Basic Info

Drug Type
Polymer
Synonyms
Renvela(TN), sevelamer, Sevelamer carbonate (USAN)
+ [7]
Action
modulators
Mechanism
Phosphates modulators(Phosphates modulators)
Originator Organization
License Organization
Drug Highest PhaseApproved
First Approval Date
United States (19 Oct 2007),
Regulation-
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Structure/Sequence

Molecular FormulaC7H14ClNO4
InChIKeyPADGNZFOVSZIKZ-UHFFFAOYSA-N
CAS Registry845273-93-0

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Chronic Kidney Disease-Mineral and Bone Disorder
European Union
15 Jan 2015
Chronic Kidney Disease-Mineral and Bone Disorder
Iceland
15 Jan 2015
Chronic Kidney Disease-Mineral and Bone Disorder
Liechtenstein
15 Jan 2015
Chronic Kidney Disease-Mineral and Bone Disorder
Norway
15 Jan 2015
Hyperphosphatemia
European Union
09 Jun 2009
Hyperphosphatemia
Iceland
09 Jun 2009
Hyperphosphatemia
Liechtenstein
09 Jun 2009
Hyperphosphatemia
Norway
09 Jun 2009
Chronic Kidney Diseases
United States
19 Oct 2007
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Kidney Failure, ChronicPhase 3
France
01 Oct 2010
Hyperparathyroidism, SecondaryPhase 3
United States
01 Apr 2010
Cardiovascular DiseasesPhase 2
United Kingdom
01 Feb 2009
Diabetes Mellitus, Type 2Clinical
Denmark
01 Feb 2014
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
44
(TPOXX: Oral Antiviral)
kbpgoikkxc(jeeiowflql) = lryevqlfbf jdjwbytgvt (wpdxwwymwn, 39.6)
-
09 Oct 2024
(TPOXX: Oral Antiviral and Sevelamer Carbonate)
bioyfrhhhh(rshtdrlref) = mvqunrowyw ikniehhdvl (bxyunsoxor, qpxybtppeo - fuotkuyqbv)
Phase 3
286
buxouwewbs(luoqqaamer) = sbitcktdfn xlusrxjreu (fyqumabpcz )
Positive
20 Jul 2023
buxouwewbs(luoqqaamer) = yxqxszpttv xlusrxjreu (fyqumabpcz )
Phase 4
172
(Tenapanor w/Sevelamer)
qpwfvpkmgg = abmijnyzjn rxvxjyelkd (exttmqhfcc, bxwhlmvrjk - ljtojkmlbw)
-
29 Mar 2023
(Sevelamer w/Tenapanor)
qpwfvpkmgg = qwgndunpph rxvxjyelkd (exttmqhfcc, cozaivgzqa - ayxtyhzhjf)
Not Applicable
Chronic Kidney Diseases
hyperphosphatemia
-
hcegjvpjhk(yjnejtaftx): HR = 0.84 (95% CI, 0.79 - 0.91)
Positive
05 Nov 2022
(Cardiopulmonary Bypass (CPB))
Phase 3
202
Placebo
(Placebo)
prvircnxgx(lisnpuraox) = xggjkptwbo oxndcnecfk (wqpujiuszc, gqdioeqnkm - dgfpeqvifr)
-
28 Jul 2020
prvircnxgx(lisnpuraox) = yuwjuwgbvx oxndcnecfk (wqpujiuszc, gtqqqifgum - osryigfjoh)
Phase 2
66
hyllybdxwz(zuieaclrdq): difference = -0.90, P-Value = 0.001
Positive
01 Feb 2018
Placebo
Phase 3
96
hctowlcpjb(rkakxdadvg) = fdzmmxvdsj wqzhtfdjlx (xwiuaregrw )
Negative
07 Dec 2017
Placebo
hctowlcpjb(rkakxdadvg) = ivpgbdivpf wqzhtfdjlx (xwiuaregrw )
Not Applicable
24
rryffagfxn(vgfhfwpexh) = zjiilxskuf eayofxbtgf (nxpbqgulof, qsaesylpwi - bpvorfyamc)
-
21 Jun 2017
Not Applicable
18
xjdbwhwjdi(ytbfvaxasf) = hamspyxkhz buvtocrugd (fhyfcgdoit, 41)
-
31 Mar 2017
Placebo
(Placebo)
xjdbwhwjdi(ytbfvaxasf) = rzmileopwq buvtocrugd (fhyfcgdoit, 46)
Phase 2
101
mapklbeagu(mdiyppxpwt) = gvmftospxn vpyfdmnotl (dfwjojivlb )
Positive
15 Nov 2016
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Approval

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Regulation

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