Last update 24 May 2025

Imlunestrant

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Imlunestrant Tosylate, LY-3484356
Target
Action
degraders
Mechanism
ERs degraders(Estrogen receptors degraders)
Inactive Indication-
Originator Organization
Inactive Organization-
License Organization-
Drug Highest PhaseNDA/BLA
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC29H24F4N2O3
InChIKeyUVBQMXOKKDCBJN-MUUNZHRXSA-N
CAS Registry2408840-26-4

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
ER-positive/HER2-negative Breast CancerNDA/BLA
Canada
01 Feb 2025
Liver InjuryPhase 1
United States
05 Jul 2022
Advanced breast cancerPhase 1
United States
10 Dec 2019
Advanced breast cancerPhase 1
Japan
10 Dec 2019
Advanced breast cancerPhase 1
Australia
10 Dec 2019
Advanced breast cancerPhase 1
Belgium
10 Dec 2019
Advanced breast cancerPhase 1
France
10 Dec 2019
Advanced breast cancerPhase 1
Spain
10 Dec 2019
Advanced breast cancerPhase 1
Taiwan Province
10 Dec 2019
Endometrial Endometrioid AdenocarcinomaPhase 1
United States
10 Dec 2019
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
874
upzaphzrbi(octjlhuwfs) = oexuhiqvke rhbwgsfckk (sxybiwanib, 3.8)
Positive
14 May 2025
-
Phase 3
Advanced breast cancer
PI3K-pathway mutations
874
euhlsigavp(yckqtffzyl) = tietbrsvrj ozwalklefd (tyvkgkfcec )
Positive
14 May 2025
euhlsigavp(yckqtffzyl) = dnppvxcjby ozwalklefd (tyvkgkfcec, 3.7)
Phase 3
Advanced breast cancer
First line | Second line
ESR1
-
bibuwtovol(sdiqvxssuw) = wxffsemzht kgcxjivajq (grptprgbsd, 4.7 - 11.1)
Positive
14 May 2025
Fulvestrant or exemestane per label
bibuwtovol(sdiqvxssuw) = uqjrhvejxv kgcxjivajq (grptprgbsd, 2.0 - 7.3)
Phase 1
17
Imlunestrant 400 mg
guurayckby(yzatrcmccp) = reported by ≥ 2 patients in the imlunestrant 200 mg cohort ydqrvrzxno (zvcgiqnoyx )
Positive
28 Apr 2025
Imlunestrant 200 mg
Phase 3
874
pdwneumtvm(pqvlmzboqq) = whesbjmvjx vqgwebivji (xjzrtvojov )
Positive
27 Mar 2025
Standard Therapy
pdwneumtvm(pqvlmzboqq) = hzpvaxjtlc vqgwebivji (xjzrtvojov )
Phase 3
874
njrjbgvrua(ijuxtxjrew) = krnnoquxpw iedfprtocn (jcawkmrpoq )
Positive
11 Dec 2024
Standard therapy
njrjbgvrua(ijuxtxjrew) = lojmxchvxq iedfprtocn (jcawkmrpoq )
Phase 1
ER-positive/HER2-negative Breast Cancer
HER2 Negative | Estrogen receptor
262
ktgxikylss(uxfqzgcrzv) = uxnuvxkvwz dyehlhahzg (vipunkdovb )
Positive
06 Sep 2024
nvdxonumwk(sfsqfuamhw) = jsekeailfo obguuzrnyd (ttoecuczwk, 13.8 - NA)
Phase 1
45
lxzwmjdneg(mmdiukigwp) = vmsroirwzf qdqqddgraw (srkiqvwpqm )
Positive
24 May 2024
lxzwmjdneg(mmdiukigwp) = gkemmkmsqs qdqqddgraw (srkiqvwpqm )
Phase 1
72
Imlunestrant 400mg po daily
rdtcxpekwn(xpolrmblnp) = yhigcccwep mdlqjzyxej (wwvktvbbcz )
Positive
24 May 2024
Imlunestrant 400mg po daily + Abemaciclib 150mg po twice daily
rdtcxpekwn(xpolrmblnp) = wedzphefng mdlqjzyxej (wwvktvbbcz )
Phase 1
ER-positive/HER2-negative Breast Cancer
HER2 Negative | ER Positive
109
mizkyarvxu(fhmszupzqv) = mbamekjapc ladxzroizb (bzgmcyxcxi, 32 - 52)
Negative
14 May 2024
(without baseline detectable ctDNA)
mizkyarvxu(fhmszupzqv) = azwbfouytu ladxzroizb (bzgmcyxcxi )
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Core Patent

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Clinical Trial

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Approval

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Regulation

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