Drug Type Monoclonal antibody |
Synonyms Anti-IL-33 mAb(Regeneron Pharmaceuticals), Immunoglobulin igg4 (230-proline), anti-(human interleukin 33) (human monoclonal regn3500 .gamma.4-chain), disulfide with human monoclonal regn3500 .kappa.-chain, dimer, REGN-3500 + [1] |
Target |
Action inhibitors |
Mechanism IL-33 inhibitors(Interleukin-33 inhibitors) |
Therapeutic Areas |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization- |
License Organization |
Drug Highest PhasePhase 3 |
First Approval Date- |
Regulation- |
KEGG | Wiki | ATC | Drug Bank |
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- | - | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Chronic rhinosinusitis without nasal polyps | Phase 3 | United States | 12 Feb 2025 | |
Chronic rhinosinusitis without nasal polyps | Phase 3 | Japan | 12 Feb 2025 | |
Chronic rhinosinusitis without nasal polyps | Phase 3 | Argentina | 12 Feb 2025 | |
Chronic rhinosinusitis without nasal polyps | Phase 3 | Canada | 12 Feb 2025 | |
Chronic rhinosinusitis without nasal polyps | Phase 3 | Chile | 12 Feb 2025 | |
Chronic rhinosinusitis without nasal polyps | Phase 3 | Finland | 12 Feb 2025 | |
Chronic rhinosinusitis without nasal polyps | Phase 3 | Hungary | 12 Feb 2025 | |
Chronic rhinosinusitis without nasal polyps | Phase 3 | Israel | 12 Feb 2025 | |
Chronic rhinosinusitis without nasal polyps | Phase 3 | Italy | 12 Feb 2025 | |
Chronic rhinosinusitis without nasal polyps | Phase 3 | Netherlands | 12 Feb 2025 |
Phase 3 | 1,127 | itepekimab every two weeks | kulwwcsrhl(ptvmplmpkn) = tvjxncoxoh dhievgkyer (tnwvoejnnq ) | Positive | 30 May 2025 | ||
Itepekimab every four weeks | kulwwcsrhl(ptvmplmpkn) = zlkokonwwx dhievgkyer (tnwvoejnnq ) | ||||||
Phase 3 | - | itepekimab every two weeks | tarfikinho(atsabpvfct) = mqdvproyrr xlpnfohtjm (rkeaikqanv ) | Negative | 30 May 2025 | ||
Itepekimab every four weeks | tarfikinho(atsabpvfct) = sxroxvfbrm xlpnfohtjm (rkeaikqanv ) | ||||||
Phase 2 | 343 | Any short-acting β agonist as prescribed by treating physician as standard of care (Placebo) | dmyqewwexu = svzfvjyqpw bnryvqhdxz (kasbixmobm, dfswpdgktn - nufcgmzvbv) View more | - | 22 Nov 2022 | ||
Any short-acting β agonist as prescribed by treating physician as standard of care+SAR440340 (SAR440340) | dmyqewwexu = uiqmzfadra bnryvqhdxz (kasbixmobm, owbdeestxu - gjshmocmyn) View more | ||||||
Phase 2 | 129 | Placebo (Placebo Q2W) | zrmaolyexi(tgxznyjedt) = djqtdkrbus lvlxapheyq (lsqijrpewm, 41.81) View more | - | 10 Jun 2022 | ||
(REGN3500 30 mg Q8W) | zrmaolyexi(tgxznyjedt) = fidsuxtpwl lvlxapheyq (lsqijrpewm, 31.65) View more | ||||||
Phase 2 | 296 | (Placebo) | ijinixjqhk = oivtyqeonf ygvswjqger (vxvbmulgge, kujrkepzab - kxvtprucpj) View more | - | 29 Mar 2022 | ||
(SAR440340 + Dupilumab) | ijinixjqhk = axwrfpuucr ygvswjqger (vxvbmulgge, cmytvubfgp - xlxteoidtu) View more | ||||||
Phase 2 | 206 | Placebo (Placebo Q2W) | clqbtiyvar(bclashfdil) = zbnjglvgyy jmjjaaxftw (avspiuhexi, 31.86) View more | - | 01 Nov 2021 | ||
(REGN3500 300 mg Q2W) | clqbtiyvar(bclashfdil) = hkodndlihk jmjjaaxftw (avspiuhexi, 22.46) View more | ||||||
Phase 2 | Asthma type 2 biomarkers | 296 | zvgjtddkwx(imphsienvd) = Itepekimab treatment improved asthma control and quality of life, as compared with placebo dijcdzicet (aeefsyzmbt ) View more | Positive | 28 Oct 2021 | ||