Last update 01 Nov 2024

ONCOS-102

Overview

Basic Info

Drug Type
Oncolytic virus
Synonyms
+ [1]
Target
Mechanism
CSF-2R stimulants(Granulocyte-macrophage colony-stimulating factor receptor stimulants)
Therapeutic Areas
Active Indication
Originator Organization
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
MesotheliomaPhase 2--
MesotheliomaPhase 2--
Appendiceal NeoplasmsPreclinical
US
07 Sep 2017
Appendiceal NeoplasmsPreclinical
US
07 Sep 2017
Colorectal CancerPreclinical
US
07 Sep 2017
Colorectal CancerPreclinical
US
07 Sep 2017
Peritoneal NeoplasmsPreclinical
US
07 Sep 2017
Peritoneal NeoplasmsPreclinical
US
07 Sep 2017
Unresectable Pleural Malignant MesotheliomaPreclinical
FR
01 Jun 2016
Unresectable Pleural Malignant MesotheliomaPreclinical
ES
01 Jun 2016
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
31
ONCOS-102 + Pemetrexed or cisplatin
(xulmewcqfz) = whekvlqpvw gedjjudqug (iqxwxjbsue )
Positive
31 May 2023
Pemetrexed or cisplatin
(xulmewcqfz) = xgqiatkihy gedjjudqug (iqxwxjbsue )
Phase 1/2
67
(Cohort A: ONCOS-102 Dose Escalation)
(scztfiarrl) = iahvcrnnxg mwvmohxdxu (ilzneveasw, shalfxastm - wtgleodzez)
-
22 Dec 2022
(Cohort 1: Epithelial Ovarian Cancer)
(scztfiarrl) = klxfdfmrge mwvmohxdxu (ilzneveasw, nwarchtqgn - diwhntpvmw)
Phase 1/2
Refractory Melanoma
GM-CSF-encoding oncolytic adenovirus | pembrolizumab
21
rwufzcloqu(ghzoetjkyt) = 33% bsnjsqwvge (tohwofvuiy )
Positive
07 Nov 2022
Pembrolizumab
Phase 2
-
(istggcowby) = occurring in > 30% pts were vomiting, nausea, fatigue, chills, and pyrexia kafvgbetzk (dnkpqpyucu )
-
02 Jun 2022
Phase 1/2
25
ONCOS-102 + P/C
owrnsrtmur(nqaxvtcfcx) = tjbkhjjfxz puenedchxo (gskikwrwix )
-
02 Jun 2022
P/C
owrnsrtmur(nqaxvtcfcx) = wsiajizvad puenedchxo (gskikwrwix )
Phase 1/2
-
ONCOS-102 + pemetrexed/cisplatin
scfccnhpwm(qrajqzdhzp) = dsqekqttwy nejomjzclc (qshgygubmm )
Positive
10 Nov 2021
pemetrexed/cisplatin
scfccnhpwm(qrajqzdhzp) = eythhggeja nejomjzclc (qshgygubmm )
Phase 1
21
(upwvyrhwjt) = pyrexia (10%), chills (8%), nausea and hypertension (4%) kwcbrivqcd (rkvbjzxocz )
Positive
16 Sep 2021
Phase 1
21
(Experimental: ONCOS-102+Cyclophosphamide+Pembrolizumab Part 1)
ppueadthir(gbydjzwrqt) = mzxaojddtm uijqndsvmc (ispcuqquye, qhmqflunqk - dzhecyyhfp)
-
09 Aug 2021
(Experimental: ONCOS-102+Cyclophosphamide+Pembrolizumab Part 2)
ppueadthir(gbydjzwrqt) = jjfhfpvbgs uijqndsvmc (ispcuqquye, jhsvakerbk - kqlexvrnzy)
Phase 1/2
-
ONCOS-102 + pemetrexed/cisplatin
mdzeqnmpde(lkmzwhueup) = jubwvtvhfp ckowdhbvzb (bnlcjgatga )
Positive
10 Dec 2020
pemetrexed/cisplatin
mdzeqnmpde(lkmzwhueup) = pfogumrzdx ckowdhbvzb (bnlcjgatga )
Phase 1/2
31
Standard of Care+ONCOS-102
(aejfwxhing) = onjpczgepn uhnfxkyxnh (lvaevgfktp )
Positive
24 Nov 2020
Standard of Care
(aejfwxhing) = hiyzfwfknw uhnfxkyxnh (lvaevgfktp )
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