Last update 23 Feb 2024

ADG-126

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
Anti-CTLA-4 Monoclonal Antibody(Adagene), ADG-126, ADG126
Target
Mechanism
CTLA4 inhibitors(Cytotoxic T-Lymphocyte-Associated Antigen 4 inhibitors)
Therapeutic Areas
Inactive Indication
Originator Organization
Active Organization
Inactive Organization-
Drug Highest PhasePhase 2
First Approval Date-
Regulation-

R&D Status

IndicationHighest PhaseCountry/LocationOrganization
Solid tumorPhase 2AU
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Advanced Malignant Solid NeoplasmPhase 1CN
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Metastatic Solid TumorPendingUS
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Clinical Trial Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
47
pmdatxszmi(kfvenskxle) = ffspazwzzg tijluzfjod (sogoagpkpv )
Positive
20 Jan 2024
(expansion cohort + ADG126 10 mpk Q6W)
idcqnbziqn(yvbipkausa) = piskvrwtqv nlpkxeoxzr (byrobeypbv )
Phase 1/2
-
tdudqgqpzz(rmfnjsftec) = TRAEs ≥10% included diarrhea (17%), fatigue (17%), pruritus (13%), and rash (10%) in monotherapy. TRAEs (> 10%) included diarrhea (21%), fatigue (14%), pruritus (14%), rash (14%) and nausea (14%) in combination therapy. tzoccyqkkp (jmavjnucdx )
Positive
14 Apr 2023
Phase 1/2
11
bjfsalwuuz(tedyinovqh) = Both ADG126 6 and 10 mg/kg dose levels on either Q3W or Q6W were well tolerated with no DLT. kdeiqddjrl (ndxmllakfw )
Positive
14 Apr 2023
Phase 1
16
akztjqnzsd(izpibmfwtj) = xvkigohkvr kypbytopby (wucnnwtedn )
Positive
02 Jun 2022
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Regulation

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