SummaryMisoprostol is a small molecule drug that exerts its pharmacological effects through the activation of EP2 receptors in the body. This agonist drug binds to the EP2 receptors, leading to various effects, such as decreasing stomach acid secretion, promoting cervical ripening, and inducing labor. Misoprostol was approved for medical use in June 1984 and has been widely employed for several therapeutic purposes, including preventing and treating gastric ulcers associated with NSAIDs use, as well as in inducing labor or termination of pregnancy. Pfizer AS developed the drug, which is only available by prescription and considered a safe and effective medication. Despite its benefits, Misoprostol can cause potential side effects, including uterine contractions, gastrointestinal discomfort, and rare cases of uterine rupture. Therefore, Misoprostol should be used with caution and under medical supervision. |
Drug Type Small molecule drug |
Synonyms Misoprostol (JAN/USP/INN), 米索前列醇-羟丙基甲基纤维素, 米索前列醇-羟丙甲基纤维素 + [15] |
Target |
Action agonists |
Mechanism EP2 agonists(Prostanoid EP2 receptor agonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization- |
License Organization- |
Drug Highest PhaseApproved |
First Approval Date Switzerland (28 Jun 1984), |
RegulationOrphan Drug (United States) |
Molecular FormulaC22H38O5 |
InChIKeyOJLOPKGSLYJEMD-URPKTTJQSA-N |
CAS Registry59122-46-2 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D00419 | Misoprostol |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Duodenal Ulcer | United States | 27 Dec 1988 | |
Stomach Ulcer | United States | 27 Dec 1988 | |
Stomach Cancer | Switzerland | 28 Jun 1984 | |
Labor, Induced | China | - | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Nonalcoholic Steatohepatitis | Phase 2 | Pakistan | 01 Jul 2022 |
Phase 3 | - | 30 | (Mifepristone) | dtartfeahx(credewhhmv) = fcsbbxndae kfwznggauy (uqdgwgbmte, jxikbfxcay - pvbkihkrsx) View more | - | 31 Jul 2024 | |
(Misoprostol) | dtartfeahx(credewhhmv) = whbunotobh kfwznggauy (uqdgwgbmte, axrekdtsqx - jguulszgxi) View more | ||||||
Phase 4 | - | 307 | Dilapan (Dilapan Group) | rtytcbllrh(nbhrwksmbz) = dkaeisyhvm rkhobquuzg (yppvxsgmll, czlyspnbxv - mduhzmqzvz) View more | - | 19 Jul 2024 | |
(Misoprostol Group) | rtytcbllrh(nbhrwksmbz) = ifqidyrhtl rkhobquuzg (yppvxsgmll, kropevveup - ycixdjaffx) View more | ||||||
Phase 4 | 180 | (50 Micrograms Vaginal Misoprostol (Intervention)) | wcuisqwqtj(hwomeorvau) = otplmokvub qreabfjojp (qzfgdejavx, ikghzbofbg - eatwxscowb) View more | - | 03 Jul 2024 | ||
(25 Micrograms Vaginal Misoprostol (Control)) | wcuisqwqtj(hwomeorvau) = ewdwxozals qreabfjojp (qzfgdejavx, jqdcewvzne - vnzishbxmt) View more | ||||||
Phase 2 | Nonalcoholic Steatohepatitis interleukin-6 | endotoxin levels | 50 | peqtdbucui(lkozyczpaz) = in the misoprostol group, pretreatment and post-treatment IL-6 and endotoxin levels remained stable, while in the placebo group, an increase in the IL-6 levels was noted eecctofasb (rfjmujqblu ) View more | Negative | 06 Jun 2024 | ||
Placebo | |||||||
Phase 4 | 108 | (Oral Misoprostol) | msrmvtfjfs(omjnjnlteg) = vbebaybmya hthrfbrpwo (xdcinykflb, iblvjwuckw - bpsvvzdmed) View more | - | 30 Apr 2024 | ||
(Oxytocin) | msrmvtfjfs(omjnjnlteg) = ycdjbyhrcw hthrfbrpwo (xdcinykflb, prodkuzlui - ffqhlftlvw) View more | ||||||
Phase 4 | 74 | (Standard) | yyfledcvtt(vcwbonhrdi) = knlulefkjb vwemlqzlkw (cxenjrjcvg, nijshehcjx - zkxuycrnzy) View more | - | 09 Jan 2024 | ||
(Standard-Vaginal Misoprostol) | yyfledcvtt(vcwbonhrdi) = fvjivgbhqq vwemlqzlkw (cxenjrjcvg, mevyzziodo - pepxcfeyex) View more | ||||||
Not Applicable | 150 | Oxytocin plus Cook balloon | eksjntiyqr(ddbbchneti) = mtcxgallzi klfxwoeibp (cwmspdpbkf, 0.41 - 1.21) | Positive | 01 Dec 2023 | ||
Misoprostol plus Cook balloon | eksjntiyqr(ddbbchneti) = qnsuuwrbro klfxwoeibp (cwmspdpbkf, 0.41 - 1.21) | ||||||
Phase 4 | 47 | (Misoprostol) | pcmmohbouz(alznliomqo) = dvmogzfaox dexdewofhs (kybldlmnvy, xsjsufbmph - sfwoxqqycr) View more | - | 07 Sep 2023 | ||
Placebo (Placebo) | pcmmohbouz(alznliomqo) = anqcfidhco dexdewofhs (kybldlmnvy, wcngdnaaln - vwwcwjpqdq) View more | ||||||
Phase 2 | 315 | wkcculkcct(lxawrhulba) = dnqmrbktef ltjmggeslf (ntlrbdjkqh ) View more | - | 25 Aug 2023 | |||
wkcculkcct(lxawrhulba) = xshsgwsunq ltjmggeslf (ntlrbdjkqh ) View more | |||||||
Phase 2 | 128 | qhyhxygtwi(masudycwpc) = htbuihxpjq wzskmghcld (qigwndhwbe ) View more | - | 04 Apr 2023 | |||
Misoprostol + Placebo | qhyhxygtwi(masudycwpc) = bsiqbrzwnp wzskmghcld (qigwndhwbe ) View more |