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From hirings and firings to promotions, resignations and surprising shake-ups, these were the most important medtech leadership changes of the year. By Associate Editor Sean Whooley and Managing Editor Jim Hammerand The leadership change at Johnson & Johnson MedTech was a surprising shift that ended up as the year’s biggest medtech leadership change of 2023. In October, J&J EVP and J&J MedTech Worldwide Chair Ashley McEvoy announced her resignation from the world’s second-largest device manufacturer. She’s staying on into the first quarter of 2024 while her successor, Tim Schmid, gets settled into his new role. Schmid, a 30-year J&J vet who was most recently company group chair of J&J MedTech Asia Pacific, said he’s “committed to building even further on the progress we’ve already made.” “While I recognize that we have more work to do, I’m focused on further advancing our impact and our competitiveness,” he said in the final weeks of 2023. “Our goal is clear. It is to be No. 1 or No. 2 in every market that we compete.” Related: Who is Tim Schmid, Johnson & Johnson MedTech’s new leader? Here are more of the top medtech personnel moves of 2023, starting with the world’s largest device manufacturer. Movement in and out of Medtronic There has been plenty of change at Medtronic. Sometime around the beginning of 2023, Medtronic promoted Surgical Robotics President Mike Marinaro to EVP and president of the new Surgical operating unit. Medtronic declined to say when, exactly, the change took effect, as it made the change without a public announcement while consolidating its surgical robotics and more traditional surgical devices into a single operating unit. In the C-suite, Medtronic hired Scott Cundy as chief quality officer . Cundy returned to Medtronic after nearly 13 years at Danaher. Medtronic also created the new role of chief technology and innovation officer and hired Ken Washington to fill it . Formerly chief technology officer at Ford, Washington most recently served as VP and GM of consumer robotics at Amazon. Related: AI basics from Medtronic Chief Technology and Innovation Officer Ken Washington Medtronic also hired Paolo Di Vincenzo as the president of its neuromodulation business. Di Vincenzo joined from Smith+Nephew, where he served as SVP and GM of U.S. advanced wound management. Medtronic departures included EVP and Chief Human Resources Officer Carol Surface, who was recruited by Apple to serve as its first chief people officer. Cardiovascular Diagnostics and Services President Julie Brewer left to become Baxter’s president of patient support systems, global surgical solutions and care communications. And Medtronic Spine & Biologics VP and GM Carlton Weatherby joined Inspire Medical as chief strategy officer. Zimmer Biomet CEO leaves to lead 3M HealthCare spinoff Bryan Hanson resigned as Zimmer Biomet’s president and CEO to become CEO at Solventum, 3M’s soon-to-be-completed healthcare business spinoff. This move set in motion a series of executive changes at both companies and across medtech. Zimmer Biomet promoted Chief Operating Officer Ivan Tornos to president and CEO and made other leadership changes. 3M, meanwhile, hired Insulet CFO Wayde McMillan to lead the spinoff’s financial operations, while 3M HealthCare President Jim Lavers departed to make way for Hanson. Intuitive Surgical’s new president Intuitive Surgical promoted Dave Rosa to president, leading the product, digital, quality, regulatory, supply chain, manufacturing and commercial teams as the surgical robotics developer expands globally. Intuitive also named Bob DeSantis to the new role of EVP and chief strategy and corporate operations officer. Related: Intuitive’s Dave Rosa offers advice for perseverance and surgical robotics Recor Medical switches gears Recor Medical — which became the first renal denervation developer to win FDA approval for treating hypertension — started its monumental year by naming Lara Barghout as its new CEO and president to lead global commercialization. The former Siemens Healthineers and Terumo executive succeeded Andrew Weiss, who as Recor CEO since 2013 led the technology’s development, clinical trials and FDA submission. Related: Recor Medical CEO Lara Barghout on leadership lessons and what she looks for when hiring New CEO at Silk Road Medical Silk Road Medical hired Chas McKhann as CEO to replace retired CEO Erica Rogers. McKhann was formerly CEO of Apollo Endosurgery, which Boston Scientific acquired for $615 million in April. Cordis board chair becomes CEO Former Spectranetics CEO Scott Drake became executive board chair at Cordis and then took over as CEO, replacing Shar Matin when he stepped down as CEO in November. Orthofix picks new CEO after terminating trio of execs After merging with SeaSpine, Orthofix ousted CEO Keith Valentine, CFO John Bostjancic and Chief Legal Officer Patrick Keran, terminating them with cause after an investigation found “repeated inappropriate and offensive conduct.” Orthofix later announced Massimo Calafiore as its new CEO. Calafiore, the former CEO of LimaCorporate, started as Orthofix CEO and president in January 2024 after Enovis completed its acquisition of LimaCorporate. Distalmotion selects former Zimmer Biomet exec as CEO Switzerland-based Distalmotion appointed Greg Roche as its CEO as the company continues commercial expansion of its surgical robot. Roche most recently served as CEO of soft tissue robotics company AvateraMedical, and before that was global president of robotics and technology at Zimmer Biomet. Shockwave Medical hires Abbott exec as CMO Intravascular lithotripsy technology developer Shockwave Medical named Dr. Nick West as its CMO-in-waiting . The former CMO and divisional VP of global medical affairs at Abbott Vascular will take over for Dr. Keith Dawkins in mid-2024. GE HealthCare hires from Baxter and Amazon GE HealthCare hired former Amazon executive Dr. Taha Kass-Hout as its first chief technology officer. GE HealthCare also hired Jay Saccaro as SVP and CFO after a 21-year career at Baxter, most recently as CFO. Baxter hired Sysco vet Joel Grade to replace Saccaro as EVP and CFO. Abbott promotes finance execs Abbott promoted CFO Robert Funck to EVP of finance and named Philip Boudreau as CFO and SVP of finance. Boston Scientific replaces chief medical officer Dr. Ken Stein became Boston Scientific’s chief medical officer, taking over for Dr. Ian Meredith, who retired from the role he held since 2017. Stein joined Boston Scientific in 2009 as SVP and chief medical officer of its Rhythm Management business. Biosense Webster’s new president Johnson & Johnson’s Biosense Webster chose Jasmina Brooks as its next president. She succeeds Michael Bodner, who is now the global head of heart recovery for J&J MedTech. BD elevates Brooke Story Becton, Dickinson & Co. (BD) promoted Brooke Story to president of its Surgery unit . She previously served as president of the Integrated Diagnostic Solutions unit. Story joined BD in 2021 after 15 years at Medtronic, where she led the Pelvic Health and Gastric Therapies business. Insulet restructures executive team Insulet shuffled its leadership team to accelerate innovation and commercialization, splitting the role of chief commercial officer into two new leadership positions for the automated insulin delivery technology developer. Eric Benjamin, who served as EVP of innovation and strategy, became chief product and consumer experience officer (CPXO). Mark Field, previously the group VP of software engineering, took over as chief technology officer. Insulet EVP and Chief Commercial Officer Bret Christensen left the company and later became CEO and president of DermTech, a noninvasive skin genomics platform developer. Dexcom hires first chief commercial officer Dexcom appointed medtech veteran Teri Lawver to the newly created role of chief commercial officer. Lawver spent two decades in leadership roles at Johnson & Johnson, spanning the medical device, consumer medtech and pharmaceutical sectors. LivaNova searches for a new CEO LivaNova CEO Damien McDonald resigned following several pipeline disappointments, including its Caisson transcatheter mitral valve replacement and a heart failure indication for vagal nerve stimulation. LivaNova Chair William Kozy has served as interim CEO since then. LivaNova has not named a permanent CEO. iRhythm’s COO resigns iRhythm Chief Operating Officer Douglas Devine resigned in a move that the company said related to its ongoing “business transformation.” Devine — who previously served as CFO — will remain an executive advisor through July 3, 2024. CFO leaves Integra Lifesciences Integra Lifesciences CFO Carrie Anderson left medtech to serve as EVP and CFO of Campbell Soup Co. Read more on the top personnel moves of 2023 — in the first half and last half of the year — at MassDevice.

NexoBrid® commercially launched in U.S. and Japan; Company prioritizes operational resources to meet increased global demand EscharEx® Phase III study preparations progressing; Protocol submission to FDA expected in first quarter 2024 Cash of $46 million; Operating cash runway through profitability Conference call on Tuesday, November 21 at 8:30 a.m. Eastern Time YAVNE, Israel, Nov. 21, 2023 (GLOBE NEWSWIRE) -- MediWound Ltd. (Nasdaq: MDWD), the global leader in next-generation enzymatic therapeutics for tissue repair, today announced financial results for the third quarter ended September 30, 2023, and provided a corporate update. "This quarter marks a pivotal period for us, with significant achievements that set the stage for consistent future revenue growth. NexoBrid® was successfully launched in two key markets, the U.S. and Japan, enhancing our global footprint. In Europe, the potential expansion of the pediatric indication and our recent partnership with PolyMedics Innovations are key drivers for increased sales,” said Ofer Gonen, CEO of MediWound. “Global conflicts have also escalated the demand for NexoBrid: We have secured funding from the U.S. Department of Defense to develop field-care burn treatment for the U.S. Army; The entire non-U.S. NexoBrid inventory has been deployed to successfully treat those affected by the war in Israel. The successful outcomes in the field catalyzed additional interest from various governments. We have therefore prioritized our resources to meet the increased demand. Looking ahead, preparations for the Phase III study of EscharEx® are progressing, with an updated protocol shaped by U.S. Food & Drug Administration (FDA) and European Medicines Agency (EMA) guidance. Anticipated enrollment is set to begin in the second half of 2024. A new collaboration with industry leader, 3M Healthcare, further validates EscharEx’s anticipated impact on the wound care market,” concluded Ofer Gonen. Third Quarter 2023 Highlights and Recent Developments: NexoBrid® Announced U.S. commercial availability of NexoBrid for the removal of eschar in adults with deep partial- and/or full-thickness thermal burns, with the Company’s U.S. strategic partner, Vericel Corporation. Announced commercial availability of NexoBrid in Japan for the treatment of deep partial thickness and full thickness burns in adults and pediatric patients with the Company’s strategic partner, Kaken Pharmaceutical Co., a top ranked Japanese pharmaceutical company. Deployed all available non-U.S. NexoBrid inventory to support the emergency demand from hospitals and military to treat mass burn casualties resulting from the war in Israel. Responded to surging U.S. and global demand for NexoBrid by strategically reallocating resources to prioritize production and the scale-up of manufacturing capabilities. The new GMP-compliant state-of-the-art manufacturing facility is projected to be completed by mid-2024, with full-scale manufacturing currently expected to commence in 2025. Announced positive Committee for Medicinal Products for Human Use (CHMP) opinion recommending a change to the terms of the marketing authorization for NexoBrid in Europe to include all age groups for the removal of eschar in patients with deep partial- and full-thickness thermal burns. Expanded European market presence by establishing a collaboration with PolyMedics Innovations (PMI) for the promotion of NexoBrid in Germany, Austria, Belgium, the Netherlands and Luxembourg. Secured $6.5 million R&D budget from the U.S. Department of Defense to advance the development of a new, temperature stable formulation of NexoBrid to be used by the U.S. Army as a first line, non-surgical solution for field-care burn treatment. Positive results from the NexoBrid U.S. Phase III (DETECT) study were published in the Journal of Burn Care & Research, demonstrating that treatment with NexoBrid resulted in early complete eschar removal in more than 90% of treated burn patients and reduced the need for surgical excision compared to gel vehicle and standard of care. EscharEx® An updated Phase III protocol will be submitted in the first quarter of 2024 in accordance with recent discussions with the U.S. FDA and EMA. Simultaneously, plans are underway for other exploratory studies aimed at supporting the Biologics License Application (BLA) for EscharEx and enhancing future commercialization and market access strategies. The global Phase III clinical trial intends to enroll approximately 216 patients, randomly assigned in a 1:1 ratio to receive either EscharEx or the placebo gel vehicle. The study's co-primary endpoints are the incidence of complete debridement at the end of the daily visit period and the incidence of wound closure by the end of weekly follow-ups. An interim assessment is planned after 67% of the participants have completed the trial. Patient enrollment is currently expected to commence in the second half of 2024. Established research and development partnership with 3M Healthcare, adding to previously announced partnerships with MIMEDX, and Mölnlycke, to provide product and support for the EscharEx Phase III clinical study. Corporate Development Appointed Shmulik Hess, Ph.D. as the Chief Operating Officer and Chief Commercial Officer effective as of December 1, 2023. Dr. Hess brings extensive global expertise in operations and commercial activities, along with a proven track record of success during pivotal phases in a company's development. His capabilities will significantly contribute to fortifying the Company as a world-class operation. Cash, restricted cash, and investments totaled $46 million as of September 30, 2023, ensuring an operating cash runway that extends through profitability. Third Quarter 2023 Financial Highlights Revenues: Revenues for the third quarter of 2023 were $4.8 million, compared to $5.8 million in the same quarter of the previous year. The decrease is primarily attributed to the absence of nonrecurring income from BARDA. Gross Profit: Gross profit in the third quarter 2023 was $0.9 million, representing 19% of total revenues, compared to $2.4 million, representing 41.9% of total revenue in the third quarter of 2022. The decrease is primarily attributed to the absence of nonrecurring income from BARDA. Expenditures: Research and development expenses in the third quarter of 2023 were $1.5 million compared to $2.9 million in the third quarter of 2022. This change is primarily attributed to the completion of EscharEx phase II study in 2022.Selling, general, and administrative expenses in the third quarter of 2023 were $2.6 million, compared to $3.1 million in the third quarter of 2022. Operating Results: Operating loss in the third quarter of 2023 was $3.0 million, compared to $3.5 million loss in the third quarter of 2022. Net Loss: Net loss in the third quarter of 2023 was $2.2 million or $0.24 per share, compared to the net loss of $4.2 million, or $0.88 per share in the third quarter of 2022. The decrease is primarily attributed to a favorable adjustment from the revaluation of warrants. Non-GAAP Adjusted EBITDA: Adjusted EBITDA in the third quarter of 2023 was a loss of $2.6 million, compared to a loss of $2.5 million in the third quarter of 2022. Year-to-Date 2023 Financial Highlights Revenues: Total revenues for the first nine months of 2023 were $13.3 million, compared to $14.9 million in the first nine months of 2022. The decrease is primarily attributed to the absence of nonrecurring income from BARDA.Operating results: Operating loss for the first nine months of 2023 was $11.4 million, compared to the operating loss of $10.5 million recorded in the first nine months of 2022.Net loss: Net loss for the first nine months of 2023 was $5 million, or $0.56 per share compared to a net loss of $12.1 million or $2.67 per share for the first nine months of 2022.Non-GAAP Adjusted EBITDA: Adjusted EBITDA, for the first nine months of 2023, showed a loss of $9 million, compared to a loss of $7.9 million reported in the first nine months of 2022. Balance Sheet Overview As of September 30, 2023, the Company's cash, restricted cash, and investments were $46 million, compared to $34.1 million reported on December 31, 2022. In the first quarter of 2023, the Company raised a gross amount of $27.5 million through a registered direct offering. During the third quarter of 2023, the Company used $5.4 million to fund its activities. Existing cash and cash equivalents are expected to provide sufficient funds for the Company’s current operating plan through profitability. The Company’s issued and outstanding shares of NIS 0.07 par value as of December 31, 2022, June 30, 2023, and September 30, 2023, were 7,240,020, 9,216,520 and 9,219,261, respectively. Conference Call MediWound management will host a conference call for investors on Tuesday, November 21, 2023, beginning at 8:30 a.m. Eastern Time to discuss these results and answer questions. Shareholders and other interested parties may participate in the conference call by dialing 1-833-630-1956 (in the U.S.), 1-80-921-2373 (Israel), or 1-412-317-1837 (outside the U.S. & Israel). The call will be available via webcast by clicking HERE or on the Events & Presentations page of the Company’s website. A replay of the call will be available on the Company’s website at www.mediwound.com. Non-IFRS Financial Measures To supplement consolidated financial statements prepared and presented in accordance with IFRS, the Company has provided a supplementary non-IFRS measure to consider in evaluating the Company's performance. Management uses Adjusted EBITDA, which it defines as earnings before interest, taxes, depreciation and amortization, impairment, one-time expenses, restructuring and share-based compensation expenses. Although Adjusted EBITDA is not a measure of performance or liquidity calculated in accordance with IFRS, we believe the non-IFRS financial measures we present provide meaningful supplemental information regarding our operating results primarily because they exclude certain non-cash charges or items that we do not believe are reflective of our ongoing operating results when budgeting, planning and forecasting and determining compensation, and when assessing the performance of our business with our senior management. However, investors should not consider these measures in isolation or as substitutes for operating income, cash flows from operating activities or any other measure for determining the Company's operating performance or liquidity that is calculated in accordance with IFRS. In addition, because Adjusted EBITDA is not calculated in accordance with IFRS, it may not necessarily be comparable to similarly titled measures employed by other companies. The non-IFRS measures included in this press release have been reconciled to the IFRS results in the tables below. About MediWound MediWound Ltd. (Nasdaq: MDWD) is the global leader in next-generation enzymatic therapeutics focused on non-surgical tissue repair. Specializing in the development, production and commercialization of solutions that seek to replace existing standards of care. The Company is committed to providing rapid and effective biologics that improve patient experiences and outcomes, while reducing costs and unnecessary surgeries. MediWound’s first drug, NexoBrid®, is an FDA-approved orphan biologic for eschar removal in severe burns that can replace surgical interventions and minimize associated costs and complications. Utilizing the same core biotherapeutic enzymatic platform technology, MediWound has developed a strong R&D pipeline including the Company’s lead drug under development, EscharEx®. EscharEx is a Phase III biologic for debridement of chronic wounds with significant advantages over the $300 million monopoly legacy drug and an opportunity to expand the market. MediWound’s pipeline also includes MW005, a topical therapeutic for the treatment of basal cell carcinoma that has demonstrated positive results in a recently completed Phase I/II study. For more information, please visit www.mediwound.com and follow the Company on LinkedIn. Cautionary Note Regarding Forward-Looking Statements MediWound cautions you that all statements other than statements of historical fact included in this press release that address activities, events, or developments that we expect, believe, or anticipate will or may occur in the future are forward-looking statements. Although we believe that we have a reasonable basis for the forward-looking statements contained herein, they are based on current expectations about future events affecting us and are subject to risks, assumptions, uncertainties, and factors, all of which are difficult to predict and many of which are beyond our control. Actual results may differ materially from those expressed or implied by the forward-looking statements in this press release. These statements are often, but are not always, made through the use of words or phrases such as “anticipates,” “intends,” “estimates,” “plans,” “expects,” “continues,” “believe,” “guidance,” “outlook,” “target,” “future,” “potential,” “goals” and similar words or phrases, or future or conditional verbs such as “will,” “would,” “should,” “could,” “may,” or similar expressions. Specifically, this press release contains forward-looking statements concerning the anticipated progress, development, study design, expected data timing, objectives anticipated timelines, expectations and commercial potential of our products and product candidates, including EscharEx® and NexoBrid®. Among the factors that may cause results to be materially different from those stated herein are the inherent uncertainties associated with the uncertain, lengthy and expensive nature of the product development process; the timing and conduct of our studies of our products and product candidates, including the timing, progress and results of current and future clinical studies, and our research and development programs; the approval of regulatory submission by the FDA, the European Medicines Agency or by any other regulatory authority, our ability to obtain marketing approval of our products and product candidates in the U.S. or other markets; the clinical utility, potential advantages and timing or likelihood of regulatory filings and approvals of our products and products; our expectations regarding future growth, including our ability to develop new products; risks related to our contracts with BARDA; market acceptance of our products and product candidates; our ability to maintain adequate protection of our intellectual property; competition risks; the need for additional financing; the impact of government laws and regulations and the impact of the current global macroeconomic climate on our ability to source supplies for our operations or our ability or capacity to manufacture, sell and support the use of our products and product candidates in the future. These and other significant factors are discussed in greater detail in MediWound’s annual report on Form 20-F for the year ended December 31, 2022, filed with the Securities and Exchange Commission (“SEC”) on March 16, 2023 and Quarterly Reports on Form 6-K and other filings with the SEC from time-to-time. These forward-looking statements reflect MediWound’s current views as of the date hereof and MediWound undertakes, and specifically disclaims, any obligation to update any of these forward-looking statements to reflect a change in their respective views or events or circumstances that occur after the date of this release except as required by law. Contacts: Hani Luxenburg Chief Financial Officer MediWound Ltd.ir@mediwound.comDaniel Ferry Managing Director, LifeSci Advisors 617-430-7576daniel@lifesciadvisors.com MediWound, Ltd.Unaudited Condensed Interim Consolidated Statements of Financial PositionU.S. dollars in thousands September 30, Dec 31, 2023 2022 2022Cash and cash equivalents9,279 14,905 33,895Short-term bank deposits36,244 2,687 -Trade and other receivable4,071 4,976 9,982Inventories3,656 1,880 1,963Total current assets53,250 24,448 45,840 Other receivables483 230 364Property, plant and equipment, net6,437 2,354 2,366Right of use assets, net6,665 1,305 1,215Intangible assets, net182 248 231Total non-current assets13,767 4,137 4,176 Total assets67,017 28,585 50,016 Current maturities of non-current liabilities1,692 2,461 2,242Trade payables and accrued expenses3,680 3,565 5,656Other payables3,069 2,986 4,159Total current liabilities8,441 9,012 12,057 Deferred revenues- 31 -Warrants8,901 5,092 15,606Liabilities in respect of IIA grants7,860 8,451 7,445Liability in respect of TEVA2,394 3,076 2,788Lease liabilities5,935 952 846Severance pay liability, net436 315 360Total non-current liabilities25,526 17,917 27,045 Shareholders' equity Ordinary shares of NIS 0.07 par value: Issued and Outstanding: 9,219,261 as of September 30, 2023; 7,240,020 as of December 31, 2022, and 5,819,314 as of September 30, 202233,050 1,656 27,045Total liabilities & equity67,017 28,585 50,016 MediWound, Ltd.Unaudited Condensed Interim Consolidated Statements of Profit or Loss and Other Comprehensive Income or LossU.S. dollars in thousands Nine months ended Three months ended September 30, September 30, 2023 2022 2023 2022 Revenues13,348 14,878 4,776 5,803Cost of revenues10,489 9,871 3,880 3,369Gross profit2,859 5,007 896 2,434 Operating (Income) expenses: Research and development5,659 7,482 1,533 2,883Selling, general and administrative8,820 7,684 2,612 3,061Other (income) expenses(224) 309 (224) -Operating loss(11,396) (10,468) (3,025) (3,510) Financial income (expenses), net6,488 (1,661) 877 (684)Loss before taxes on income(4,908) (12,129) (2,148) (4,194) Taxes on income(65) (13) (48) (5)Net loss(4,973) (12,142) (2,196) (4,199) Foreign currency translation adjustments(2) 34 7 12Total comprehensive loss(4,975) (12,108) (2,189) (4,187) Basic and diluted net loss per share - USD(0.56) (2.67) (0.24) (0.88) Weighted average Number of shares used in calculating basic and diluted net loss per share8,943 4,546 9,217 4,784 MediWound, Ltd.Unaudited Condensed Interim Consolidated Statements of Cash FlowsU.S. dollars in thousands Nine months ended Three months ended September 30, September 30, 2023 2022 2023 2022Cash Flows from Operating Activities: Net loss(4,973) (12,142) (2,196) (4,199)Adjustments to reconcile net loss to net cash used in operating activities: Adjustments to profit and loss items: Depreciation and amortization957 988 339 338Share-based compensation1,642 1,304 311 707Revaluation of warrants accounted at fair value(6,705) - (782) -Revaluation of liabilities in respect of IIA grants709 812 217 330Revaluation of contingent in respect of TEVA357 404 116 132Revaluation of lease liabilities(206) (146) (184) 6Increase in severance liability, net80 64 13 9Other income(224) - (224) -Net financing income(1,395) 334 (390) 345Un-realized foreign currency (gain) loss534 465 68 (63) (4,251) 4,225 (516) 1,804Changes in asset and liability items: Decrease (increase) in trade receivables6,186 (2,445) 71 (421)Decrease (increase) in inventories(1,688) (608) (526) 139Decrease (increase) in other receivables(198) 143 (320) (187)Decrease in trade payables and accrued expenses(1,687) (1,232) (51) (1,243)Increase (decrease) in other payables and deferred revenues(1,239) (1,826) 287 (459) 1,374 (5,968) (539) (2,171)Net cash used in operating activities(7,850) (13,885) (3,251) (4,566) MediWound, Ltd.Unaudited Condensed Interim Consolidated Statements of Cash FlowsU.S. dollars in thousands Cash Flows from Investing Activities: Purchase of property and equipment(4,255) (381) (1,685) (83)Interest received1,225 3 346 3Investment in short term bank deposits, net(36,319) (2,499) (4,489) -Net cash used in investing activities(39,349) (2,877) (5,828) (80) Cash Flows from Financing Activities: Repayment of lease liabilities(574) (531) (240) (181)Proceeds from issuance of shares and warrants, net24,909 21,915 - 12,054Repayments of IIA grants, net(380) (258) (70) (96)Repayment of liabilities in respect of TEVA(834) - (417) -Net cash provided by (used in) financing activities23,121 21,126 (727) 11,777 Exchange rate differences on cash and cash equivalent balances(538) (505) (81) 45Increase (decrease) in cash and cash equivalents(24,616) 3,859 (9,887) 7,176Balance of cash and cash equivalents at the beginning of the period33,895 11,046 19,166 7,729Balance of cash and cash equivalents at the end of the period9,279 14,905 9,279 14,905 MediWound, Ltd.Adjusted EBITDAU.S. dollars in thousands Nine months ended Three months ended September 30, September 30, 2023 2022 2023 2022 Net loss(4,973) (12,142) (2,196) (4,199)Adjustments: Financial income (expenses), net6,488 (1,661) 877 (684)Other income (expenses)224 (309) 224 -Taxes on income(65) (13) (48) (5)Depreciation and amortization(957) (988) (339) (338)Share-based compensation(1,642) (1,304) (311) (707)Total adjustments4,048 (4,275) 403 (1,734)Adjusted EBITDA(9,021) (7,867) (2,599) (2,465)

Following the planned spinoff from 3M, the new company comprised of 3M's healthcare business will be known as Solventum. Solventum originates from two words: "solving" and "momentum." 3M said "Solving" captures the company's dedication to finding breakthrough solutions, while "momentum" symbolizes swifter, nimbler innovation. 3M said the name represents how the independent healthcare company will focus on solving big healthcare challenges and emphasizes the impact it can make on the world. Also, the new logo takes inspiration from the future company's anticipated drive to "never stop solving" and transforms the "S" from the name into an expressive symbol of limitlessness. 3M said the logo was designed to convey the responsive, imaginative, and caring approach the company plans to take in solving for patients and healthcare professionals. "This is another significant milestone on the path to building two-world class companies, 3M and Solventum," said 3M CEO Mike Roman. "We continue to prepare for the spinoff, and we're committed to driving long-term value for shareholders." In August, Bryan Hanson abruptly stepped down from his post at the helm of Zimmer Biomet to serve as CEO of 3M's healthcare spinoff. "As we build this new company, Solventum will embody our mission of enabling better, smarter, safer healthcare to improve lives," Hanson said. "The name signifies who we are as a team problem solvers who create innovative solutions that touch millions of lives, transform the patient experience and save time for healthcare professionals." The new name and branding will go into effect when the spinoff of the independent healthcare company occurs, which is expected in the first half of 2024, subject to final approval by 3M's board and other required conditions. The business will focus on wound care, healthcare IT, oral care, filtration and purification, which resulted in $8.4 billion in sales for 3M in 2022.