Fosamprenavir calcium

Produced in the U.S., the generic anti-fungal drug is fully substitutable for Noxafil® LAKE ZURICH, Ill.--(BUSINESS WIRE)-- Fresenius Kabi announced today it has introduced Posaconazole Injection, a generic substitute for Noxafil®, for use in treating or preventing serious fungal infections in adults and children who have an increased chance of getting these infections due to a weakened immune system. Now available in the U.S., Posaconazole Injection is the newest addition to Fresenius Kabi’s portfolio of more than 30 anti-infective molecules. This press release features multimedia. View the full release here: Fresenius Kabi Posaconazole Injection, a generic substitute for Noxafil® (Photo: Business Wire) Available in a 300 mg per 16.7 mL vial, Posaconazole Injection is used to treat invasive aspergillosis, a serious fungal infection, in adults and teenagers 13 years of age and older. It is also used to prevent invasive aspergillus and candida infections in patients who are severely immunocompromised, including adults and pediatric patients age 2 or older. “The introduction of Posaconazole Injection reflects Fresenius Kabi’s ongoing commitment to expanding our portfolio of affordable generic options for the treatment and/or prevention of life-threatening infections,” said John Ducker, president and CEO of Fresenius Kabi USA. Posaconazole Injection is produced at the company’s pharmaceutical production site in Grand Island, New York. Fresenius Kabi has invested nearly $1 billion to expand and update its U.S. pharmaceutical production and distribution network. More than 70 percent of the product units shipped in the U.S. by Fresenius Kabi are drugs listed on the FDA’s Essential Medicines List. “We are doubling our U.S. manufacturing capacity to enhance the resilience of our supply chain, which helps assure fast, reliable service for our customers and the patients they serve,” said Lindsey Thomas, senior vice president of marketing of Fresenius Kabi USA. “Our investments will help patients gain access to the treatments they need – when and where they need them most.” Learn more about Fresenius Kabi’s commitment to strengthening its domestic supply chain at MoreInAmerica.com. About Fresenius Kabi Fresenius Kabi ( ) is a global health care company that specializes in injectable medicines, biosimilars, and technologies for infusion, transfusion, and clinical nutrition. The company’s products and services are used to help care for patients with critical and chronic conditions. The company’s U.S. headquarters is in Lake Zurich, Illinois. The company’s global headquarters is in Bad Homburg, Germany. To learn about U.S. career opportunities at Fresenius Kabi, visit us at and follow us on LinkedIn. References *Noxafil® is a registered trademark of Merck Sharp & Dohme LLC. About Posaconazole Injection Posaconazole is an azole antifungal indicated as follows: Posaconazole injection is indicated for the treatment of invasive aspergillosis in adults and pediatric patients 13 years of age and older. Posaconazole is indicated for the prophylaxis of invasive Aspergillus and Candida infections in patients who are at high risk of developing these infections due to being severely immunocompromised, such as hematopoietic stem cell transplant (HSCT) recipients with graft-versus-host disease (GVHD) or those with hematologic malignancies with prolonged neutropenia from chemotherapy as follows: Posaconazole injection: adults and pediatric patients 2 years of age and older. IMPORTANT SAFETY INFORMATION Posaconazole is contraindicated in persons with known hypersensitivity to posaconazole or other azole antifungal agents. Coadministration of Posaconazole with the following drugs is contraindicated; Posaconazole increases concentrations and toxicities of: Sirolimus CYP3A4 substrates (pimozide, quinidine): can result in QTc interval prolongation and cases of torsades de pointes (TdP) HMG-CoA Reductase Inhibitors Primarily Metabolized through CYP3A4 Ergot alkaloids Venetoclax: in patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) at initiation and during the ramp of phase Calcineurin-Inhibitor Toxicity: Posaconazole increases concentrations of cyclosporine or tacrolimus; reduce dose of cyclosporine and tacrolimus and monitor concentrations frequently. Arrhythmias and QTc Prolongation: Posaconazole has been shown to prolong the QTc interval and cause cases of TdP. Administer with caution to patients with potentially proarrhythmic conditions. Do not administer with drugs known to prolong QTc interval and metabolized through CYP3A4. Electrolyte Disturbances: Monitor and correct, especially those involving potassium (K+), magnesium (Mg++), and calcium (Ca++), before and during Posaconazole therapy. Hepatic Toxicity: Elevations in liver tests may occur. Discontinuation should be considered in patients who develop abnormal liver tests or monitor liver tests during treatment. Renal Impairment: Posaconazole injection should be avoided in patients with moderate or severe renal impairment (creatinine clearance <50 mL/min), unless an assessment of the benefit/risk to the patient justifies the use of Posaconazole injection. Concomitant Use with Midazolam: Posaconazole can prolong hypnotic/sedative effects. Monitor patients and benzodiazepine receptor antagonists should be available. Vincristine Toxicity: Concomitant administration of azole antifungals, including Posaconazole, with vincristine has been associated with neurotoxicity and other serious adverse reactions; reserve azole antifungals, including Posaconazole, for patients receiving a vinca alkaloid, including vincristine, who have no alternative antifungal treatment options. Venetoclax Toxicity: Concomitant administration of Posaconazole with venetoclax may increase venetoclax toxicities, including the risk of tumor lysis syndrome, neutropenia, and serious infections; monitor for toxicity and reduce venetoclax dose. Adult Patients: Common adverse reactions in studies with Posaconazole in adults are diarrhea, nausea, fever, vomiting, headache, coughing, and hypokalemia. Pediatric Patients: Common adverse reactions (incidence >20%) receiving 6 mg/kg Posaconazole injection in a study in pediatric patients are pyrexia, febrile neutropenia, vomiting, mucosal inflammation, pruritus, hypertension, hypokalemia, and stomatitis. To report SUSPECTED ADVERSE REACTIONS, contact Fresenius Kabi USA, LLC at 1-800-551-7176, option 5, or FDA at 1-800-FDA-1088 or . Drug Interactions: Interaction Drug Interaction Rifabutin, phenytoin, efavirenz Avoid coadministration unless the benefit outweighs the risks Other drugs metabolized by CYP3A4 Consider dosage adjustment and monitor for adverse effects and toxicity Digoxin Monitor digoxin plasma concentrations Fosamprenavir Monitor for breakthrough fungal infections Pregnancy: Based on animal data, may cause fetal harm. Pediatrics: Safety and effectiveness in patients younger than 2 years of age have not been established. Severe Renal Impairment: Monitor closely for breakthrough fungal infections. This Important Safety Information does not include all the information needed to use Posaconazole Injection safely and effectively. Please see the full prescribing information for Posaconazole Injection available at .

Proteases are enzymes that play a crucial role in the human body by breaking down proteins into smaller peptides or amino acids. These enzymes are involved in various physiological processes, including digestion, blood clotting, immune response, and cell signaling. Proteases help in the breakdown of dietary proteins into absorbable nutrients, aiding in digestion and nutrient absorption. They also regulate blood clotting by activating clotting factors. Additionally, proteases are involved in immune response by degrading foreign proteins and pathogens. Furthermore, these enzymes participate in cell signaling pathways, influencing various cellular processes such as growth, differentiation, and apoptosis. Overall, proteases are essential for maintaining proper protein homeostasis and ensuring the normal functioning of the human body. Viral proteases are a class of enzymes that hydrolyze the peptide chain structure of proteins and are essential enzymes for viral biosynthesis. Their function is to cleave and modify precursor proteins to obtain mature active proteins, thereby exerting normal physiological functions. Proteases play a crucial role in the life cycle of viruses, and proteases of different viruses have a certain degree of similarity. Therefore, viral proteases have become ideal targets in the development of broad-spectrum antiviral drugs. Most of the antiviral drugs approved by the Food and Drug Administration (FDA) are peptide analogs and macrocyclic compounds. They bind to the active site of the target protease, thereby exerting antiviral effects. Protease inhibitors against AIDS and Hepatitis C virus are the most innovative sources in the development of antiviral drugs, with at least half of antiviral drugs used to treat AIDS. FDA-approved protease inhibitors for AIDS include saquinavir, indinavir, ritonavir, nelfinavir, amprenavir, fosamprenavir, lopinavir, atazanavir, tipranavir, darunavir, and combination preparations. The analysis of the target Protease in the pharmaceutical industry reveals a competitive landscape with companies at different stages of development. Shanghai Pharmaceutical (Group) Co., Ltd. is leading with an approved drug, while other companies are in Phase 1 or Preclinical stages. The approved indications cover a wide range of medical conditions, indicating the potential therapeutic applications of drugs targeting Protease. The drug types progressing rapidly include Enzyme, Small molecule drug, and Chemical drugs, with biosimilars contributing to intense competition. China, the United States, and European countries are actively developing drugs targeting Protease. The future development of the target Protease will depend on the success of ongoing research and development efforts, as well as the ability of companies to bring innovative drugs to market. How do they work?Protease inhibitors are a class of drugs that inhibit the activity of proteases, which are enzymes responsible for breaking down proteins. Proteases play a crucial role in various biological processes, including digestion, blood clotting, and immune response. By inhibiting proteases, protease inhibitors can interfere with these processes and have therapeutic effects. From a biomedical perspective, protease inhibitors are commonly used in the treatment of viral infections such as HIV/AIDS. HIV protease inhibitors specifically target the protease enzyme of the human immunodeficiency virus (HIV), preventing it from cleaving viral polyproteins into functional proteins. This inhibition disrupts the viral replication cycle and helps control the progression of HIV infection. Protease inhibitors can also be used in the treatment of other medical conditions, including hepatitis C, cancer, and certain autoimmune disorders. In cancer therapy, protease inhibitors can help prevent the growth and spread of tumors by blocking proteases involved in tumor invasion and angiogenesis. It is important to note that protease inhibitors can have side effects and may interact with other medications. Therefore, their use should be carefully monitored and prescribed by healthcare professionals. List of Protease InhibitorsThe currently marketed Protease inhibitors include: Chymotrypsin(Shanghai Pharmaceuticals Holding Co., Ltd.)ANG-003Bismuthyl EcabetChymotrypsinogen/trypsinogenCGT-1507EP-007FLT3 TriTACIgA proteases(IGAN Biosciences)MRX-18Aprotinin(Bayer Ag)For more information, please click on the image below. What are Protease inhibitors used for?Protease inhibitors are commonly used in the treatment of viral infections such as HIV/AIDS.  For more information, please click on the image below to log in and search. How to obtain the latest development progress of Protease inhibitors?In the Synapse database, you can keep abreast of the latest research and development advances of Protease inhibitors anywhere and anytime, daily or weekly, through the "Set Alert" function. Click on the image below to embark on a brand new journey of drug discovery!