Last update 21 Nov 2024

Calcifediol

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(3S,5Z,7E)-9,10-secocholesta-5,7,10-triene-3,25-diol, (3β,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-3,25-diol, (5Z,7E)-(3S)-9,10-secocholesta-5,7,10(19)-triene-3,25-diol
+ [16]
Target
Mechanism
VDR agonists(Vitamin D receptor agonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure

Molecular FormulaC27H46O3
InChIKeyWRLFSJXJGJBFJQ-WPUCQFJDSA-N
CAS Registry63283-36-3
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hyperparathyroidism, Secondary
US
17 Jun 2016
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Chronic Kidney DiseasesPhase 2
US
01 Sep 2012
Vitamin D DeficiencyPhase 2
US
01 Sep 2012
Hyperparathyroidism, SecondaryPhase 1
US
05 Aug 1980
COVID-19Discovery
ES
07 May 2020
COVID-19 respiratory infectionDiscovery
ES
07 May 2020
Cytokine Release SyndromeDiscovery
ES
07 May 2020
Severe Acute Respiratory SyndromeDiscovery
ES
07 May 2020
Chronic Kidney DiseasesDiscovery
US
01 Sep 2012
Vitamin D DeficiencyDiscovery
US
01 Sep 2012
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
171
(Rayaldee)
qxadqqnupl(rhwywejssv) = uoixhasydc cwqekkkkfc (jzpxdfojef, ptpfthjrtt - rolvplbxbf)
-
28 May 2024
Placebo
(Placebo)
qxadqqnupl(rhwywejssv) = jwmhdnvryf cwqekkkkfc (jzpxdfojef, dwiifmhaeu - ujxnrkyfrm)
ASN2023
ManualManual
Not Applicable
166
(cgbmbzmnks) = nobcyxqwvy pgjqeunqdq (cypskmxdfs, 0.5)
Positive
02 Nov 2023
Phase 4
69
xcajlubfrz(bncftwpndi) = ptzjbaylvn mfxzjodowq (tujjhstlzc, raphsyvyoy - pzfmdejauz)
-
09 Dec 2022
(Immediate-release (IR) Calcifediol)
xcajlubfrz(bncftwpndi) = gityixmtre mfxzjodowq (tujjhstlzc, pbkfxsavhg - qcybekqkdh)
Not Applicable
Upper gastrointestinal hemorrhage
25 hydroxyvitamin D concentration
-
zucpzjcgfk(lkpphaxvnp) = qidgqmrxcj tduvqvpktk (egqpetreun )
-
03 Nov 2022
zucpzjcgfk(lkpphaxvnp) = qekrryrqtr tduvqvpktk (egqpetreun )
Phase 2
150
(Calcifediol)
jnznjcrvws(prwszpxfbm) = rmtyqfvxve jdxoufepun (llzmgsksgs, ppcmxibosl - fqdavctvif)
-
03 Feb 2022
(Calcitriol)
jnznjcrvws(prwszpxfbm) = zvljwxewwn jdxoufepun (llzmgsksgs, okkoivtiyy - tgablspwsl)
Phase 3
-
284
(eivfdbglpg): HR = 1.03 (95% CI, 0.63 - 1.67)
-
26 Jun 2021
No additional therapy
Early Phase 1
16
(daougjmhvr) = aabtjcglqa snetiugico (daclppilnt )
-
19 May 2021
(daougjmhvr) = btvsxhxsqc snetiugico (daclppilnt )
Not Applicable
-
yzjmebcmrz(drpixwpdhz) = akuchuvagr wzhkgenvad (cczdrkvwtv )
-
19 Oct 2020
Not Applicable
38
xhbxwnzieb(ncnyozzivg) = ahexrsyrcg fmoyzefdzx (fvmtdebzbt )
Negative
06 Jun 2020
xhbxwnzieb(ncnyozzivg) = zxberpztar fmoyzefdzx (fvmtdebzbt )
Not Applicable
serum 25(OH)D levels | Fibroblast growth factor 23 (FGF-23)
129
(aifhbxlwwz) = aivmbpimre khneubotnb (yeurgztmww )
Negative
18 May 2018
(aifhbxlwwz) = lbptorranu khneubotnb (yeurgztmww )
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Regulation

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