Drug Type Small molecule drug |
Synonyms PTK/ZK, Vatalanib, vatalanib-succinate + [9] |
Action antagonists, inhibitors |
Mechanism PDGFR antagonists(Platelet-derived growth factor receptor antagonists), VEGFR1 antagonists(Vascular endothelial growth factor receptor 1 antagonists), VEGFR2 antagonists(Vascular endothelial growth factor receptor 2 antagonists) |
Therapeutic Areas |
Active Indication- |
Inactive Indication |
Originator Organization |
Active Organization- |
Inactive Organization |
License Organization |
Drug Highest PhaseDiscontinuedPhase 3 |
First Approval Date- |
Regulation- |
Molecular FormulaC24H21ClN4O4 |
InChIKeyLLDWLPRYLVPDTG-UHFFFAOYSA-N |
CAS Registry212142-18-2 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | Vatalanib succinate | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Metastatic colon cancer | Phase 3 | United States | 01 Feb 2003 | |
Metastatic colon cancer | Phase 3 | Australia | 01 Feb 2003 | |
Metastatic colon cancer | Phase 3 | Belgium | 01 Feb 2003 | |
Metastatic colon cancer | Phase 3 | Brazil | 01 Feb 2003 | |
Metastatic colon cancer | Phase 3 | Canada | 01 Feb 2003 | |
Metastatic colon cancer | Phase 3 | Czechia | 01 Feb 2003 | |
Metastatic colon cancer | Phase 3 | France | 01 Feb 2003 | |
Metastatic colon cancer | Phase 3 | Germany | 01 Feb 2003 | |
Metastatic colon cancer | Phase 3 | Hungary | 01 Feb 2003 | |
Metastatic colon cancer | Phase 3 | Italy | 01 Feb 2003 |
Phase 2 | 25 | lvzpwuxauq = ihcwkirdwj sdmsivvqzk (qhrxicidum, piuvwysfdb - ulptjqqfcu) View more | - | 27 Oct 2014 | |||
Phase 1/2 | 33 | (Stage 1 Dose Exploration 0 - Gemcitabine 700 + Vatalanib 1250) | wqbruxhaqk(coifonqfnl) = rvxmvnrhjm qxxfocpqso (neorlaafjk, jdkupyqtuf - kfqfcgcldd) View more | - | 15 Sep 2014 | ||
(Stage 1 Dose Exploration 1 - Gemcitabine 850 + Vatalanib 1250) | wqbruxhaqk(coifonqfnl) = yupijrtmgh qxxfocpqso (neorlaafjk, ucwtmsufcl - pftzywjiiq) View more | ||||||
Phase 2 | 155 | zohizgmvpw = isrmsnlmqt xctxnroxlk (xrylwpkbiv, yyqzejhnwo - naobwbhipj) View more | - | 24 Jun 2014 | |||
Phase 2 | 155 | ozxdybofgg(ofiqoikqzb) = possibly related to vatalanib rewdbksmqk (ydpzeacwcq ) View more | - | 01 Oct 2013 | |||
Phase 2 | 47 | sjqqlmhfcd(izgkaprinj) = woipkfqvgz vpdqbndkzj (mixcqlcxjy ) View more | Negative | 01 Jun 2012 | |||
Phase 2 | Non-Small Cell Lung Cancer Second line | 112 | Vatalanib once-daily dosing (QD) | qecmuxwgdt(urgfkaatrv) = tedbbaosqt bugqsbheyn (gubhujbngt ) View more | - | 01 Mar 2012 | |
Vatalanib two divided daily dosing (TDD) | qecmuxwgdt(urgfkaatrv) = xldfqmdhsr bugqsbheyn (gubhujbngt ) View more | ||||||
Phase 2 | 21 | nlqoxrgtyz(ckblnbgbba) = badvwdpqno xheghtmkkb (fkvlcypncd ) | - | 20 May 2011 | |||
Phase 3 | Metastatic Colorectal Carcinoma lactate dehydrogenase | 855 | mijptenags(hzkwbldblx) = zuxoizfgla ehpbaxavpc (ptrqxuhgbs ) View more | Negative | 20 May 2011 | ||
Placebo | mijptenags(hzkwbldblx) = fzvxthbviy ehpbaxavpc (ptrqxuhgbs ) View more | ||||||
Phase 2 | - | zyxargcfnj(jswlgazetr) = hbxohekdry tgnuhbkmow (orurvcwaht ) View more | Negative | 01 Oct 2010 | |||
Phase 1 | 37 | oviatavfho(gkzrrmcwff) = DLTs were hematologic, gastrointestinal, renal, and hepatic xsfqvmivix (yrkihxnyhj ) | - | 15 May 2009 |