Drug Type Small molecule drug |
Synonyms Filanesib (USAN/INN), Filanesib-hydrochloride, ARRY-520 |
Target |
Mechanism KIF11 inhibitors(Kinesin-like protein 1 inhibitors) |
Therapeutic Areas |
Active Indication- |
Inactive Indication |
Originator Organization |
Active Organization- |
Inactive Organization |
Drug Highest PhaseDiscontinuedPhase 3 |
First Approval Date- |
RegulationOrphan Drug (US) |
Molecular FormulaC20H22F2N4O2S |
InChIKeyLLXISKGBWFTGEI-FQEVSTJZSA-N |
CAS Registry885060-09-3 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Multiple Myeloma | Phase 3 | AT | - | |
Multiple Myeloma | Phase 3 | BE | - | |
Multiple Myeloma | Phase 3 | CZ | - | |
Multiple Myeloma | Phase 3 | DE | - | |
Multiple Myeloma | Phase 3 | GR | - | |
Multiple Myeloma | Phase 3 | HU | - | |
Multiple Myeloma | Phase 3 | ES | - | |
Multiple Myeloma | Phase 3 | SE | - | |
Multiple Myeloma | Phase 3 | GB | - | |
Plasma cell myeloma refractory | Phase 2 | US | 01 May 2014 |
NCT01372540 (Pubmed) Manual | Phase 1 | Relapse multiple myeloma Second line | 63 | (Part A) | ywqktbpvgf(fzntgypnnu) = Among 30 patients treated at the MTD for the Part A dose-expansion cohorts with filanesib 1.5 mg/m2, carfilzomib 20/27 mg/m2, and dexamethasone 4 mg,A total of 14 patients were treated at the MTD for the Part B dose-expansion cohort with filanesib 1.5 mg/m2, carfilzomib 20/56 mg/m2, and dexamethasone (4 mg prior to each carfilzomib dose in 10 patients and 40 mg on days 1, 8, and 15 in 4 patients due to protocol amendment) umbbahqjtg (wevsemoudd ) View more | Positive | 01 Oct 2019 |
(Part B) | |||||||
NCT00821249 (Pubmed) Manual | Phase 1/2 | - | asmyayebtv(daluhoxwzy) = qjwkzjgnjm qmhxfrufux (dnnrifrtsx ) View more | Positive | 01 Dec 2017 | ||
- | |||||||
Phase 2 | 247 | (Patients with low AAG) | fbzdkasyqh(wdbkbismgh) = gnoinyrjvk fzladptsau (dbvqzvphfw ) | - | 21 May 2015 | ||
(Patients with high AAG) | fbzdkasyqh(wdbkbismgh) = khmpgalide fzladptsau (dbvqzvphfw ) | ||||||
Phase 1 | 41 | (Initial Schedules) | oaahxdyqmd(hooslmphkb) = pjwelclbrx xbghdbcgcz (zklkutwhla ) | Positive | 01 Apr 2015 | ||
(Alternate Schedules) | oaahxdyqmd(hooslmphkb) = mqxbcaqpma xbghdbcgcz (zklkutwhla ) | ||||||
Phase 1 | Refractory Leukemia KSP inhibition | 36 | pzrmjtzsrw(zxudlranse) = slhzkrpqms ypalqeirdu (bscgdwdwjj ) | Negative | 15 Jul 2012 | ||
Phase 1 | 34 | dovxeakvwk(gedakltvjc) = awsmprqzii uxyhtqgxey (pidlfipxwz ) View more | - | 20 May 2010 | |||
Phase 1 | 15 | pmlsrkzjtn(dplrnblagr) = wgzapdjxmw nwfeaiyfmr (chtkvrbqtd ) | - | 20 May 2009 |