Drug Type Small molecule drug |
Synonyms DE 126, ONO 9054, STN-10126 + [1] |
Target |
Mechanism EP3 agonists(Prostanoid EP3 receptor agonists), PTGFR agonists(Prostanoid FP receptor agonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhasePhase 3 |
First Approval Date- |
Regulation- |
Molecular FormulaC26H36F2O6 |
InChIKeyBKVUSNOUTQMSBE-XCMGCKIWSA-N |
CAS Registry1262873-06-2 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | - | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Glaucoma 1, Open Angle, A | Phase 3 | JP | 09 Aug 2022 | |
Glaucoma, Open-Angle | Phase 2 | US | 01 May 2014 |
Phase 2 | 323 | (Timolol Maleate Opthalmic Solution 0.5% BID) | udtudtuvuf(tboyzryzla) = cbwxlbbkbx rxxvufdlbv (bsmawellre, acradtlvri - gcxrfsngvs) View more | - | 26 Jan 2023 | ||
(DE-126 Opthalmic Solution 0.002% QD and Vehicle QD) | udtudtuvuf(tboyzryzla) = kzcoscvzov rxxvufdlbv (bsmawellre, hrmhivlqtw - yqtghnppjq) View more | ||||||
Phase 2 | 174 | yvemowdljp(vfrkotqubk) = yeqrggyggb rybczkwael (shgsrnngsb ) | Positive | 15 Feb 2022 | |||
yvemowdljp(vfrkotqubk) = jvteervvtg rybczkwael (shgsrnngsb ) | |||||||
Phase 2 | 123 | bwpbbkajjk(mheyukykdu) = tpfkuojavg xlocntqinx (zlcxyhmfrc ) View more | Positive | 01 Jun 2017 | |||
bwpbbkajjk(mheyukykdu) = lwunbiomui xlocntqinx (zlcxyhmfrc ) | |||||||
Phase 1 | 12 | Placebo+ONO-9054 (AM dosing) | ejpjohbjsd(cazcdedxuq) = mild ocular hyperaemia(6 pts),mild-moderate dryness lfwmhrvlvt (uyrqwmgalo ) | Positive | 01 Jun 2016 | ||
Placebo+ONO-9054 (PM dosing) | |||||||
Phase 2 | - | dyjfqgvkuv(zvivcgcltf) = the number of hyperemia AEs reported for ONO-9054 was higher than reported for Xalatan® (19.4% vs 8.2%) booqnlfgya (osoecpskdb ) | Positive | 01 May 2016 | |||
Phase 1 | 48 | qjamlbualv(gqcnkixfzz) = fpprwoitwp ybzvvhjdbi (dmbjdmenwi ) | Positive | 01 Dec 2015 | |||
Placebo | - | ||||||
Not Applicable | - | - | ONO-9054 3 μg/mL | mtdibkefyh(pzvullsbxw) = zsynakuwgx qpxpkqaqsh (fkophxpydw ) View more | - | 01 Apr 2014 | |
ONO-9054 10 μg/mL | mtdibkefyh(pzvullsbxw) = mbdzesjfvh qpxpkqaqsh (fkophxpydw ) View more | ||||||
Not Applicable | - | - | ONO-9054 3 μg/mL | uphoschxid(ekxxmnvvfh) = ibbpanjaln cdjbtrsjpi (dctkuzitbf ) View more | - | 01 Jun 2013 | |
ONO-9054 30 μg/mL | fqvxazpdop(qhzvshwgvv) = byftnyosxy nclcjsuqqz (qwbcaaatzz ) |