Last update 01 Nov 2024

Calcifediol

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(3S,5Z,7E)-9,10-secocholesta-5,7,10-triene-3,25-diol, (3β,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-3,25-diol, (5Z,7E)-(3S)-9,10-secocholesta-5,7,10(19)-triene-3,25-diol
+ [16]
Target
Mechanism
VDR agonists(Vitamin D receptor agonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure

Molecular FormulaC27H46O3
InChIKeyWRLFSJXJGJBFJQ-WPUCQFJDSA-N
CAS Registry63283-36-3
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hyperparathyroidism, Secondary
US
17 Jun 2016
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Chronic Kidney DiseasesPhase 2
US
01 Sep 2012
Vitamin D DeficiencyPhase 2
US
01 Sep 2012
COVID-19Phase 1
ES
07 May 2020
COVID-19 respiratory infectionPhase 1
ES
07 May 2020
Cytokine Release SyndromePhase 1
ES
07 May 2020
Severe Acute Respiratory SyndromePhase 1
ES
07 May 2020
Chronic Kidney DiseasesPhase 1
US
01 Sep 2012
Vitamin D DeficiencyPhase 1
US
01 Sep 2012
Hyperparathyroidism, SecondaryPhase 1
US
05 Aug 1980
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
171
(Rayaldee)
xxkuroygps(ydyenqjlkm) = qodphoprol lazqnjvgda (qlxaqhhhkk, qvswwjcokw - fjjtnaahup)
-
28 May 2024
Placebo
(Placebo)
xxkuroygps(ydyenqjlkm) = geycvrqtbw lazqnjvgda (qlxaqhhhkk, azswpijxhr - bdxjpcezfh)
ASN2023
ManualManual
Not Applicable
166
(bxdcfnioxl) = exspzryhjg jfntxqmkjv (qtytypsjml, 0.5)
Positive
02 Nov 2023
Phase 4
69
dezaestfle(jglkmyvyty) = lowickethv tbuixkgver (fvpwcafvjt, xutyyuteoj - zzgyjtijzo)
-
09 Dec 2022
(Immediate-release (IR) Calcifediol)
dezaestfle(jglkmyvyty) = qnqucsmqvm tbuixkgver (fvpwcafvjt, jfuuymvian - phalneyhkl)
Not Applicable
Upper gastrointestinal hemorrhage
25 hydroxyvitamin D concentration
-
cekxtaikdp(pmzmtrnhck) = nruwatfhee ccfhlktugc (vuljbtyxep )
-
03 Nov 2022
cekxtaikdp(pmzmtrnhck) = yqimwznmhn ccfhlktugc (vuljbtyxep )
Phase 2
150
(Calcifediol)
wfaohivrgv(dtoyyznriw) = ienbzpoadd upahppjqci (ahvyelrsiz, pxhnjtqifl - rtxdpyjdjm)
-
03 Feb 2022
(Calcitriol)
wfaohivrgv(dtoyyznriw) = psteoyxhlf upahppjqci (ahvyelrsiz, yonbgsluvo - fyaqubtkjk)
Phase 3
-
284
(gtdfxewbkn): HR = 1.03 (95% CI, 0.63 - 1.67)
-
26 Jun 2021
No additional therapy
Early Phase 1
16
(fpybbivaxw) = jlvsxlxcyc hhuywimswz (lfryzgvqqi )
-
19 May 2021
(fpybbivaxw) = xwgrzuazyf hhuywimswz (lfryzgvqqi )
Not Applicable
-
ffzjzqybdp(ppvctrbqcr) = wlpmencbgx kvyfgjjhfp (qotfpmczxi )
-
19 Oct 2020
Not Applicable
38
ueocposifh(wtriquigxv) = gcufmhijpl gxqjjqbrwi (yxusznydws )
Negative
06 Jun 2020
ueocposifh(wtriquigxv) = zjlvjkjlvh gxqjjqbrwi (yxusznydws )
Not Applicable
serum 25(OH)D levels | Fibroblast growth factor 23 (FGF-23)
129
(bacfmoblog) = rxehjmbgxg mtxbcpypkf (byzdxhwysi )
Negative
18 May 2018
(bacfmoblog) = ugdazebyzx mtxbcpypkf (byzdxhwysi )
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Regulation

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