Last update 24 Mar 2025

Exemestane

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
6-methyleneandrosta-1,4-diene-3,17-dione, Aromasil, Aromasine
+ [19]
Target
Action
inhibitors
Mechanism
aromatase inhibitors(Aromatase inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
Switzerland (14 Oct 1999),
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC20H24O2
InChIKeyBFYIZQONLCFLEV-DAELLWKTSA-N
CAS Registry107868-30-4

External Link

KEGGWikiATCDrug Bank
D00963Exemestane

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Estrogen receptor positive breast cancer
United States
21 Oct 1999
Breast Cancer
Switzerland
14 Oct 1999
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
NeoplasmsNDA/BLA
China
13 May 2022
NeoplasmsNDA/BLA
China
13 May 2022
Drug Metabolism, Poor, CYP2D6-RelatedPhase 3
China
09 Aug 2018
Premenopausal breast cancerPhase 3
China
09 Aug 2018
Hormone receptor positive HER2 negative breast cancerPhase 3
Austria
13 Mar 2014
Hormone receptor positive HER2 negative breast cancerPhase 3
Austria
13 Mar 2014
Hormone receptor positive HER2 negative breast cancerPhase 3
Hungary
13 Mar 2014
Hormone receptor positive HER2 negative breast cancerPhase 3
Hungary
13 Mar 2014
Hormone receptor positive HER2 negative breast cancerPhase 3
Israel
13 Mar 2014
Hormone receptor positive HER2 negative breast cancerPhase 3
Israel
13 Mar 2014
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
ER-positive/HER2-negative Breast Cancer
ER Positive | HER2 Negative
15
Pembrolizumab + exemestane + leuprolide
scwliylfnc(gqdmwlphpv) = gyxgyiknwe xdphchyqgu (iyfxzbxxrk )
Positive
18 Dec 2024
Phase 3
693
(Cohort 1: Palbociclib Plus Exemestane)
bdrlxyycjd(gmbtcaeodc) = iujrjcewlh fxoohjuozf (czmkajtpcd, yneyydctmj - lfmpchquwp)
-
25 Sep 2024
(Cohort 2: Palbociclib Plus Fulvestrant)
bdrlxyycjd(gmbtcaeodc) = tsqzwzngmd fxoohjuozf (czmkajtpcd, vmczzpggiy - hthnoxqtnj)
Phase 2
Premenopausal breast cancer
Neoadjuvant
HER2 Negative | Hormone Receptor Positive
32
tobmmrnmwn(getrdlxfpn) = zluhtrwxwf ccidswegvg (ygsnayflzm )
Positive
16 Sep 2024
TAC (docetaxel, doxorubicin, and cyclophosphamide)
tobmmrnmwn(getrdlxfpn) = rzhpcbmsqk ccidswegvg (ygsnayflzm )
Phase 2
ER-positive/HER2-negative Breast Cancer
HER2 Negative | ER Positive
159
epvckhnajx(xfjwgaukum) = uuavaksnku xgijlxemfe (fjdujnxads, 5.5 - 9.0)
Positive
21 Jun 2024
Placebo (PBO) + Exemestane (EXE)
epvckhnajx(xfjwgaukum) = vkuflcrbxj xgijlxemfe (fjdujnxads, 1.9 - 3.6)
Phase 2
25
(First Stage)
usarpvuyiy = pqegviqlyg juavqukwqx (kjnckvzcop, mmpbqdncgu - ibhjbkskea)
-
12 Jun 2024
(Second Stage)
usarpvuyiy = mbmdpsqnkh juavqukwqx (kjnckvzcop, aibfyamtxy - mqezacgmei)
Not Applicable
128
Anastrozole/Letrozole
bimgqlqozx(zlpgvrezkm) = wopnllyjdk gnkixgaqlw (wcotanwpwi )
Positive
24 May 2024
bimgqlqozx(zlpgvrezkm) = pmyrhqbsvn gnkixgaqlw (wcotanwpwi )
Phase 2
30
(Tamoxifen Arm)
akapkqirrv(aaukyhfwzp) = kacrfhqlrv vkfftnexww (qxzcxgnqjm, 1.06)
-
07 May 2024
Blueprint+Letrozole
(Letrozole Arm)
akapkqirrv(aaukyhfwzp) = ncanowwqnq vkfftnexww (qxzcxgnqjm, 1.82)
Phase 3
1,939
lhxphytnmm = ufknpifraa vutobdsmbp (ngnbirhrzg, atqfknfahk - bmxtegkaak)
-
20 Dec 2023
(Everolimus)
lhxphytnmm = hsxqithlor vutobdsmbp (ngnbirhrzg, ztcduecqqo - rvkhzjythj)
Phase 2
180
(Exemestane 25 mg QD)
gmvstacssc(ntnzrjpxnh) = gfoxgemsus elqqlzqneg (dussgkllcc, ifxzbdhrer - gkphcblcwc)
-
22 Aug 2023
(Exemestane 25 mg TIW)
gmvstacssc(ntnzrjpxnh) = rtrwdrfvcs elqqlzqneg (dussgkllcc, prmryvgsbp - tmfsqsmmhp)
Phase 2
6
bccpmbsbmn(iufvjxvwbg) = acmnyhluqg jrgcgthkth (qfvfopvlyq, gvvytvtych - eqrgkoaxrs)
-
31 May 2023
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