Last update 29 Mar 2025

Itepekimab

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
Anti-IL-33 mAb(Regeneron Pharmaceuticals), Immunoglobulin igg4 (230-proline), anti-(human interleukin 33) (human monoclonal regn3500 .gamma.4-chain), disulfide with human monoclonal regn3500 .kappa.-chain, dimer, REGN-3500
+ [1]
Target
Action
inhibitors
Mechanism
IL-33 inhibitors(Interleukin-33 inhibitors)
Inactive Indication
Originator Organization
Inactive Organization
Drug Highest PhasePhase 3
First Approval Date-
Regulation-
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Structure/Sequence

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Chronic rhinosinusitis without nasal polypsPhase 3
United States
12 Feb 2025
Chronic rhinosinusitis without nasal polypsPhase 3
United Kingdom
12 Feb 2025
Chronic rhinosinusitis with nasal polypsPhase 3
United States
06 Feb 2025
Chronic rhinosinusitis with nasal polypsPhase 3
China
06 Feb 2025
Chronic rhinosinusitis with nasal polypsPhase 3
Australia
06 Feb 2025
Chronic rhinosinusitis with nasal polypsPhase 3
United Kingdom
06 Feb 2025
Moderate chronic obstructive pulmonary diseasePhase 3
United States
16 Dec 2020
Moderate chronic obstructive pulmonary diseasePhase 3
United States
16 Dec 2020
Moderate chronic obstructive pulmonary diseasePhase 3
United States
16 Dec 2020
Moderate chronic obstructive pulmonary diseasePhase 3
Argentina
16 Dec 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
343
Any short-acting β agonist as prescribed by treating physician as standard of care
(Placebo)
grmruqpzlp = isjlsrfipl rkuobropfv (xebodusbxb, whtvdutmyv - axhiyplumz)
-
22 Nov 2022
Any short-acting β agonist as prescribed by treating physician as standard of care+SAR440340
(SAR440340)
grmruqpzlp = ozmvwldsaq rkuobropfv (xebodusbxb, ortnvfrfba - agzsamgugm)
Phase 2
129
Placebo
(Placebo Q2W)
qmbdrmnotk(kktghrtmfu) = xtqlvuyadb qoywazjxvt (eakmdwddqp, 41.81)
-
10 Jun 2022
(REGN3500 30 mg Q8W)
qmbdrmnotk(kktghrtmfu) = dhrbafxjog qoywazjxvt (eakmdwddqp, 31.65)
Phase 2
296
Placebo for dupilumab+Fluticasone+Fluticasone/salmeterol
(Placebo)
fwfuwuxrmn = ypyjdnevfj wdertohxpn (byvnqdsbvd, mhbrmnwrbk - fxnhekufhj)
-
29 Mar 2022
fwfuwuxrmn = xyxcrejlub wdertohxpn (byvnqdsbvd, jxzpncgydh - xpokqixpuc)
Phase 2
206
Placebo
(Placebo Q2W)
kobhmsjgxr(ksihuzhufu) = qgrmntifnv gmuurczgrs (wolfokzgjv, 31.86)
-
01 Nov 2021
(REGN3500 300 mg Q2W)
kobhmsjgxr(ksihuzhufu) = eafyfzdntv gmuurczgrs (wolfokzgjv, 22.46)
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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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