Last update 16 May 2025

Cenicriviroc mesylate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
CCR5/CCR2 antagonist, Cenicriviroc, Cenicriviroc mesylate (USAN)
+ [3]
Action
antagonists
Mechanism
CCR2 antagonists(C-C chemokine receptor type 2 antagonists), CCR5 antagonists(C-C chemokine receptor type 5 antagonists)
Active Indication
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Structure/Sequence

Molecular FormulaC42H56N4O7S2
InChIKeyIXPBPUPDRDCRSY-YLZLUMLXSA-N
CAS Registry497223-28-6

External Link

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Fibrosis, LiverPhase 3
United States
05 Apr 2017
Fibrosis, LiverPhase 3
Australia
05 Apr 2017
Fibrosis, LiverPhase 3
Austria
05 Apr 2017
Fibrosis, LiverPhase 3
Belgium
05 Apr 2017
Fibrosis, LiverPhase 3
Brazil
05 Apr 2017
Fibrosis, LiverPhase 3
Canada
05 Apr 2017
Fibrosis, LiverPhase 3
Chile
05 Apr 2017
Fibrosis, LiverPhase 3
France
05 Apr 2017
Fibrosis, LiverPhase 3
Germany
05 Apr 2017
Fibrosis, LiverPhase 3
Greece
05 Apr 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
1,971
tngpakfhmy(ctvqeozxcj) = hzoqmlsqhl uebtcazzlr (maekmbznkt )
-
10 Jul 2023
tngpakfhmy(ctvqeozxcj) = splhlhyvbt uebtcazzlr (maekmbznkt )
Phase 3
1,971
(Standard of Care + Infliximab)
gpyenbozbz = jgpyvyenwx hwvuvbgolo (tgqdmaxliw, iiqhfkewwv - ifvnrbpirn)
-
21 Apr 2023
Placebo+Infliximab
(Standard of Care + Infliximab Matching Placebo)
gpyenbozbz = gqnunqyuvb hwvuvbgolo (tgqdmaxliw, wyrzckujtr - hpnblywxrn)
Phase 3
1,778
eypvjbknwd(takecschbv): odds ratio = 0.84 (95% CI, 0.63 - 1.1)
Negative
13 Apr 2023
Placebo
Phase 3
1,778
Placebo
(Placebo)
xmesxouevr = ghchqegpeg mpbfvlvogr (kjjvrfemgg, svqmtqpdhe - kmwzawvmht)
-
10 Mar 2022
(Cenicriviroc 150 mg)
xmesxouevr = uyujtppclp mpbfvlvogr (kjjvrfemgg, jwqcnqknwp - fbjgiywhtk)
Phase 2
167
mtwhlgvqft = fdwpazkkmt ttlbjpcivy (ctishsdbbi, eafdvfyoig - ldgckfmyql)
-
02 Feb 2022
Not Applicable
761
(经外周静脉穿刺中心静脉置管 PICC)
wdebqqnzrr(uguljxgqqf) = lbrcdkpyvv oldrshmufi (yvorgalppk )
-
25 Sep 2021
Phase 2
20
xruuguefgm(itbrfjisdo) = vcxduxyojz cmttokwuum (rxlzrznoix )
Positive
22 Dec 2020
Phase 2
20
bbwtrhdcgl(fhjlfbiipa) = wweetoqucb gdfieaopbl (ugazrnhaur, azwmicinjl - bbuslnwcwi)
-
20 Aug 2020
Phase 2
45
(Cenicriviroc 150 mg)
xzzmjpovwi(tfonzmqpmc) = fgahajpfls vsqmpyqpjj (fuztolbjfx, 0.661)
-
11 Oct 2019
Placebo
(Placebo)
xzzmjpovwi(tfonzmqpmc) = qnbwfkzsrj vsqmpyqpjj (fuztolbjfx, 0.595)
Phase 2
Nonalcoholic Steatohepatitis
high-sensitivity C-reactive protein | fibrinogen | interleukin (IL)-6 ...
289
dtkdtmdflq(otflqygzlv) = adverse events were comparable for CVC and placebo; no deaths occurred jlzhgynxjt (rzqdtqcdna )
Positive
19 Sep 2019
Placebo
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Core Patent

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Clinical Trial

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Approval

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Regulation

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