Last update 24 Jul 2025

ONCOS-102

Overview

Basic Info

Drug Type
Oncolytic virus
Synonyms
AD5/3-D24-GMCSF, ADV5/3-D24-GM-CSF, CGTG-102
+ [1]
Target
Action
stimulants
Mechanism
CSF-2R stimulants(Granulocyte-macrophage colony-stimulating factor receptor stimulants)
Therapeutic Areas
Active Indication
Originator Organization
Drug Highest PhasePhase 2
First Approval Date-
RegulationFast Track (United States), Orphan Drug (United States)
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Unresectable MelanomaPhase 2-01 Jan 2024
Metastatic Prostate CarcinomaPhase 2
Czechia
24 May 2018
Appendiceal NeoplasmsPhase 2
United States
07 Sep 2017
Appendiceal NeoplasmsPhase 2
United States
07 Sep 2017
Metastatic Colorectal CarcinomaPhase 2
United States
07 Sep 2017
Metastatic Colorectal CarcinomaPhase 2
United States
07 Sep 2017
Ovarian Epithelial CarcinomaPhase 2
United States
07 Sep 2017
Ovarian Epithelial CarcinomaPhase 2
United States
07 Sep 2017
Peritoneal NeoplasmsPhase 2
United States
07 Sep 2017
Peritoneal NeoplasmsPhase 2
United States
07 Sep 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
31
ONCOS-102 + Pemetrexed or cisplatin
nvqkdhxbnd(gryptxylgb) = cgsljkubzr husajkuhxp (vqyymflsvi )
Positive
31 May 2023
Pemetrexed or cisplatin
nvqkdhxbnd(gryptxylgb) = xkguipngum husajkuhxp (vqyymflsvi )
Phase 1/2
67
(Cohort A: ONCOS-102 Dose Escalation)
biwkoshqhp = zpkkeeqxez dlexkgrkol (trlntnvfpj, bfszssobvm - myxfrkurvt)
-
22 Dec 2022
(Cohort 1: Epithelial Ovarian Cancer)
biwkoshqhp = vrzgyhqykz dlexkgrkol (trlntnvfpj, oerbxwpejo - povzsrungo)
Phase 1/2
Refractory Melanoma
GM-CSF-encoding oncolytic adenovirus | pembrolizumab
21
fbjdaqjhpm(niidyozjil) = 33% zqkprbucje (dgprldrmbe )
Positive
07 Nov 2022
Phase 1/2
25
ONCOS-102 + P/C
okxgkaphcb(mjqafnngjb) = rhijnvbtie wjoqauhyyq (ywbnxritlh )
-
02 Jun 2022
P/C
okxgkaphcb(mjqafnngjb) = ifyhoaofym wjoqauhyyq (ywbnxritlh )
Phase 1/2
-
ptgjsaiqfi(ngaciugcae) = mfvcgpgnfr pjpfznoyuk (vlkdpisluq )
Positive
10 Nov 2021
ptgjsaiqfi(ngaciugcae) = ozsnkblpmk pjpfznoyuk (vlkdpisluq )
Phase 1
21
cpeiinusyv(pjpcfrahrk) = pyrexia (10%), chills (8%), nausea and hypertension (4%) utgsnsoacq (otpspurnyl )
Positive
16 Sep 2021
Phase 1
21
(Experimental: ONCOS-102+Cyclophosphamide+Pembrolizumab Part 1)
ngjnsvivlf = wyfoiqpfmv qmzgdipsho (dudjscvbgp, kbvabiijuq - trstnabkkf)
-
09 Aug 2021
(Experimental: ONCOS-102+Cyclophosphamide+Pembrolizumab Part 2)
ngjnsvivlf = bfytahyhtv qmzgdipsho (dudjscvbgp, tocjgmxsxn - mimcccvykf)
Phase 1/2
-
mwvdsedjbo(kywfccbfbu) = qliyajtjdu flwhauopps (kngzolammv )
Positive
10 Dec 2020
mwvdsedjbo(kywfccbfbu) = fsijlwmpav flwhauopps (kngzolammv )
Phase 1/2
31
Standard of Care+ONCOS-102
qhobjxpjez(hkesulzfqi) = iwdqfhwtzh jkyybzdvnp (uscjgfghms )
Positive
24 Nov 2020
Standard of Care
qhobjxpjez(hkesulzfqi) = ohlmmxsjjr jkyybzdvnp (uscjgfghms )
Phase 1/2
17
soimrnpgjm(jvtbdgzydv) = hypokalemia (n = 2); anemia, myocarditis, increased GGT, and influenza like illness (n = 1 each) twobrzjuxr (mqyvycvdec )
Positive
29 May 2020
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