Bewintinib

Primary purpose: To evaluate the efficacy of Bonretinib tablets in the treatment of PV subjects with HU resistance/intolerance. Secondary purpose: To evaluate the sustainability of the efficacy of Bonretinib tablets in the treatment of PV subjects with HU resistance/intolerance; To evaluate the safety of Bonretinib tablets in the treatment of PV subjects with HU resistance/intolerance.

Main study objectives: 1 To quantitatively analyze the total radioactivity in excreta after oral administration of [14C]bangretinib to healthy male subjects, and obtain the cumulative excretion rate and main excretion pathway of human radioactivity; 2 To investigate the distribution of [14C]bangretinib in whole blood and plasma and the pharmacokinetics of total radioactivity in plasma after a single oral administration of [14C]bangretinib to healthy male subjects; 3 To identify the main metabolites in plasma, urine and feces after oral administration of [14C]bangretinib to healthy male subjects, and determine the main biotransformation pathways and main metabolites (close to or greater than 10% of the total radioactivity AUC); 4 To quantitatively analyze the concentration of bangretinib and its main metabolites (if applicable) in plasma using a validated LC-MS/MS method, and obtain the pharmacokinetic parameters of bangretinib and its main metabolites (if applicable) in plasma. Secondary study objectives: To observe the safety of healthy male subjects after a single dose of [14C]bangretinib.