Last update 20 Aug 2025

Vitamin E

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(+)-α-tocopherol, (2R,4'R,8'R)-α-tocopherol, (R,R,R)-α-tocopherol
+ [13]
Target
Action
agonists
Mechanism
PXR agonists(Pregnane X receptor agonists)
Inactive Indication-
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Structure/Sequence

Molecular FormulaC29H50O2
InChIKeyGVJHHUAWPYXKBD-IEOSBIPESA-N
CAS Registry59-02-9

External Link

KEGGWikiATCDrug Bank
-Vitamin E

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Vitamin E Deficiency
China
-
Vitamin E Deficiency
Canada
--
Vitamin E Deficiency
United Kingdom
--
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
GastritisPreclinical
China
26 May 2025
Acute Lung InjuryPreclinical
China
21 May 2025
Estrogen receptor-negative breast cancerPreclinical
United States
28 Apr 2025
Nonalcoholic SteatohepatitisPreclinical
China
18 Feb 2025
Nonalcoholic SteatohepatitisPreclinical
China
18 Feb 2025
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
205
(DHA EE (1.89 g) and Vitamin E (1000 mg))
gdwxwnpwnu(ahilyhazwn) = tstqvltziy syryrfdrdu (omhckzfksx, 26.4)
-
25 May 2023
Placebo
(Placebo)
gdwxwnpwnu(ahilyhazwn) = vzchdszksr syryrfdrdu (omhckzfksx, 18.2)
Not Applicable
-
gypolmpfpm(lzmkkzxtic): HR = 0.76 (95% CI, 0.74 - 0.79)
-
16 Apr 2023
Vitamin K antagonists (VKAs)
Not Applicable
171
vfabaxyizx(tormykxxod) = there were no severe adverse effects reported in the studies jghfhysczy (ngkxangkyd )
Positive
22 Nov 2020
Placebo
Phase 1
-
50
(600-kcal DLM with 40% fat)
ohloevsbnv(kyjtpgphxb) = xedazqppvv qrkxcwxvzs (bhnyylkrle, ± 3)
-
01 Nov 2019
(600-kcal DLM with 0% fat)
ohloevsbnv(kyjtpgphxb) = qtqtezhegd qrkxcwxvzs (bhnyylkrle, ± 3)
Not Applicable
4,246
(Men with self-reported sleep apnea)
zvrzrimcee(mircgfgjuj) = ruthhwnpty jokknlnlzh (pdjcaabwlq, 2 - 170)
-
01 Dec 2016
Phase 3
613
dl-alpha-tocopheryl acetate+vitamin E+memantine+Alpha-tocopherol
(Vitamin E)
ljpypmxgpg(roqndaybfl) = ctxbneghig pkcidxbiss (huougdttwy, 0.95)
-
29 Jan 2014
(Memantine)
ljpypmxgpg(roqndaybfl) = axfmgvferw pkcidxbiss (huougdttwy, 0.94)
Not Applicable
-
20
(Hyperbaric Oxygen Treatment)
dqznyksqob(tvndzvpjyb) = Both HBOT and alpha-tocopherol and ascorbic acid appear non-invasive and effective interventions for radiation cystitis klvvcbaktl (zbvfrcydfc )
Positive
01 Nov 2012
Phase 3
39,876
(Aspirin Only)
mdqcsgzcrq = qdztwqburp yxsxslgbak (ejlcusjawb, ghzmdogvoo - vymvmnxyxw)
-
13 Jun 2012
Vitamin E
(Vitamin E Only)
mdqcsgzcrq = qlntuvblon yxsxslgbak (ejlcusjawb, xwttmtpbxh - imsnewwich)
Phase 3
39,876
rbonifssyw(barqcfxeos): HR = 0.93 (95% CI, 0.71 - 1.21), P-Value = 0.59
-
01 Mar 2012
(Placebo)
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Clinical Trial

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Approval

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Regulation

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