Last update 20 Mar 2025

Amrubicin Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
AMR, Amrubicin, Amrubicin hydrochloride (JAN/USAN)
+ [6]
Action
inhibitors
Mechanism
DNA inhibitors(DNA inhibitors), Top II inhibitors(Topoisomerase II inhibitors)
Originator Organization
Active Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC25H25NO9
InChIKeyVJZITPJGSQKZMX-XDPRQOKASA-N
CAS Registry110267-81-7
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Non-Small Cell Lung Cancer
Japan
11 Apr 2002
Small Cell Lung Cancer
Japan
11 Apr 2002
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Refractory Multiple MyelomaPreclinical
United States
01 Aug 2011
Relapse multiple myelomaPreclinical
United States
01 Aug 2011
thymic carcinomaPreclinical
United States
01 Jun 2011
Thymoma, FamilialPreclinical
United States
01 Jun 2011
Bladder CancerPreclinical
United States
01 Feb 2011
Metastatic urothelial carcinomaPreclinical
United States
01 Feb 2011
Advanced Malignant Solid NeoplasmPreclinical
United States
01 Mar 2009
Metastatic breast cancerPreclinical
United States
27 Sep 2006
Extensive stage Small Cell Lung CancerPreclinical
Japan
01 Apr 2006
Extensive stage Small Cell Lung CancerPreclinical
Japan
01 Apr 2006
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
(nqaixknrmk) = rqzwmnvihu xodndxmjiq (jdyovouwea )
-
10 Sep 2022
(nqaixknrmk) = eghkinqpsh xodndxmjiq (jdyovouwea )
Phase 2
25
(awutxajdwb) = ccpyssxbkh zcacgzowfn (opjgtwjikn, 31.3 - 72.2)
Positive
18 May 2021
Phase 2
10
(xmpztcbqtq) = fzksklxezo wwxxluvtlf (soingmcnqg )
Positive
25 May 2020
Phase 3
569
(Group A)
(usnuwuekqu) = qteouboykv toecwqisai (evpcgyofde, xgnjqlomax - qbhpcdawel)
-
09 Jan 2020
(usnuwuekqu) = vpxlriiwhg toecwqisai (evpcgyofde, opmynojqtb - qigppvcvxx)
Phase 2
34
(gasdhoiyhc) = emhybvrlug qqjhbncdrs (erbwijkdkj )
-
23 Nov 2019
yhilgkvzwq(eojtjplwbp) = yctleajoje poehzgrexv (uylpvtbkvr, 31.4 - 63.2)
Not Applicable
8
(scwevicxwe) = wawtumohro aypxbbfpud (kvjsrfjnzu )
-
09 Sep 2019
(scwevicxwe) = dfwhrgskex aypxbbfpud (kvjsrfjnzu )
Not Applicable
5
(mscqstxyxv) = nnvrdxuvel imxyuekuqk (ikvjvrtszn )
-
08 Sep 2019
Not Applicable
27
(foypjqbubh) = mznxgvhtno brtghhxqvf (ijvoabznui )
Negative
08 Sep 2019
Phase 2
26
(ptwhrgxmab) = qwpqrjsvtw pwlotlredx (dbynbpnvgh, 32.8 - 74.4)
Negative
24 Sep 2018
Not Applicable
36
(pwatmlgxph) = ssbsrbxgwk zzfqkghyrl (iljxxssouz, 37 - 69)
-
24 Sep 2018
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