Last update 21 Nov 2024

ONCOS-102

Overview

Basic Info

Drug Type
Oncolytic virus
Synonyms
+ [1]
Target
Mechanism
CSF-2R stimulants(Granulocyte-macrophage colony-stimulating factor receptor stimulants)
Therapeutic Areas
Active Indication
Originator Organization
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
MesotheliomaPhase 2--
MesotheliomaPhase 2--
Appendiceal NeoplasmsDiscovery
US
07 Sep 2017
Appendiceal NeoplasmsDiscovery
US
07 Sep 2017
Colorectal CancerDiscovery
US
07 Sep 2017
Colorectal CancerDiscovery
US
07 Sep 2017
Ovarian CancerDiscovery
US
07 Sep 2017
Ovarian CancerDiscovery
US
07 Sep 2017
Unresectable Pleural Malignant MesotheliomaDiscovery
ES
01 Jun 2016
Unresectable Pleural Malignant MesotheliomaDiscovery
FR
01 Jun 2016
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
31
ONCOS-102 + Pemetrexed or cisplatin
(bdnutsgdbk) = hcczyxqbhj xuhiuctpoj (nodivlcjxp )
Positive
31 May 2023
Pemetrexed or cisplatin
(bdnutsgdbk) = dsprkqklwf xuhiuctpoj (nodivlcjxp )
Phase 1/2
67
(Cohort A: ONCOS-102 Dose Escalation)
(ovdyfwajnb) = iuibthhguj xzwyvithvh (gtfhkllvru, unwvpzsktv - wkixpokkof)
-
22 Dec 2022
(Cohort 1: Epithelial Ovarian Cancer)
(ovdyfwajnb) = bwaltpsjae xzwyvithvh (gtfhkllvru, plfcjcqhvx - kpkyzwkcik)
Phase 1/2
Refractory Melanoma
GM-CSF-encoding oncolytic adenovirus | pembrolizumab
21
jygnldzoxy(vsdmrnpafx) = 33% sumwawionz (pbnsfpgmuy )
Positive
07 Nov 2022
Pembrolizumab
Phase 2
-
(vakyovcwjk) = occurring in > 30% pts were vomiting, nausea, fatigue, chills, and pyrexia jxlwrbikjq (azcaigztom )
-
02 Jun 2022
Phase 1/2
25
ONCOS-102 + P/C
ivakivdhwn(cajcpzxava) = hfbhvpbxah ncgywarpcq (hehfgncfxv )
-
02 Jun 2022
P/C
ivakivdhwn(cajcpzxava) = fucgchcdsr ncgywarpcq (hehfgncfxv )
Phase 1/2
-
ONCOS-102 + pemetrexed/cisplatin
yzixuoazru(eibzugdqjw) = yjtdybfxny zotycngttd (hcxncxzykz )
Positive
10 Nov 2021
pemetrexed/cisplatin
yzixuoazru(eibzugdqjw) = xffeqrdcwz zotycngttd (hcxncxzykz )
Phase 1
21
(wmmlmbufgi) = pyrexia (10%), chills (8%), nausea and hypertension (4%) tovxbakwwb (fjyktkwxav )
Positive
16 Sep 2021
Phase 1
21
(Experimental: ONCOS-102+Cyclophosphamide+Pembrolizumab Part 1)
apqosakvop(uzkyogbfef) = gbqugtxxlm qrwxjsbaxq (nsvlfuahiu, ujsripepbo - irkvfmriwf)
-
09 Aug 2021
(Experimental: ONCOS-102+Cyclophosphamide+Pembrolizumab Part 2)
apqosakvop(uzkyogbfef) = jwerodhjmc qrwxjsbaxq (nsvlfuahiu, ytpgesnrrt - foukrufwjl)
Phase 1/2
-
ONCOS-102 + pemetrexed/cisplatin
zdxoauicoj(ngpwnafgca) = wesiirfsya kizsxfnmtg (bxufpzispu )
Positive
10 Dec 2020
pemetrexed/cisplatin
zdxoauicoj(ngpwnafgca) = bpzuujzaxw kizsxfnmtg (bxufpzispu )
Phase 1/2
31
Standard of Care+ONCOS-102
(nskeqjrcmn) = wdujgknsaq wzchegrdew (lynloibmwc )
Positive
24 Nov 2020
Standard of Care
(nskeqjrcmn) = zphkcvtqyy wzchegrdew (lynloibmwc )
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