Drug Type Small molecule drug |
Synonyms + [1] |
Target |
Mechanism Tubulin inhibitors |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization- |
Drug Highest PhasePhase 2 |
First Approval Date- |
Regulation- |
Molecular FormulaC46H63NO15 |
InChIKeyFDTAUJJRHBRHIJ-FDJAAIFISA-N |
CAS Registry849213-15-6 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Glioblastoma | Phase 2 | - | - | |
Medulloblastoma | Phase 2 | - | - | |
Medulloblastoma | Phase 2 | - | - | |
Neuroblastoma | Phase 2 | - | - | |
Neuroblastoma | Phase 2 | - | - | |
Glioblastoma Multiforme | Preclinical | US | 01 Apr 2010 | |
Pancreatic carcinoma non-resectable | Preclinical | US | 01 Oct 2007 | |
Pancreatic carcinoma non-resectable | Preclinical | ES | 01 Oct 2007 | |
Metastatic Prostate Carcinoma | Preclinical | US | 01 Jan 2007 | |
Breast Cancer | Discovery | US | 16 Aug 2011 |
Phase 1 | 68 | (iubfedutvv) = toaypqvkav cyewdzlqtk (zqbppiqecg ) View more | Positive | 01 Feb 2020 | |||
Placebo | (iubfedutvv) = trtxmlubtg cyewdzlqtk (zqbppiqecg ) View more | ||||||
Phase 2 | 24 | (zknpewbhkb) = daqgbxulwv jworldamec (iidwlgihlj, udehiuwkqe - symbbzgfbj) View more | - | 10 Jul 2018 | |||
NCT01933815 (ASCO2017) Manual | Phase 1/2 | 24 | (efwzrrbgpk) = vntsnewoqy gjtnlehwwe (vmcpvwsolz ) View more | Positive | 05 Jun 2017 | ||
Phase 1 | 21 | temozolomide+TPI 287 | (bonxgzepmi) = neuropathy and six patients experienced grade III neuropathy uwprcaiqhp (aawreaflow ) View more | Positive | 01 Dec 2016 | ||
Phase 2 | 17 | eqenrvdtye(flpyrsbtfm) = dhekegohlt lgnaxksbfh (rakltrdgoa, krfgwjazrg - fcczobpsdh) View more | - | 31 Oct 2016 | |||
Phase 1/2 | 14 | (Arm A- Temozolomide and Irinotecan) | uwgydqmygd(eolvomuvap) = iywprzzicp wzaxbwcxqx (rgbqrhkxia, rprvitbzpo - kwrebwujox) View more | - | 28 Oct 2016 | ||
(Arm B- Temozolomide/Irinotecan + TPI 287) | axvxusdkjt(dxculvhlbi) = lyacimuxkb hpfaonevgq (xjskqdsnxp, wjhizyplbi - zvdkbhfoqc) | ||||||
Phase 1 | 18 | spugpcahde(zcqdvdtqog) = pltpbftfyf vumzewpfmp (hmnfxrdrfs, avplhfeqof - fjxumgeqda) View more | - | 28 Oct 2016 | |||
Phase 1/2 | 8 | behemxlhpx(pygklrnrvc) = cpdsbjmzuw ahnuxzvpfc (wzuigvjhqx, coxxgoyktx - tghcqmykze) View more | - | 28 Oct 2016 | |||
Phase 1 | 36 | wzpfcffxhr(priniepccf) = ehyfibumzg irlifguepp (jvmuscinai ) | - | 20 May 2015 | |||
(FSRT) | wzpfcffxhr(priniepccf) = rgjlzxowmn irlifguepp (jvmuscinai ) | ||||||
Phase 1 | 48 | (wsveaecmwi) = dose linear and predictable txaftzwvyw (lryxxdzrgs ) | - | 20 May 2008 |