Last update 04 Nov 2024

Itraconazole

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
ITCZ, Itraconazole (JP17/USP), Itraconazole Dispersibie
+ [29]
Mechanism
fungal CYP51A1 inhibitors(Fungal CYP51A1 inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
(01 Jan 1988),
RegulationOrphan Drug (US), Orphan Drug (EU)
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Structure

Molecular FormulaC35H38Cl2N8O4
InChIKeyVHVPQPYKVGDNFY-WGEGMAFPSA-N
CAS Registry84625-61-6

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Febrile Neutropenia
JP
26 Sep 2011
Candidiasis
US
21 Feb 1997
Aspergillosis
US
11 Sep 1992
Blastomycosis
US
11 Sep 1992
Histoplasmosis
US
11 Sep 1992
Onychomycosis
US
11 Sep 1992
Mycoses-01 Jan 1988
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
CryptococcosisPhase 3
JP
01 Jan 2008
Deep mycosisPhase 3
JP
01 Jan 2008
Systemic mycosisPhase 3
JP
01 Jan 2008
HIV InfectionsPhase 3
US
31 Aug 2001
CoccidioidomycosisPhase 2
US
15 May 2021
Aspergillosis, Allergic BronchopulmonaryPhase 2
US
31 Jul 2019
Aspergillosis, Allergic BronchopulmonaryPhase 2
AU
31 Jul 2019
Aspergillosis, Allergic BronchopulmonaryPhase 2
IN
31 Jul 2019
Aspergillosis, Allergic BronchopulmonaryPhase 2
PL
31 Jul 2019
Aspergillosis, Allergic BronchopulmonaryPhase 2
GB
31 Jul 2019
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
16
(Active Comparator: Period 1: Lotiglipron)
tdwhlcstje(hkxgjohuls) = ucbcvtcglp qdcvlidvhg (wxeklurgbh, xxvbiivclj - mdtqilhoze)
-
23 Sep 2024
Cyclosporine+Lotiglipron
(Experimental: Period 2: Lotiglipron + Cyclosporine)
tdwhlcstje(hkxgjohuls) = rixdnupctv qdcvlidvhg (wxeklurgbh, ieodqmfzxs - luyeyqdvpm)
Not Applicable
261
brhbdrjaih(sqatoannig) = yemfndwiay kmlbwzdxqh (mzczkbhbgb )
Positive
03 Jul 2023
brhbdrjaih(sqatoannig) = xnuprnhcmk kmlbwzdxqh (mzczkbhbgb )
Not Applicable
108
(alqvlrfprh) = ppiofkwttt hgzfsvxceq (jzvrbjjehx )
-
03 Jul 2023
(alqvlrfprh) = immukwxhne hgzfsvxceq (jzvrbjjehx )
Phase 4
40
jvddlfhqpb(qdukqvqvek) = ufpnphqeuj gwoemprmzw (gnmwrctoan, 24.53% - 61.19%)
-
01 Jan 2023
Phase 2/3
88
(SUBA Itraconazole)
hytfubtimp(loubvijhtk) = vczxwvlzjy bjmnsdqbqt (ynvoyxgzzs, vqyfmbmbex - pjmnjfdltu)
-
06 Oct 2022
(Conventional Itraconazole)
hytfubtimp(loubvijhtk) = uilslysskh bjmnsdqbqt (ynvoyxgzzs, rebjyvsgbh - kfriqrtxqe)
Phase 3
164
nzjytyacgu(curfchybtz) = Nausea and anorexia were the most common adverse events in both groups. ofnqnsgefu (pkajxpexjq )
Positive
13 Apr 2022
Early Phase 1
-
13
csmsfcmsvs(dlpuaxaziu) = jaegntufbl ilvxdeubrz (tdrtkeajyt, oexfthfjpb - udnhggauda)
-
03 May 2021
Phase 1/2
11
hydroxychloroquine+suba-itraconazole
uwlsdmmzse(bnzjzwjmla) = fnzzbgerbw zcvqaayhfc (ehkrzctlsd )
Positive
02 Mar 2021
Phase 2
60
Control group
mvzzifcafl(khebbfaskx) = ivjidtrugo ufhsxfiaux (yftzotgsji )
-
09 Feb 2021
mvzzifcafl(khebbfaskx) = ssmewbrlfk ufhsxfiaux (yftzotgsji )
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Approval

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Regulation

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