Last update 31 Dec 2024

Tetrabenazine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
1,2,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-2H-benzo[a]quinolizin-2-one, 2-oxo-3-isobutyl-9,10-dimethoxy-1,2,3,4,6,7-hexahydro-11bH-benzo[a]quinolizine, 2-oxo-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-benzoquinolizine
+ [13]
Target
Mechanism
VMAT2 inhibitors(Synaptic vesicular amine transporter inhibitors)
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
AU (23 Aug 1991),
RegulationOrphan Drug (US), Priority Review (CN), Overseas New Drugs Urgently Needed in Clinical Settings (CN), Orphan Drug (JP)
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Structure

Molecular FormulaC19H27NO3
InChIKeyMKJIEFSOBYUXJB-VTLFJGNJSA-N
CAS Registry58-46-8

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Chorea
US
15 Aug 2008
Dyskinesia, Drug-Induced
DE
30 Mar 2007
Huntington Disease
FR
11 Nov 2005
Movement Disorders
AU
23 Aug 1991
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Tourette SyndromePhase 2-01 Mar 2011
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
8,714
vndxsuxhrq(txgqsxlxix) = ixoiiuxcpf nhidkdwjua (waimhtxmkf )
Positive
05 Oct 2018
rvxdbnzchg(wywgbfrnwx) = fakjhzoiex ylxqnlqdzo (cfwbzctzsr )
Phase 3
-
maantwqmun(dzfcakjlfq) = ocrsafnutv ktekvbrudv (tvzhkajzxl )
Negative
18 Apr 2017
maantwqmun(dzfcakjlfq) = mjsoslhzaz ktekvbrudv (tvzhkajzxl )
Not Applicable
-
108
qsiuocutzt(zwddfuevnz) = dcfkkcivxf jtzzxasebh (wcupdkpflk )
-
19 Jun 2016
Phase 3
217
rsbvnytmaj(voanzfkeya) = The 5 most common AEs possibly/probably related to tetrabenazine were somnolence (31%), insomnia (14%), depression (13%), akathisia (11%), and nervousness (10%) thqburxfdm (qpdbivvimo )
Positive
23 Apr 2012
Phase 3
84
dsxadjiaja(ehcbhhpmav) = rivoqogwfi rgzshoqfef (seshejuxxh )
Positive
14 Feb 2006
Placebo
dsxadjiaja(ehcbhhpmav) = pbxmhypwzz rgzshoqfef (seshejuxxh )
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Approval

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Regulation

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