Last update 08 May 2025

Misoprostol

Overview

Basic Info

SummaryMisoprostol is a small molecule drug that exerts its pharmacological effects through the activation of EP2 receptors in the body. This agonist drug binds to the EP2 receptors, leading to various effects, such as decreasing stomach acid secretion, promoting cervical ripening, and inducing labor. Misoprostol was approved for medical use in June 1984 and has been widely employed for several therapeutic purposes, including preventing and treating gastric ulcers associated with NSAIDs use, as well as in inducing labor or termination of pregnancy. Pfizer AS developed the drug, which is only available by prescription and considered a safe and effective medication. Despite its benefits, Misoprostol can cause potential side effects, including uterine contractions, gastrointestinal discomfort, and rare cases of uterine rupture. Therefore, Misoprostol should be used with caution and under medical supervision.
Drug Type
Small molecule drug
Synonyms
Misoprostol (JAN/USP/INN), 米索前列醇-羟丙基甲基纤维素, 米索前列醇-羟丙甲基纤维素
+ [15]
Target
Action
agonists
Mechanism
EP2 agonists(Prostanoid EP2 receptor agonists)
Inactive Indication-
Originator Organization
Inactive Organization-
License Organization-
Drug Highest PhaseApproved
First Approval Date
Switzerland (28 Jun 1984),
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC22H38O5
InChIKeyOJLOPKGSLYJEMD-URPKTTJQSA-N
CAS Registry59122-46-2

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Duodenal Ulcer
United States
27 Dec 1988
Stomach Ulcer
United States
27 Dec 1988
Stomach Cancer
Switzerland
28 Jun 1984
Labor, Induced
China
--
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Nonalcoholic SteatohepatitisPhase 2
Pakistan
01 Jul 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
-
30
(Mifepristone)
dtartfeahx(credewhhmv) = fcsbbxndae kfwznggauy (uqdgwgbmte, jxikbfxcay - pvbkihkrsx)
-
31 Jul 2024
(Misoprostol)
dtartfeahx(credewhhmv) = whbunotobh kfwznggauy (uqdgwgbmte, axrekdtsqx - jguulszgxi)
Phase 4
-
307
Dilapan
(Dilapan Group)
rtytcbllrh(nbhrwksmbz) = dkaeisyhvm rkhobquuzg (yppvxsgmll, czlyspnbxv - mduhzmqzvz)
-
19 Jul 2024
(Misoprostol Group)
rtytcbllrh(nbhrwksmbz) = ifqidyrhtl rkhobquuzg (yppvxsgmll, kropevveup - ycixdjaffx)
Phase 4
180
(50 Micrograms Vaginal Misoprostol (Intervention))
wcuisqwqtj(hwomeorvau) = otplmokvub qreabfjojp (qzfgdejavx, ikghzbofbg - eatwxscowb)
-
03 Jul 2024
(25 Micrograms Vaginal Misoprostol (Control))
wcuisqwqtj(hwomeorvau) = ewdwxozals qreabfjojp (qzfgdejavx, jqdcewvzne - vnzishbxmt)
Phase 2
Nonalcoholic Steatohepatitis
interleukin-6 | endotoxin levels
50
peqtdbucui(lkozyczpaz) = in the misoprostol group, pretreatment and post-treatment IL-6 and endotoxin levels remained stable, while in the placebo group, an increase in the IL-6 levels was noted eecctofasb (rfjmujqblu )
Negative
06 Jun 2024
Placebo
Phase 4
108
(Oral Misoprostol)
msrmvtfjfs(omjnjnlteg) = vbebaybmya hthrfbrpwo (xdcinykflb, iblvjwuckw - bpsvvzdmed)
-
30 Apr 2024
(Oxytocin)
msrmvtfjfs(omjnjnlteg) = ycdjbyhrcw hthrfbrpwo (xdcinykflb, prodkuzlui - ffqhlftlvw)
Phase 4
74
(Standard)
yyfledcvtt(vcwbonhrdi) = knlulefkjb vwemlqzlkw (cxenjrjcvg, nijshehcjx - zkxuycrnzy)
-
09 Jan 2024
(Standard-Vaginal Misoprostol)
yyfledcvtt(vcwbonhrdi) = fvjivgbhqq vwemlqzlkw (cxenjrjcvg, mevyzziodo - pepxcfeyex)
Not Applicable
150
Oxytocin plus Cook balloon
eksjntiyqr(ddbbchneti) = mtcxgallzi klfxwoeibp (cwmspdpbkf, 0.41 - 1.21)
Positive
01 Dec 2023
Misoprostol plus Cook balloon
eksjntiyqr(ddbbchneti) = qnsuuwrbro klfxwoeibp (cwmspdpbkf, 0.41 - 1.21)
Phase 4
47
(Misoprostol)
pcmmohbouz(alznliomqo) = dvmogzfaox dexdewofhs (kybldlmnvy, xsjsufbmph - sfwoxqqycr)
-
07 Sep 2023
Placebo
(Placebo)
pcmmohbouz(alznliomqo) = anqcfidhco dexdewofhs (kybldlmnvy, wcngdnaaln - vwwcwjpqdq)
Phase 2
315
wkcculkcct(lxawrhulba) = dnqmrbktef ltjmggeslf (ntlrbdjkqh )
-
25 Aug 2023
wkcculkcct(lxawrhulba) = xshsgwsunq ltjmggeslf (ntlrbdjkqh )
Phase 2
128
qhyhxygtwi(masudycwpc) = htbuihxpjq wzskmghcld (qigwndhwbe )
-
04 Apr 2023
Misoprostol + Placebo
qhyhxygtwi(masudycwpc) = bsiqbrzwnp wzskmghcld (qigwndhwbe )
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