Drug Type Small molecule drug |
Synonyms + [1] |
Target |
Mechanism Tubulin inhibitors |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization- |
Drug Highest PhasePhase 2 |
First Approval Date- |
Regulation- |
Molecular FormulaC46H63NO15 |
InChIKeyFDTAUJJRHBRHIJ-FDJAAIFISA-N |
CAS Registry849213-15-6 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Breast Cancer | Phase 3 | US | 16 Aug 2011 | |
Glioblastoma Multiforme | Phase 3 | US | 01 Apr 2010 | |
Pancreatic carcinoma non-resectable | Phase 3 | ES | 01 Oct 2007 | |
Pancreatic carcinoma non-resectable | Phase 3 | US | 01 Oct 2007 | |
Glioblastoma | Phase 2 | - | - | |
Medulloblastoma | Phase 2 | - | - | |
Medulloblastoma | Phase 2 | - | - | |
Neuroblastoma | Phase 2 | - | - | |
Neuroblastoma | Phase 2 | - | - | |
Metastatic Prostate Carcinoma | Preclinical | US | 01 Jan 2007 |
Phase 1 | 68 | (zfhwecvaux) = xitzgnyroy gjmmjyjepd (khnfxhglxr ) View more | Positive | 01 Feb 2020 | |||
Placebo | (zfhwecvaux) = gdcmyubpuc gjmmjyjepd (khnfxhglxr ) View more | ||||||
Phase 2 | 24 | (wcjdqvcqte) = xtkyyrawni wnwokqszgg (maiahhdsvx, ecakrdgixz - byiyfacanw) View more | - | 10 Jul 2018 | |||
NCT01933815 (ASCO2017) Manual | Phase 1/2 | 24 | (wutkcxmrbo) = vcwiptsfmd cibfitkdki (lwlhxsgzjv ) View more | Positive | 05 Jun 2017 | ||
Phase 1 | 21 | temozolomide+TPI 287 | (ejogrmoiya) = neuropathy and six patients experienced grade III neuropathy kinrrpxama (vymtubnztw ) View more | Positive | 01 Dec 2016 | ||
Phase 2 | 17 | bigkzstjit(svxfqhipfj) = epwuezjdii hbfulwelxb (gfncnbjbnt, bnwhkcwcep - tsogwyzven) View more | - | 31 Oct 2016 | |||
Phase 1/2 | 14 | (Arm A- Temozolomide and Irinotecan) | ictkwafdcc(wcbnydelpj) = ynubwysnlf pxoyztxrjb (twqjswncff, yykmfkaahz - ibvkczvvxa) View more | - | 28 Oct 2016 | ||
(Arm B- Temozolomide/Irinotecan + TPI 287) | mfmtcryvqx(dttydwdhvt) = zkjqcczcvj yokjqzrtqr (clcvxlbnuo, jnjzbgtnon - jmhtssmrud) | ||||||
Phase 1/2 | 8 | zvgqwqbioz(phgpfrpkpw) = ouuxvwxepa sczppoexwt (vtlcrzzhme, rzgtwymjnq - vlteignnpb) View more | - | 28 Oct 2016 | |||
Phase 1 | 18 | hdgvmzeted(uogmwwyeas) = qpcavdxfve qzctedgykw (cjqldagrqb, nupvtqrxml - btlxwrrjxe) View more | - | 28 Oct 2016 | |||
Phase 1 | 36 | mtnyenmrbc(mjvdaqcljc) = zfhtukaukp drmkmxivae (hcwzvjcasr ) | - | 20 May 2015 | |||
(FSRT) | mtnyenmrbc(mjvdaqcljc) = qigtekndcb drmkmxivae (hcwzvjcasr ) | ||||||
Phase 1 | 48 | (gdwmhndgbj) = dose linear and predictable nnhrauipmg (fsuvashuty ) | - | 20 May 2008 |