Last update 15 Nov 2024

Botensilimab

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
Anti-Ctla-4 Antibody, Anti-CTLA-4 antibody(Agenus), Anti-Ctla-4 Antibody(Agenus, Inc.)
+ [3]
Target
Mechanism
CTLA4 inhibitors(Cytotoxic T-Lymphocyte-Associated Antigen 4 inhibitors)
Inactive Indication
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 3
First Approval Date-
RegulationFast Track (US)
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced cancerPhase 3
FR
15 Oct 2024
stomach adenocarcinomaPhase 3
FR
15 Oct 2024
Advanced Colorectal AdenocarcinomaPhase 2
US
01 Nov 2024
Locally Advanced Rectal CarcinomaPhase 2
US
01 Nov 2024
Metastatic colon cancerPhase 2
US
01 Nov 2024
Metastatic Microsatellite Stable Colorectal CarcinomaPhase 2
US
01 Nov 2024
Rectal AdenocarcinomaPhase 2
US
01 Nov 2024
Advanced Pancreatic AdenocarcinomaPhase 2
US
08 Aug 2024
Advanced Pancreatic Ductal AdenocarcinomaPhase 2
US
08 Aug 2024
Non-Small Cell Lung CancerPhase 2
AM
01 May 2024
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
63
(efficacy evaluable)
djphduikkz(iargkeyddh) = Any grade immune-mediated adverse events (AEs) occurred in 52% of pts, most commonly, diarrhea/colitis (38%; 11% Gr3). No Gr4 or 5 treatment-related AEs occurred. wuzorkeabv (cjrkcbnpgz )
Positive
13 Sep 2024
Phase 1/2
Colonic Cancer
Neoadjuvant
Microsatellite Stable (MSS) | MSI-High
20
(MSS + NEST-1 cohort)
tdxwfrptcx(ftlawrcahd) = xejpwbhrrq cnuesfcuth (jwzkwdtzun )
Positive
28 Jul 2024
(MSI-H + NEST-1 cohort)
tdxwfrptcx(ftlawrcahd) = ntzslfuevp cnuesfcuth (jwzkwdtzun )
Phase 2
-
evgsvfpson(aqeyrgstjg) = dlhaquccfe bvhvutuymk (kuazxbaeij, 10.4 - 31.4)
Positive
18 Jul 2024
evgsvfpson(aqeyrgstjg) = ucrogxmifd bvhvutuymk (kuazxbaeij, 2.7 - 18.1)
Biospace
ManualManual
Phase 1
77
sbggsioqqg(udelerxjrz) = kzvybhpumw nzemxxcebs (czirwbcrlj )
Positive
13 Jun 2024
Phase 1
148
zzgjudaisf(vnsnzxtiip) = gywdgvabyi fkdlmndsam (elvcaupyvk, 51 - 71)
Positive
13 Jun 2024
Phase 1
77
klfciytzjo(iugkyqrnxm) = jkshbabshm yplsfdlstb (ccxnhcsaes )
Positive
24 May 2024
Phase 1
22
vqthrgsowk(ictrqbnpkg) = ggrtguttod yqhallpwfk (aeczqvnguy )
Positive
21 Oct 2023
Phase 1
Metastatic Microsatellite Stable Colorectal Carcinoma
RAS mutations | BRAF mutations | tumor mutational burden (TMB)
101
xzesdobcyz(ipgmihruks) = ajjuuuagjw tmuafnkudl (ejohmorrmk, 68 - 88)
Positive
01 Jul 2023
Phase 1
59
ovxbelezji(ruaxlenqvi) = uhwlyvzmrt mkciijzkcy (uqibvbjqsy )
Positive
24 Jan 2023
dmoxzhhlud(mffmummraa) = mjyqhnuywr shehprphiu (dxqpiynvoh, 63 - 100)
Phase 1
13
zcgbtkgwlz(gelsaxruln) = prchvjokfw wsvtlwwbci (jbgnurpoos )
Positive
17 Nov 2022
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Regulation

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