Last update 14 Nov 2024

Sepetaprost

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
DE 126, ONO 9054, STN-10126
+ [1]
Mechanism
EP3 agonists(Prostanoid EP3 receptor agonists), PTGFR agonists(Prostanoid FP receptor agonists)
Therapeutic Areas
Active Indication
Inactive Indication-
Originator Organization
Drug Highest PhasePhase 3
First Approval Date-
Regulation-
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Structure

Molecular FormulaC26H36F2O6
InChIKeyBKVUSNOUTQMSBE-XCMGCKIWSA-N
CAS Registry1262873-06-2

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Glaucoma 1, Open Angle, APhase 3
JP
09 Aug 2022
Glaucoma, Open-AnglePhase 2
US
01 May 2014
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
323
(Timolol Maleate Opthalmic Solution 0.5% BID)
udtudtuvuf(tboyzryzla) = cbwxlbbkbx rxxvufdlbv (bsmawellre, acradtlvri - gcxrfsngvs)
-
26 Jan 2023
(DE-126 Opthalmic Solution 0.002% QD and Vehicle QD)
udtudtuvuf(tboyzryzla) = kzcoscvzov rxxvufdlbv (bsmawellre, hrmhivlqtw - yqtghnppjq)
Phase 2
174
yvemowdljp(vfrkotqubk) = yeqrggyggb rybczkwael (shgsrnngsb )
Positive
15 Feb 2022
yvemowdljp(vfrkotqubk) = jvteervvtg rybczkwael (shgsrnngsb )
Phase 2
123
bwpbbkajjk(mheyukykdu) = tpfkuojavg xlocntqinx (zlcxyhmfrc )
Positive
01 Jun 2017
bwpbbkajjk(mheyukykdu) = lwunbiomui xlocntqinx (zlcxyhmfrc )
Phase 1
12
Placebo+ONO-9054
(AM dosing)
ejpjohbjsd(cazcdedxuq) = mild ocular hyperaemia(6 pts),mild-moderate dryness lfwmhrvlvt (uyrqwmgalo )
Positive
01 Jun 2016
Placebo+ONO-9054
(PM dosing)
Phase 2
-
dyjfqgvkuv(zvivcgcltf) = the number of hyperemia AEs reported for ONO-9054 was higher than reported for Xalatan® (19.4% vs 8.2%) booqnlfgya (osoecpskdb )
Positive
01 May 2016
Phase 1
48
qjamlbualv(gqcnkixfzz) = fpprwoitwp ybzvvhjdbi (dmbjdmenwi )
Positive
01 Dec 2015
Placebo
-
Not Applicable
-
-
ONO-9054 3 μg/mL
mtdibkefyh(pzvullsbxw) = zsynakuwgx qpxpkqaqsh (fkophxpydw )
-
01 Apr 2014
ONO-9054 10 μg/mL
mtdibkefyh(pzvullsbxw) = mbdzesjfvh qpxpkqaqsh (fkophxpydw )
Not Applicable
-
-
ONO-9054 3 μg/mL
uphoschxid(ekxxmnvvfh) = ibbpanjaln cdjbtrsjpi (dctkuzitbf )
-
01 Jun 2013
ONO-9054 30 μg/mL
fqvxazpdop(qhzvshwgvv) = byftnyosxy nclcjsuqqz (qwbcaaatzz )
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Approval

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Regulation

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