[Translation] A single-center, randomized, open-label, three-period crossover phase I clinical study to evaluate the effects of calcium-containing phosphate binder calcium acetate tablets and non-calcium-containing phosphate binder sevelamer carbonate tablets on the pharmacokinetics of dedostat tablets in healthy subjects

主要目的：评估磷结合剂碳酸司维拉姆片和醋酸钙片对德度司他片药动学的影响。次要目的：观察受试者给予磷结合剂碳酸司维拉姆片和醋酸钙片与德度司他片的安全性。

[Translation]

Primary objective: To evaluate the effect of phosphate binders sevelamer carbonate tablets and calcium acetate tablets on the pharmacokinetics of depo-depo-depo-depo-depo-depo-depo-depo-depo-depo-de- ...

Start Date13 Jul 2023

Sponsor / Collaborator

Yiqiao Hunan Pharmaceuticals Co. Ltd.

NCT05424263 / RecruitingPhase 2IIT

The Short-chain Fatty Acid Acetate for Improving Age-associated Arterial Dysfunction

Cardiovascular diseases are the leading cause of morbidity and mortality and contribute most to healthcare costs in the U.S. Age is the strongest cardiovascular disease risk factor, with >90% of all deaths from cardiovascular disease occurring in adults >50 years old. The age-associated increased risk of cardiovascular disease is due, in large part, to the development of arterial dysfunction, including endothelial dysfunction and stiffening of the large elastic arteries. Therefore, novel, effective interventions that improve arterial function will have a large public health impact by decreasing the risk of cardiovascular diseases.
The short-chain fatty acid acetate is endogenously produced by the gut microbiome from fermentation of dietary soluble fiber. High-fiber diets reduce risk of cardiovascular diseases, but unfortunately, a low percentage of Americans meet guidelines for adequate dietary fiber intake and, despite nationwide efforts to improve this, trends in fiber intake have not improved over the last 20+ years. Thus, directly supplementing acetate may be a more practical and feasible intervention for effectively improving arterial function in older adults and reducing the risk of cardiovascular diseases.
The investigators will conduct a study to determine the efficacy of 12 weeks of oral supplementation with acetate for improving arterial function in late middle-aged and older (50+ years) adults. They will also assess the safety and tolerability of acetate supplementation in these adults and perform innovative mechanistic analyses to determine how acetate supplementation improves arterial function. The investigators hypothesize that oral acetate supplementation will improve arterial function by decreasing oxidative stress and increasing nitric oxide bioavailability, and also hypothesize that acetate supplementation will be safe and promote high rates of adherence.

Start Date29 Sep 2022

Sponsor / Collaborator

University of Colorado Denver

100 Clinical Results associated with Calcium Acetate

100 Translational Medicine associated with Calcium Acetate

100 Patents (Medical) associated with Calcium Acetate

440

Literatures (Medical) associated with Calcium Acetate

01 Mar 2024·Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis

Biochemical markers of iron status and iron accumulation in peritoneal dialysis patients treated with ferric citrate

Article

Author: Lea, Janice I ; Ajiboye, Oyintayo ; Navarrete, José E

Background::

Hyperphosphataemia is a common complication of kidney disease. Current dialysis techniques do not provide enough phosphorus clearance, hence the need to use phosphorus binders. Treatment options include calcium carbonate, calcium acetate, lanthanum carbonate, sevelamer hydrochloride and iron-based binders. Patients receiving peritoneal dialysis (PD) with sustained elevated ferritin levels exceeding 800 ng/mL are at a higher risk of death. We identify PD patients treated with iron-based binders and compare ferritin and risk of iron accumulation to patients treated with non-iron-based binders.

Methods::

All records of patients receiving PD at Emory dialysis centres until 30 October 2021 were reviewed for phosphorus binders. Basic demographics and laboratory data were time-referenced to the days on treatment with a particular binder. Patients were followed until discontinuation of the phosphorus binder, death, transplant, transfer to another dialysis provider or censoring at 36 months after medication was started.

Results::

Compared to calcium acetate and sevelamer, ferric citrate utilisation in PD patients resulted in a sustained increase in ferritin. The proportion of patients with a ferritin equal to or greater than 800 ng/dL and transferrin saturation greater than 40% increased over time in patients treated with ferric citrate and was higher during the second and third year of follow-up compared to baseline values and to patients treated with calcium acetate or sevelamer. Two patients (7%) treated with ferric citrate developed clinically significant haemosiderosis.

Conclusions::

Use of ferric citrated in PD resulted in significant iron accumulation as judged by ferritin levels.

01 Feb 2024·Chemosphere

Formulation of PG-FA-L composite modifier for repairing expansive soil based on the statistical mixed design method

Article

Author: Qin, Lin ; Li, Jie ; Chu, ChengFu ; Kang, Bo ; Hu, ChuanQing ; Zha, Fusheng

The generation of large amounts of solid waste has led to exploration of solid waste-modified expansive soils; however, the effect of a single solid waste-modified expansive soil is not ideal. This study proposes a composite modification of expansive soils using a PG-FA-L system. Statistical analysis showed that the properties of the cured soil were significantly improved. PG and FA increased soil strength after a certain threshold, and L increased it at all stages. The presence of PG accelerated the volcanic ash reaction. Both PG and FA have a small effect on the swelling of the soil, whereas lime improves it significantly, but has a negative effect after a certain threshold. The 28-day unconfined compressive strength and deformation characteristics were used to derive the relevant regions for roadbed fill requirements and determine the optimum dosage.

01 Jan 2024·Phytomedicine : international journal of phytotherapy and phytopharmacology

Phytocompounds from essential oil of Mentha aquatica L. cv. Lime prevent vemurafenib-promoted skin carcinogenesis via inhibiting HRAS keratinocytes and reprogramming macrophage activities

Article

Author: Chang, Chih-Ting ; Shyur, Lie-Fen ; Chen, Yu-Hsin

BACKGROUND:

Twenty to thirty percent of patients taking BRAF inhibitors such as vemurafenib (PLX4032) for melanoma develop cutaneous squamous cell carcinomas.

PURPOSE:

This study aimed to elucidate the chemopreventive effect of essential oil from Mentha aquatica L. cv. Lime (EO) and its major constituents, limonene and carvone (L + C) that made up 45.68% of the EO, against PLX4032-induced cutaneous side effects.

METHODS:

PLX4032 accelerated skin papilloma formation and keratinocyte HRAS mutation in 7,12-dimethylbenz[a]anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)-induced two-stage skin carcinogenesis mouse model was used to evaluate the in vivo bioefficacy of EO and L + C. The effects and molecular mechanisms of EO and L + C on deregulating mouse PDV^HRASQ61L keratinocyte activities were demonstrated using a spectrum of bioactivity assays, western blotting, immunochemistry, and keratinocyte-macrophage co-culture assay.

RESULTS:

Treatment with EO suppressed colony formation ability, cell migration, invasion, and induced G₂/M cell-cycle arrest and apoptosis in PDV^HRASQ61L keratinocytes, and L + C treatment inhibited colony formation, cell migration and invasion of PDV cells. In mouse skin irritated with DMBA/TPA (DT group) or DMBA/TPA with PLX4032 (DTP group), topical application of EO and L + C significantly delayed papilloma appearance and reduced papilloma incidence compared to DT or DTP controls. Histopathology results showed that EO and L + C treatment attenuated K14⁺ keratinocyte proliferation and paradoxical MAPK activation, and shifted the macrophage population from M2 (CD163⁺) to M1 (iNOS⁺) in the mouse skin microenvironment. The conditioned medium of EO or L + C pre-treated PDV keratinocytes promoted M₀ macrophages to differentiate from THP-1 cells into M1-like macrophages.

CONCLUSION:

This study demonstrates that EO and L + C in combination prevent PLX4032-induced cutaneous side-effects and skin carcinogenesis in mice through reprogramming the macrophage cell population and inhibiting keratinocyte activity. Both mint EO and the natural products L + C can be considered to be effective chemopreventive agents that might be useful in reducing cutaneous lesions in human patients administrated with BRAF inhibitors.

News (Medical) associated with Calcium Acetate

30 Nov 2023

·www.prnewswire.com

Astral Tequila and The Sculpt Society Unite to Launch the 'Good Energy Movement' Nationwide

Created in collaboration with fitness trainer and Founder of The Sculpt Society, Megan Roup, the two brands are brightening the holiday season and ushering in the New Year through the power of movement and connection. NEW YORK, Nov. 30, 2023 /PRNewswire/ -- As we enter the holiday season and prepare to welcome the New Year, Astral Tequila and The Sculpt Society are joining forces to ignite a 'Good Energy Movement.' It's proven important to embrace a positive mindset in the winter months, according to a study by the International Journal of Wellbeing1, and with the days getting shorter and the weather turning colder, it's a vital time to foster connections, continue to uplift one another, and keep the good energy circulating well into 2024. Continue Reading Astral Tequila and The Sculpt Society unite to launch the ‘Good Energy Movement’ nationwide, harnessing and spreading the power of positive energy through movement and connection. Experience the full interactive Multichannel News Release here: Created in partnership with fitness trainer and The Sculpt Society Founder, Megan Roup, the 'Good Energy Movement' offers a variety of virtual and in-person experiences to make spreading good energy more accessible. Participants wanting to get into a positive mindset can join in with 'Good Energy Movement' workouts, Astral Tequila get-togethers organized for moments of connection, and an exclusive holiday cocktail kit that serves as the perfect gift that gives back. Through these elements, the 'Good Energy Movement' aims to harness and spread the power of positive energy to your inner circle and beyond. "At Astral Tequila, spreading good energy is at the heart of everything we do, from harnessing the energy of the sun to grow our agave, to upcycling our spent agave fibers into adobe bricks used to build homes for people in Mexico," says Christina Choi, Senior Vice President of Tequila, Diageo North America. "With The Sculpt Society, we've found a like-minded partner who shares our passion for spreading positivity and connection." The series of 'Good Energy Movement' in-person sessions featuring workouts and post-workout Astral Tequila get-togethers are available exclusively through The Sculpt Society App and popping up in Dallas, Texas, and Charleston, South Carolina. If you're participating virtually from home, you can treat yourself and your loved ones (must be 21+) to a limited-edition 'Good Energy Movement' kit, featuring Megan's picks for creating a good energy oasis for you and your inner circle. In the spirit of giving back, the kit includes a one-month subscription to The Sculpt Society for you and one to gift a friend, a limited-edition co-branded exercise ball, ideal for your 'Good Energy Movement' workouts, and all the ingredients needed to make Megan's Mistletoe Margarita, featuring a winter twist on the classic cocktail. The kit is available starting today through December 30th for consumers 21+ on Cocktailcourier.com/product/astral-x-tss for an SRP of $69.99 while supplies last. "The 'Good Energy Movement' is all about coming together and sharing positive energy, and I'm thrilled to partner with Astral Tequila to make this happen," said Megan Roup, Founder of The Sculpt Society. "Through movement, connection, and some fantastic cocktails, we aim to bring people together during this time of year." Check out Astral Tequila and The Sculpt Society's Instagram pages for updates all season long and become part of the 'Good Energy Movement.' And as you do, please remember to enjoy Astral Tequila responsibly. Make Megan's favorite Astral Tequila recipe at home! Mistletoe Margarita 1.5oz Astral Tequila Blanco 0.75oz Lime Juice 0.75oz Pomegranate Juice 0.5oz Agave Garnish: Toasted Rosemary Instructions: Combine all ingredients in a cocktail shaker, add ice, shake and strain into an ice-filled rocks glass. Garnish with a sprig of toasted rosemary. About Astral Tequila Astral Tequila is a super-premium tequila crafted using 100% Blue Weber agave nourished by the sun and stars in Jalisco, Mexico. Using a tahona and bagazo during fermentation, Astral Tequila's unique recipe uses traditional, time-intensive processes to create a radiant tequila that brightens every cocktail. Each bottle of Astral Tequila produced helps continue the circular flow of good energy – leftover agave fibers are upcycled into adobe bricks to be used to construct buildings in local communities in Mexico to create more places to gather with loved ones and feel connected. Astral Tequila launched in April 2021 with its first expression, Blanco, followed by Reposado and Añejo in April 2023. For more information on Astral Tequila, please visit . About The Sculpt Society The Sculpt Society is the #1 Sculpt and Dance Cardio workout designed to empower women through movement. Created by celebrity trainer Megan Roup, The Sculpt Society app offers fun and effective low-impact sculpt workouts to tone your entire body, easy-to-follow dance cardio classes + yoga, stretch and meditation videos. With 600+ on-demand workouts, weekly live classes and guided programs, The Sculpt Society's results-driven fitness method will help you see and feel the difference. 1 Journal of Wellbeing Study SOURCE Diageo North America

18 Jan 2023

·www.prnewswire.com

Worldwide Essential Oils Industry to 2027 - Increase in Demand for Aromatherapy Drives Growth

DUBLIN, Jan. 18, 2023 /PRNewswire/ -- The "Essential Oils Market By Product Type, Application (Food & beverages, Cosmetics & Toiletries, Aromatherapy, Home Care, and Health Care), Source (Fruits & Vegetables, Herbs & Spices, Flowers), Method of Extraction and Region - Global Forecast to 2027" report has been added to ResearchAndMarkets.com's offering. The global essential oils market size is estimated to be valued at USD 8.8 billion in 2022 and is projected to reach USD 15.3 billion by 2027, recording a CAGR of 11.8% in terms of value. By application, the aromatherapy is projected to grow rapidly during the forecast period The rising popularity of aromatherapy and other alternative medicine is increasing in demand, as are the relaxing effects of essential oils when applied through a massage. The health industry has begun to incorporate essential oils in aromatherapy applications to treat Alzheimer's, bronchitis, and various cardiovascular problems. Changing lifestyles and their consequences, such as high stress and depression, along with increasing disposable incomes, results in an increase in demand for aromatherapy. Ginger oil, pine oil, oregano oil, and wintergreen oil are some of the essential oils used on a large scale in alternative therapies. The National Association for Holistic Aromatherapy (NAHA), the Alliance of International Aroma Therapists, and The Canadian Federation of Aroma Therapists have established standards for aromatherapy certification in the US and Canada. This would allow the essential oil industry to use different oils for various aromatherapy products, globally. By type, the orange essential oil is widely used in all the domains due to the presence of the high amount of vitamin C and appealing fragrance Oranges are full of vitamin C and offer several health advantages. The rind of the sweet orange, Citrus sinensis, is used to make orange essential oil. Cold pressing, a technique used to extract the oils from the rind, is used to accomplish this. Brazil is the leading orange producer in the world producing about 30% of the world's output. Orange oil, which is energetic, is one of the most widely used options in aromatherapy. The oil can decrease various kinds of pain such as inflammation, muscle spasms, tissue damage, pain from bone fractures, headache, etc. The Asia Pacific market is being driven by an increase in demand for domestic products brought on by an expanding middle class The Asia Pacific region is mostly segmented into India, China, Japan, New Zealand, Australia, and Rest of Asia pacific. The improving standard of living and high per capita income in the region, along with higher expenditure, are driving up the demand for essential oils, which has been significantly influenced by the growth of the wellness and leisure sectors. The demand for citrus-based essential oils like orange and lemon has also attracted a lot of consumer interest in some of nations. The product is becoming more widely used in the personal care and household products sectors, and the usage of citrus essential oil in tastes, odorants, and pharmaceutical substances has lately increased. With emerging economies, growing industrialization, increasing demand for processed foods, and consumer preference for quality products, ingredient suppliers are becoming increasingly optimistic about the growth of the food & beverage industry. Key Topics Covered: 1 Introduction 2 Research Methodology 3 Executive Summary 4 Premium Insights 4.1 Attractive Opportunities for Players in Essential Oil Market 4.2 Essential Oils Market: Major Regional Submarkets 4.3 Asia-Pacific: Essential Oil Market, by Source & Country 4.4 Asia-Pacific: Essential Oil Market, by Application 4.5 Essential Oil Market, by Methods of Extraction 4.6 Essential Oil Market, by Application & Region 5 Market Overview 5.1 Introduction 5.2 Macroeconomic Indicators 5.2.1 Rise in Depression and Anxiety Disorders 5.2.2 Increasing Demand for Organic Food 5.3 Market Dynamics 5.3.1 Drivers 5.3.1.1 Increase in Demand for Aromatherapy 5.3.1.2 Increasing Demand for Natural Ingredients and Clean Label Products 5.3.1.3 Increased Use of Essential Oils in Homecare Products 5.3.1.4 Use of Essential Oils as an Additive in Feed 5.3.1.5 Demand for Essential Oils in Cosmetic & Fragrance Industry 5.3.2 Restraints 5.3.2.1 Depletion of Natural Resources 5.3.2.2 Side Effects Associated with Specific Essential Oils 5.3.3 Opportunities 5.3.3.1 Powdered Essential Oil to Create New Opportunities 5.3.4 Challenges 5.3.4.1 Prevalence of Synthetic/Adulterated Products 6 Industry Trends 6.1 Introduction 6.2 Value Chain 6.2.1 Research and Product Development 6.2.2 Raw Material Sourcing 6.2.3 Production 6.2.4 Packaging, Storage, and Distribution 6.2.5 End-Users 6.3 Supply Chain Analysis 6.4 Market Map and Ecosystem of Essential Oils Market 6.4.1 Demand Side 6.4.2 Supply Side 6.4.3 Ecosystem Map 6.5 Trends/Disruptions Impacting Customers' Businesses 6.5.1 Revenue Shift and New Revenue Pockets in Essential Oil Market 6.6 Technology Analysis 6.6.1 Ultrasonic Hydro Distillation 6.6.2 Pressurized Hot Water Extraction 6.6.3 Drying Technology 6.6.4 Encapsulation 6.7 Pricing Analysis 6.7.1 Selling Prices Charged by Key Players in Terms of Application 6.8 Essential Oils Market: Patent Analysis 6.8.1 List of Major Patents 6.9 Trade Analysis: Essential Oil Market 6.9.1 Export Scenario: Essential Oils for Citrus Fruits 6.9.2 Import Scenario: Citrus Fruit Essential Oils 6.9.3 Export Scenario: Essential Oils 6.9.4 Import Scenario: Essential Oils 6.10 Case Studies: Essential Oil Market 6.10.1 Rocky Mountain Oils: Sustainable Packaging 6.10.2 Doterra: Increase Operations Efficiency 6.11 Key Conferences and Events, 2022-2023 6.12 Tariff and Regulatory Landscape 6.12.1 Regulatory Bodies, Government Agencies, and Other Organizations 6.13 Porter's Five Forces Analysis 6.14 Key Stakeholders and Buying Criteria 7 Essential Oils Market, by Type 7.1 Introduction 7.2 Orange Oil 7.2.1 Increased Use in Aromatherapy 7.3 Peppermint Oil 7.3.1 Europe and Asia-Pacific to Have Significant Impact on Market 7.4 Lemon Oil 7.4.1 Rise in Demand for Nutraceuticals with Natural Flavor 7.5 Lavender Oil 7.5.1 Improves Skin Health 7.6 Lime Oil 7.6.1 Effective for Skin Infection Treatments 7.7 Rosemary Oil 7.7.1 Increased Usage in Healthcare Products due to Antioxidant Properties 7.8 Cornmint Oil 7.8.1 Powerful Antibacterial and Antiseptic Oil 7.9 Spearmint Oil 7.9.1 Extensively Used in Food & Beverage Industry as Flavoring Ingredient 7.10 Geranium Oil 7.10.1 Primary Floral Component in Fragrance and Cosmetics 7.11 Clove Leaf Oil 7.11.1 Used for Oral Health due to Germicidal Properties 7.12 Rose Oil 7.12.1 Widely Used in Aromatherapy 7.13 Coriander Oil 7.13.1 Use in Seasonings due to Flavoring Properties 7.14 Tea Tree Oil 7.14.1 Therapeutic Benefits to Increase Demand in Skincare and Cosmetics Industry 7.15 Citronella Oil 7.15.1 Large-Scale Use in Aromatherapy to Treat Migraine and Headaches 7.16 Eucalyptus Oil 7.16.1 High Demand in Dental Care due to Germicidal Properties 7.17 Jasmine Oil 7.17.1 Extensively Used for Health Benefits 7.18 Other Types 8 Essential Oils Market, by Method of Extraction 8.1 Introduction 8.2 Distillation 8.2.1 Steam Distillation Method Used Extensively to Obtain Essential Oils Economically 8.3 Cold Press Extraction 8.3.1 Citrus Fruits Extracted Via Cold Press 8.4 Carbon Dioxide Extraction 8.4.1 Aroma and Bioactive Components of Essential Oils Effectively Retained 8.5 Other Extractions 9 Essential Oils Market, by Source 9.1 Introduction 9.2 Fruits & Vegetables 9.2.1 Cold Press Method Preferred for Essential Oil Extraction from Fruits and Vegetable 9.3 Flowers 9.3.1 Essential Oils Represent an Upstream Business Opportunity for Floriculture Market 9.4 Herbs & Spices 9.4.1 Herb-Derived Essential Oils as Natural Replacers of Compounds of Synthetic Origin 10 Essential Oils Market, by Application 10.1 Introduction 10.2 Food & Beverages 10.2.1 Extensive Use of Citrus Essential Oils in Food & Beverage Industry 10.3 Cosmetics & Toiletries 10.3.1 Extensive Use of Essential Oils due to Fragrance and Functional Properties 10.4 Aromatherapy 10.4.1 Therapeutic Potential of Essential Oils 10.5 Homecare 10.5.1 Demand for Natural Ingredients to Boost Demand 10.6 Healthcare 10.6.1 Mental Well-Being to Drive Healthcare Industry 10.7 Other Applications 11 Essential Oils Market, by Region 12 Competitive Landscape 12.1 Overview 12.2 Market Share Analysis, 2021 12.3 Segmental Revenue Analysis of Key Players 12.4 Key Player Strategies 12.5 Company Evaluation Quadrant (Key Players) 12.5.1 Stars 12.5.2 Emerging Leaders 12.5.3 Pervasive Players 12.5.4 Participants 12.5.5 Product Footprint 12.6 Essential Oils Market, Evaluation Quadrant for Start-Ups/Smes, 2021 12.6.1 Progressive Companies 12.6.2 Starting Blocks 12.6.3 Responsive Companies 12.6.4 Dynamic Companies 12.6.5 Competitive Benchmarking of Key Start-Ups/Smes 12.7 Competitive Scenario 12.7.1 New Product Launches 12.7.2 Deals 12.7.3 Others 13 Company Profiles 13.1 Introduction 13.2 Key Player 13.2.1 Dsm 13.2.2 Givaudan 13.2.3 International Flavors & Fragrances Inc. (Iff) 13.2.4 Sensient Technologies Corporation 13.2.5 Cargill, Incorporated 13.2.6 Symrise 13.2.7 Robertet, Sa 13.2.8 Mane 13.2.9 Doterra 13.2.10 Now Foods 13.2.11 Synthite Industries Ltd. 13.2.12 Lebermuth, Inc. 13.2.13 Biolandes 13.2.14 Norex Flavours Private Limited 13.2.15 India Essential Oils 13.3 Other Players (Smes/Start-Ups) 13.3.1 Falcon 13.3.2 Farotti S.R.L. 13.3.3 Vidya Herbs 13.3.4 Young Living Essential Oils, Lc. 13.3.5 Essential Oils of New Zealand Ltd. 13.3.6 Veda Oils 13.3.7 Hcp Wellness 13.3.8 Vital Herbs 13.3.9 Cv Rasayana Wangi 13.3.10 Alchemy Chemicals 14 Adjacent & Related Markets 15 Appendix For more information about this report visit Media Contact: Research and Markets Laura Wood, Senior Manager [email protected] For E.S.T Office Hours Call +1-917-300-0470 For U.S./CAN Toll Free Call +1-800-526-8630 For GMT Office Hours Call +353-1-416-8900 U.S. Fax: 646-607-1907 Fax (outside U.S.): +353-1-481-1716 Logo: SOURCE Research and Markets

100 Deals associated with Calcium Acetate

External Link

KEGG	Wiki	ATC	Drug Bank
D00931	Calcium Acetate	V03AE07	DB00258

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Kidney Failure, Chronic	US	Fresenius Medical Care North America Holdings LP	02 Apr 2001
Hyperphosphatemia	US	Fresenius Medical Care North America Holdings LP	10 Dec 1990

Developing

10 top R&D records.

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Chronic Kidney Diseases	Phase 3	US	Nabi Biopharmaceuticals	01 May 2005

Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT01135615 (Pubmed \| Am J Kidney Dis)	Phase 4	Chronic Kidney Diseases	100	Sevelamer	tfcwuanoec(dqwxaxgzxg) = rqspjsmabg ypvwgjxskn (cvgjssowxj )	-	01 Feb 2012
				Calcium Acetate	tfcwuanoec(dqwxaxgzxg) = pfaohlnkhs ypvwgjxskn (cvgjssowxj )
NCT00211978 (Pubmed \| BMC Nephrol)	Phase 3	Chronic Kidney Diseases	110	Calcium acetate	xrqfjntggt(mpmzokwcqo) = rgmibbaaxz gzlyoojeny (ubpqldpdbm )	Positive	16 Feb 2011
				Placebo	xrqfjntggt(mpmzokwcqo) = edhqariuuu gzlyoojeny (ubpqldpdbm )
CARE trial (ASN2010)	Not Applicable	Chronic Kidney Disease-Mineral and Bone Disorder \| Chronic Kidney Diseases FGF23 levels	-	Vehicle	mlcedkhzxk(fzzcwarkws) = norbpohlkh rshwhiicfm (hquowzuwok )	-	16 Nov 2010
				Calcium Acetate 1%	mlcedkhzxk(fzzcwarkws) = ooglxdezbc rshwhiicfm (hquowzuwok )

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