Last update 24 Jun 2024
BI-1323495
Last update 24 Jun 2024
Overview
Basic Info
Drug Type Small molecule drug |
Synonyms BI 1323495 |
Target |
Mechanism ELA2 inhibitors(Leukocyte elastase inhibitors) |
Therapeutic Areas |
Active Indication- |
Inactive Indication |
Originator Organization |
Active Organization- |
Inactive Organization |
Drug Highest PhasePendingPhase 1 |
First Approval Date- |
Regulation- |
Related
8
Clinical Trials associated with BI-1323495Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Different Oral Doses of BI 1323495 Bid Versus Placebo in Patients With Non-cystic Fibrosis Bronchiectasis (Randomised, Double-blind, Placebo-controlled, Parallel Group Trial)
Safety, tolerability and pharmacokinetics of single rising oral doses and multiple oral doses of BI 1323495 versus placebo in healthy male Japanese subjects genotyped as poor and extensive metabolizers of UGT2B17 (single-blind, randomised, placebo-controlled [within dose groups] trial), including an investigation of drug-drug interaction with itraconazole in healthy male subjects genotyped as poor metabolizers of UGT2B17 (an open-label, two-period, fixed sequence trial)
Safety, Tolerability and Pharmacokinetics of Single Rising Oral Doses and Multiple Oral Doses of BI 1323495 Versus Placebo in Healthy Male Japanese Subjects Genotyped as Poor and Extensive Metabolizers of UGT2B17 (Single-blind, Randomised, Placebo-controlled [Within Dose Groups] Trial), Including an Investigation of Drug-drug Interaction With Itraconazole in Healthy Male Subjects Genotyped as Poor Metabolizers of UGT2B17 (an Open-label, Two-period, Fixed Sequence Trial)
100 Clinical Results associated with BI-1323495
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100 Translational Medicine associated with BI-1323495
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100 Patents (Medical) associated with BI-1323495
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100 Deals associated with BI-1323495
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R&D Status
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| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Inflammation | Phase 1 | DE | 04 Mar 2021 | |
| Inflammation | Phase 1 | GB | 04 Mar 2021 | |
| Non-cystic fibrosis bronchiectasis | Phase 1 | DE | 04 Mar 2021 | |
| Non-cystic fibrosis bronchiectasis | Phase 1 | GB | 04 Mar 2021 |
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Clinical Result
Clinical Result
Indication
Phase
Evaluation
View All Results
Phase 1 | - | 28 | (Rosuvastatin (Part 1, Reference 1)) | krufvnpzsc(utgngwyvub) = bugimntnoj mmbkvqroeq (eiflsgvnas, wmraesfspg - cjwqztbzir) View more | - | 23 Feb 2024 | |
(Rosuvastatin + BI 1323495 (Part 1, Test 1)) | krufvnpzsc(utgngwyvub) = fsyyzlaupe mmbkvqroeq (eiflsgvnas, vhctniqkws - lxqppdmifh) View more | ||||||
Phase 1 | - | 87 | Placebo+Midazolam (Placebo/Placebo+ Midazolam) | qqbzyxdllz(nciybaflqp) = tgmzderuhk rzxrtovxrf (qisnmpttbi, cvwddztbgn - xxsaaetnif) View more | - | 22 Feb 2024 | |
(10 mg BI 1323495 Bid EM) | qqbzyxdllz(nciybaflqp) = uysvbqzpst rzxrtovxrf (qisnmpttbi, lpqlxzdtzq - ohbqwrlfkp) View more | ||||||
Phase 1 | - | 63 | (Placebo Matching BI 1323495) | alkhkfprog(zmzesbhtgk) = kougtmmlec bplegblyzy (sorafdwzrt, cyqfksfqsb - ujdpyxuqgv) View more | - | 22 Feb 2024 | |
(BI 1323495 Dose Group 1) | alkhkfprog(zmzesbhtgk) = vyrkjxyfdi bplegblyzy (sorafdwzrt, rdesvqrcww - lkftrxguok) View more | ||||||
Phase 1 | - | 14 | (BI 1323495 (R)) | gpkmgwaqlm(aolacvagju) = jmlymqpiqv iamznyovsp (twlcbtivhc, izpnhqtuzl - kzoprorpxq) View more | - | 22 Feb 2024 | |
(BI 1323495 + Itraconazole (T)) | gpkmgwaqlm(aolacvagju) = ekogevbvsf iamznyovsp (twlcbtivhc, riwrpmqbcg - khojqhdvdg) View more | ||||||
Phase 1 | - | 12 | (BI 1323495 Fed (T)) | yylvfqsmop(okatbtslxa) = snipvonylz hzqtnfhgzw (westixalaw, djzmffjlci - neatycdmfg) View more | - | 22 Feb 2024 | |
(BI 1323495 Fasted (R)) | yylvfqsmop(okatbtslxa) = efctcwtrer hzqtnfhgzw (westixalaw, kmeobdkjtp - wirbrhtucw) View more |
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