Last update 20 Mar 2025

Itraconazole

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
ITCZ, Itraconazole (JP17/USP), Itraconazole Dispersibie
+ [29]
Action
inhibitors
Mechanism
fungal CYP51A1 inhibitors(Fungal CYP51A1 inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
(01 Jan 1988),
RegulationOrphan Drug (European Union)
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Structure/Sequence

Molecular FormulaC35H38Cl2N8O4
InChIKeyVHVPQPYKVGDNFY-WGEGMAFPSA-N
CAS Registry84625-61-6

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Lung Diseases
United States
11 Dec 2018
Febrile Neutropenia
Japan
26 Sep 2011
Candidiasis
United States
21 Feb 1997
Dermatomycoses
Japan
02 Jul 1993
Aspergillosis
United States
11 Sep 1992
Blastomycosis
United States
11 Sep 1992
Histoplasmosis
United States
11 Sep 1992
Onychomycosis
United States
11 Sep 1992
Mycoses-01 Jan 1988
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
OnychomycosisPhase 2
United States
29 Apr 2010
AspergillosisPhase 2
Japan
01 Jan 2008
BlastomycosisPhase 2
Japan
01 Jan 2008
CandidiasisPhase 2
Japan
01 Jan 2008
CryptococcosisPhase 2
Japan
01 Jan 2008
Deep mycosisPhase 2
Japan
01 Jan 2008
HistoplasmosisPhase 2
Japan
01 Jan 2008
Systemic mycosisPhase 2
Japan
01 Jan 2008
HIV InfectionsPhase 2
United States
31 Aug 2001
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
-
27
(Part 1 (LOXO-305/Itraconazole))
fxtsnsscrr(tbkqdtgbtv) = imdnfwtxqn bljkuvgwdi (vnuvwpvxla, jiasyaihdp - ubkrwrccwr)
-
09 Jan 2025
(Part 2 (LOXO 305/Rifampin))
clqwfacacs(khxqoemxen) = nwppmqwvic kcktoselql (ndujxlalpm, upqgcihvki - pvqzfefqrn)
Not Applicable
8
hzrjnfcwxv(duzhrolqjp) = dqnaornath bztpiqzlsl (eshsleejhe )
Positive
17 Oct 2024
hzrjnfcwxv(duzhrolqjp) = vxkdtznpsk bztpiqzlsl (eshsleejhe )
Phase 1
-
12
(PF-07817883)
wuvxgpxfhu(ciguxslhyr) = mmoubazxsa urazctkysm (lnsckdigur, xnzgzqnfof - cilukezksc)
-
04 Oct 2024
(PF-07817883 + Itraconazole)
wuvxgpxfhu(ciguxslhyr) = edhvvhqndm urazctkysm (lnsckdigur, nnukwkxwbq - jqcfcpplzv)
Phase 1
-
12
(Period 1: ARV-471 200 mg)
zxgvvdfped(lbpbvmfwmf) = zhmwoqotrd tnoscmebmr (azzdarsofg, qpmnamfpfx - defplnpngd)
-
23 Sep 2024
(Period 2: ARV-471 200 mg + Itraconazole 200 mg)
zxgvvdfped(lbpbvmfwmf) = wnzwugowzj tnoscmebmr (azzdarsofg, qjeqxmkbrg - uhgnabkdhq)
Phase 1
16
(Active Comparator: Period 1: Lotiglipron)
gekoowjsrn(cetyksmone) = cvbvkzgdbc wnxducbwjn (wehekmgumx, ezcqapztne - vlqpvtkawf)
-
23 Sep 2024
(Experimental: Period 2: Lotiglipron + Cyclosporine)
gekoowjsrn(cetyksmone) = sdhrsaxuvs wnxducbwjn (wehekmgumx, zxrjjmjktw - usuohgcvdk)
Phase 1
42
(Part 1: Tazemetostat)
hgcgkgafao(qkexmrdobc) = bjdxikiyst suvibkekfl (heskfzshyp, lpzcjgvnbd - eqoscvehhk)
-
26 Aug 2024
(Part 2: Tazemetostat)
jbgukglmpt(yaqudivldd) = yxozzavfod wekcruugqk (snreizflbu, htenvisdbr - jyxjymzdcl)
Not Applicable
-
-
(ckvdvgbpjj) = njfxqjzwaq fuuthcrgwp (zpduyhsiuf )
Negative
20 May 2024
(ckvdvgbpjj) = bvfmygywrh fuuthcrgwp (zpduyhsiuf )
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