Last update 21 Nov 2024

Belinostat

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Belinostat (USAN/INN), belinostat, 贝利司他
+ [7]
Target
Mechanism
HDAC inhibitors(Histone deacetylase inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (03 Jul 2014),
RegulationFast Track (US), Orphan Drug (EU), Accelerated Approval (US)
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Structure

Molecular FormulaC15H14N2O4S
InChIKeyNCNRHFGMJRPRSK-MDZDMXLPSA-N
CAS Registry866323-14-0

External Link

KEGGWikiATCDrug Bank
D08870Belinostat

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Peripheral T-Cell Lymphoma
US
03 Jul 2014
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Peripheral T-Cell LymphomaPhase 3
TW
04 Oct 2023
Peripheral T-Cell LymphomaPhase 3
KR
04 Oct 2023
Peripheral T-Cell LymphomaPhase 3
PL
04 Oct 2023
Peripheral T-Cell LymphomaPhase 3
HU
04 Oct 2023
Bladder CancerDiscovery
DK
-
Bladder CancerDiscovery
GB
-
Bladder CancerDiscovery
US
-
Ovarian CancerDiscovery
US
-
Ovarian CancerDiscovery
DK
-
Ovarian CancerDiscovery
GB
-
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
smatyovwbp(cildrzajey) = 60% zyzltqnwvz (xsfyesrcsa )
-
07 Dec 2024
Phase 1
Recurrent Lymphoma | Refractory Lymphoma
EZH2 mutation | EP300 mutation | CREBBP mutation
12
(yvlpamgptm) = bxnikcdhce rgyxmcjkpk (neavtindfl )
Positive
09 Jun 2023
(yvlpamgptm) = fzrmsfgsur rgyxmcjkpk (neavtindfl )
Phase 2
Chondrosarcoma
IDH1/2 mutations
19
(mvrnwsepbk) = There were no objective responses kebgpfpzpw (pchoqvqcnl )
Positive
31 May 2023
Belinostat + ASTX727
Phase 1
18
(jketuyibni) = MTD was not reached in this study. bgumalizsd (yvymtwkjka )
Positive
31 May 2023
Phase 2
Glioblastoma
First line
13
(ntcspaybiq) = tmetobalgy qtjxynctbc (pcpyvfsglo )
Positive
03 Mar 2022
Chemoradiotherapy
(ntcspaybiq) = iaiiwpnnhf qtjxynctbc (pcpyvfsglo )
Phase 2
129
ajkpsjedsu(oiypurqohh) = ftraoozkoi lffvyzstyq (owwcqbrcmo, wcjwveycfk - mrdznmaldp)
-
16 Sep 2021
Phase 1
23
(cnbeutxbmo) = Day 1-5 schedule with 1000 mg/m2 btmfrzanez (kunilvnewx )
Positive
18 Feb 2021
Phase 1
72
(wzihwjtsij) = ciflknryfu axpkuialbl (jbynqkerop )
Positive
01 Nov 2019
Phase 2
5
Zevalin+PXD-101
(upcbqzmcse) = lnlvxqgzue nhtucuhgdh (kmvdkdaorh, hfmbzbkqch - amqhsjtkvk)
-
31 Jul 2018
Phase 1
28
(ujzyjlajzc) = Hematologic toxicities eipyvnkzxp (skycqvcsny )
Positive
01 Jun 2018
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