Sponge-Like Dressings Based on the Association of Chitosan and Sericin for the Treatment of Chronic Skin Ulcers. II. Loading of the Hemoderivative Platelet Lysate

Q3 · MEDICINE

Article

Author: Tenci, Marika ; Riva, Federica ; Rossi, Silvia ; Del Fante, Claudia ; Sandri, Giuseppina ; Caramella, Carla ; Ferrari, Franca ; Bonferoni, Maria C ; Nicoletti, Giovanni ; Mori, Michela

Platelet lysate (PL) was loaded into dressings based on chitosan glutamate (CSG) low and high molecular weight, sericin (Ser), and glycine (Gly). A synergic effect of Ser and PL on fibroblast proliferation was proved in vitro. Two different PL loading approaches were considered: the first provided to prepare dressings by freeze-drying a mixture of PL and CSG/Gly/Ser solution, the second approach consisted in the extemporarily loading of PL in the CSG/Gly/Ser freeze-dried dressings. As for the first approach, PL loading did not produce any variation in dressing mechanical properties. Such dressings absorbed a high amount (about 8-fold of dry weight) of phosphate-buffered saline (fluid mimicking wound exudate), forming a gel with pseudoplastic and elastic properties. Platelet-derived growth factor AB assay indicated that neither freeze-drying nor the excipients alter PL growth factor content. As for the second approach, mechanical and rheological properties of the gel formed upon PL absorption enabled to choose a PL loading of about 90 μL/cm(2). Upon contact with fibroblasts, all PL loaded formulations increased the number not only of viable cells but also of those in the proliferative phase. Histological studies effected on human skin strips pointed out the positive effect of PL loaded dressings on dermal matrix reconstruction.

01 Aug 2009·Cadernos de Saúde PúblicaQ4 · MEDICINE

Revisão sistemática da eficácia do interferon alfa (convencional, peguilado) e lamivudina para o tratamento da hepatite crônica B

Q4 · MEDICINE

ReviewOA

Author: Acurcio, Francisco de Assis ; Silva, Grazielle Dias ; Almeida, Alessandra Maciel ; Silva, Dirce Inês da ; Guerra Jr, Augusto Afonso

01 Dec 1987·Plant Cell ReportsQ2 · BIOLOGY

Regeneration of plants from mesophyll protoplasts of the wild crucifer Eruca sativa Lam.

Q2 · BIOLOGY

Article

Author: Gouri Chatterjee ; S. K. Sen ; Samir R. Sikdar ; Srabani Das

Protoplasts isolated from mesophyll cells of Eruca sativa Lam., cultured on suitable medium, underwent sustained cell divisions to form calli. The plating efficiency was found to be 0.4%. The protoplast-derived calli subsequently produced plantlets through organogenesis (15.71%) and somatic embryogenesis (11.25%). Regenerated plants exhibited normal appearance. These results indicate potential to introgress desirable traits from this wild crucifer into important oilseed and cole Brassicas by protoplast fusion and hybrid recovery.

100 Deals associated with Lamotrigine/Sertraline Hydrochloride

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Indication	Highest Phase	Country/Location	Organization	Date
Back Pain	Phase 2	RO	Meditop Pharmaceutical Ltd.	07 Jun 2014

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


IAS2007	Not Applicable	Hepatitis B \| HIV Infections	-	LAM/AZT/EFV Gp1LAM/AZT/EFV Gp1LAM/AZT/EFV Gp1	pbgsbrqubo(gxxjmrfeik) = dvxbcljpoz vcjkgignjw (fjlecuxoiz ) View more	-	01 Jan 2007
				TDF/AZT/EFV Gp2TDF/AZT/EFV Gp2TDF/AZT/EFV Gp2	pbgsbrqubo(gxxjmrfeik) = cqedbouvsz vcjkgignjw (fjlecuxoiz ) View more
IAS2002	Not Applicable	HIV Infections	-	ADV 10mg	(ijrehikbni) = ykhbddeqqe iqzkwygzed (ztqehthifo ) View more	-	01 Jan 2002
				LAM	(ijrehikbni) = lkzbynddlu iqzkwygzed (ztqehthifo ) View more

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