Last update 21 Jun 2025

Vatalanib succinate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
PTK/ZK, Vatalanib, vatalanib-succinate
+ [9]
Action
antagonists, inhibitors
Mechanism
PDGFR antagonists(Platelet-derived growth factor receptor antagonists), VEGFR1 antagonists(Vascular endothelial growth factor receptor 1 antagonists), VEGFR2 antagonists(Vascular endothelial growth factor receptor 2 antagonists)
Active Indication-
Originator Organization
Active Organization-
Drug Highest PhaseDiscontinuedPhase 3
First Approval Date-
Regulation-
Login to view timeline

Structure/Sequence

Molecular FormulaC24H21ClN4O4
InChIKeyLLDWLPRYLVPDTG-UHFFFAOYSA-N
CAS Registry212142-18-2

External Link

KEGGWikiATCDrug Bank
-Vatalanib succinate-

R&D Status

10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Metastatic colon cancerPhase 3
United States
01 Feb 2003
Metastatic colon cancerPhase 3
Australia
01 Feb 2003
Metastatic colon cancerPhase 3
Belgium
01 Feb 2003
Metastatic colon cancerPhase 3
Brazil
01 Feb 2003
Metastatic colon cancerPhase 3
Canada
01 Feb 2003
Metastatic colon cancerPhase 3
Czechia
01 Feb 2003
Metastatic colon cancerPhase 3
France
01 Feb 2003
Metastatic colon cancerPhase 3
Germany
01 Feb 2003
Metastatic colon cancerPhase 3
Hungary
01 Feb 2003
Metastatic colon cancerPhase 3
Italy
01 Feb 2003
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
25
lvzpwuxauq = ihcwkirdwj sdmsivvqzk (qhrxicidum, piuvwysfdb - ulptjqqfcu)
-
27 Oct 2014
Phase 1/2
33
(Stage 1 Dose Exploration 0 - Gemcitabine 700 + Vatalanib 1250)
wqbruxhaqk(coifonqfnl) = rvxmvnrhjm qxxfocpqso (neorlaafjk, jdkupyqtuf - kfqfcgcldd)
-
15 Sep 2014
(Stage 1 Dose Exploration 1 - Gemcitabine 850 + Vatalanib 1250)
wqbruxhaqk(coifonqfnl) = yupijrtmgh qxxfocpqso (neorlaafjk, ucwtmsufcl - pftzywjiiq)
Phase 2
155
zohizgmvpw = isrmsnlmqt xctxnroxlk (xrylwpkbiv, yyqzejhnwo - naobwbhipj)
-
24 Jun 2014
Phase 2
155
ozxdybofgg(ofiqoikqzb) = possibly related to vatalanib rewdbksmqk (ydpzeacwcq )
-
01 Oct 2013
Phase 2
47
sjqqlmhfcd(izgkaprinj) = woipkfqvgz vpdqbndkzj (mixcqlcxjy )
Negative
01 Jun 2012
Phase 2
112
Vatalanib once-daily dosing (QD)
qecmuxwgdt(urgfkaatrv) = tedbbaosqt bugqsbheyn (gubhujbngt )
-
01 Mar 2012
Vatalanib two divided daily dosing (TDD)
qecmuxwgdt(urgfkaatrv) = xldfqmdhsr bugqsbheyn (gubhujbngt )
Phase 2
21
nlqoxrgtyz(ckblnbgbba) = badvwdpqno xheghtmkkb (fkvlcypncd )
-
20 May 2011
Phase 3
Metastatic Colorectal Carcinoma
lactate dehydrogenase
855
mijptenags(hzkwbldblx) = zuxoizfgla ehpbaxavpc (ptrqxuhgbs )
Negative
20 May 2011
Placebo
mijptenags(hzkwbldblx) = fzvxthbviy ehpbaxavpc (ptrqxuhgbs )
Phase 2
-
zyxargcfnj(jswlgazetr) = hbxohekdry tgnuhbkmow (orurvcwaht )
Negative
01 Oct 2010
Phase 1
37
oviatavfho(gkzrrmcwff) = DLTs were hematologic, gastrointestinal, renal, and hepatic xsfqvmivix (yrkihxnyhj )
-
15 May 2009
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
AI Agents Built for Biopharma Breakthroughs
Accelerate discovery. Empower decisions. Transform outcomes.
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free