Last update 14 Jun 2025

Numidargistat

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
CB-1158, INCB 001158, INCB 01158
+ [2]
Target
Action
inhibitors
Mechanism
ARG1 inhibitors(Arginase-1 inhibitors)
Active Indication-
Originator Organization
Active Organization-
Drug Highest PhaseDiscontinuedPhase 1/2
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC18H27BCl2N2O4
InChIKeyISYBHIALKUAHGV-UHFFFAOYSA-N
CAS Registry1345810-21-0

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Refractory Multiple MyelomaPhase 2
United States
25 Sep 2019
Refractory Multiple MyelomaPhase 2
Germany
25 Sep 2019
Refractory Multiple MyelomaPhase 2
Spain
25 Sep 2019
Relapse multiple myelomaPhase 2
United States
25 Sep 2019
Relapse multiple myelomaPhase 2
Germany
25 Sep 2019
Relapse multiple myelomaPhase 2
Spain
25 Sep 2019
Advanced Malignant Solid NeoplasmPhase 2
United States
21 Nov 2017
Advanced Malignant Solid NeoplasmPhase 2
Belgium
21 Nov 2017
Advanced Malignant Solid NeoplasmPhase 2
United Kingdom
21 Nov 2017
Biliary Tract NeoplasmsPhase 2
United States
21 Nov 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
-
ilpyljumzg(tsewkpfwwq) = n=24/147 (16.3%) with combination therapy xgfejfeyln (czdvuxjbcd )
Negative
01 May 2024
Phase 1/2
15
(Phase 1: INCB001158 75 mg BID + Daratumumab)
mhnzkrrmxo = qpqwqbtnrf lcwdtbqcrf (tjghnatqsu, kyejmjdwpk - gbowmganaj)
-
20 Mar 2023
(Phase 1: INCB001158 100 mg BID + Daratumumab)
mhnzkrrmxo = yrgwprzlcf lcwdtbqcrf (tjghnatqsu, heasduztib - mzecbvpauf)
Phase 1/2
33
(phase II)
onwtthtzic(rlmnjligvo) = yazfoskucs yvhcedaddu (dljkxrjhzs, 11.1 - 42.3)
Positive
20 Jan 2021
Phase 1/2
5
(INCB001158 50mg BID+ Epacadostat + Pembrolizumab)
zgavfyxwrx(ellbwohksl) = podfpnwdxr ornkfjrqdl (ldikfntxtu, vfveqrcbpx - jcvkgmzupo)
-
21 May 2020
(INCB001158 75 mg BID + Epacadostat + Pembrolizumab)
zgavfyxwrx(ellbwohksl) = whkeiqgfcv ornkfjrqdl (ldikfntxtu, odoqtumfzv - nqyltddkfh)
Phase 1
73
rxscqayrsz(sqdddhqyfl) = 100 mg BID uvsrbikfrh (fjyqvkszde )
Positive
29 Sep 2019
(monotherapy)
Not Applicable
-
yhdnfcxxpo(cdyvcdefzh) = kopnmeszmp userswxapw (pyhewerkbj )
-
16 Nov 2016
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Core Patent

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Clinical Trial

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Approval

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Regulation

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