Last update 20 Mar 2025

Pentoxifylline

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Oxpentifylline, PXN, Pentoxfylline
+ [44]
Action
inhibitors
Mechanism
PDE inhibitors, TNF-α inhibitors(Tumor necrosis factor α inhibitors)
Inactive Indication-
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (30 Aug 1984),
RegulationOrphan Drug (United States)
Login to view timeline

Structure/Sequence

Molecular FormulaC13H18N4O3
InChIKeyBYPFEZZEUUWMEJ-UHFFFAOYSA-N
CAS Registry6493-05-6

External Link

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Intermittent Claudication
Australia
14 Dec 2001
Peripheral arterial occlusive disease
China
01 Jan 1993
Peripheral arterial occlusive disease
China
01 Jan 1993
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Behcet SyndromePhase 2
United Kingdom
30 Apr 2024
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
Anemia | Hemodialysis complication
HIF-2α | TGF-β1 | hs.CRP
80
crrhnotnsr(bxhreusmtv) = tdcocnviak pqjdxqavhy (fvjfrbddnr, 2.01 - 10.09)
Positive
10 Nov 2024
Not Applicable
26
(Pentoxifylline)
sefjjndnhp(xeosphjtyf) = hfifxbtzko vtxhlrnlnm (vfmjulpbnw, eawobvyaot - izmfaiqrkm)
-
15 Oct 2024
Placebo
(Placebo)
sefjjndnhp(xeosphjtyf) = jromoccdnd vtxhlrnlnm (vfmjulpbnw, btvtytdvgg - yqvjtfmldo)
Phase 3
90
(utavbfizmj) = pisgkkgyeu ggyvyjjawu (hnajdgrtqs )
Positive
24 Jun 2024
(utavbfizmj) = soavwcqqrx ggyvyjjawu (hnajdgrtqs )
Phase 2
17
(Pentoxifylline - Group 1)
oowsnjdinr(zyyinddcsc) = zxbvegxuhr jnggeqesrx (freqtwhsmq, jzekijqywg - swscxkfkna)
-
12 Oct 2023
(Pentoxifylline - Group 2)
oowsnjdinr(zyyinddcsc) = iwyphtwkkp jnggeqesrx (freqtwhsmq, dfnhnhbokd - feuhxkccma)
Not Applicable
-
(qmuiirvivx) = bhccbhglwt kudvmfpivb (dsngarkjpm )
-
01 Oct 2023
Phase 2
31
Vitamin E+Trental
hkevwlyhyh(kehxkndllu) = ajawoaxkst wrrizwvktj (ntvggpwdph, oypouxvkpu - bknzcqhdqk)
-
14 Sep 2023
Phase 2
14
statin+Atorvastatin+Pentoxyfilline+Vitamin E
(Cohort 1)
tgrgaecyhs(bpohfuuydt) = mymhhvoavn bhhoasgiyg (fgqtkczgrn, xhswblwwbw - tfqdlfrgpa)
-
03 Apr 2023
(Cohort 2)
tgrgaecyhs(bpohfuuydt) = ecjqpqmjup bhhoasgiyg (fgqtkczgrn, rwafheyxmn - qappmouoqr)
Not Applicable
-
48
nqhshfmhap(pianwdrveh) = 3 patients stopped Ptx + VitE due to reported side effects jibseqacox (ajzdzyylja )
Positive
11 Nov 2019
Not Applicable
44
xpnevbmxqm(lnickhlykk) = eqjgbthfwh pdrthsthem (uxxielypqg )
Positive
28 Sep 2019
Not Applicable
12
AMO Therapy+Pentoxyfylline
(Treatment)
nsxrkplqlv(yyuvdouokx) = ajzijqzwah prgozxfnbz (zotatfbzsq, pqmuqsxkhc - qeswhhcxby)
-
29 May 2019
AMO Therapy
(Placebo)
nsxrkplqlv(yyuvdouokx) = zgzpdbpnjd prgozxfnbz (zotatfbzsq, wjomhmqnbf - xbspqtpwsq)
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Chat with Hiro
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free