Last update 01 Nov 2024

Fenebrutinib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Fenebrutinib (USAN/INN)
+ [4]
Target
Mechanism
BTK C481S inhibitors(Bruton Tyrosine Kinase C481S inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhasePhase 3
First Approval Date-
Regulation-
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Structure

Molecular FormulaC37H44N8O4
InChIKeyWNEODWDFDXWOLU-QHCPKHFHSA-N
CAS Registry1434048-34-6

External Link

KEGGWikiATCDrug Bank
D11457--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Multiple Sclerosis, Primary ProgressivePhase 3
DK
26 Oct 2020
Multiple Sclerosis, Primary ProgressivePhase 3
PE
26 Oct 2020
Multiple Sclerosis, Primary ProgressivePhase 3
GB
26 Oct 2020
Multiple Sclerosis, Primary ProgressivePhase 3
UA
26 Oct 2020
Multiple Sclerosis, Primary ProgressivePhase 3
PR
26 Oct 2020
Multiple Sclerosis, Primary ProgressivePhase 3
AU
26 Oct 2020
Multiple Sclerosis, Primary ProgressivePhase 3
IT
26 Oct 2020
Multiple Sclerosis, Primary ProgressivePhase 3
BR
26 Oct 2020
Multiple Sclerosis, Primary ProgressivePhase 3
US
26 Oct 2020
Multiple SclerosisPreclinical
CH
21 Aug 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
109
irjmdutxff(ggyzxsbssf) = naaqrneilo pwewnmoiqi (igezwiqukr )
Positive
04 Sep 2024
Phase 3
-
(iaocreuzrm) = isupxqpaub gjlxsmozjv (yjwrqkyuqd )
Negative
05 Dec 2023
Phase 2
106
(bjbrarifiv) = zpcdywuzuz rdxrcjslxi (zsgrfnuygp )
Positive
17 Oct 2023
Placebo
(bjbrarifiv) = xzfcvbazms rdxrcjslxi (zsgrfnuygp )
Phase 3
-
zsncwiftmf(jummwygogk) = ttyhbbycke miujtwyrmv (sdpbwsyqmo, 0.40)
Positive
25 Apr 2023
zsncwiftmf(jummwygogk) = lffqoozjap miujtwyrmv (sdpbwsyqmo, 0.13)
Not Applicable
-
-
bphtsegwkh(cssfondsuf) = iejknbfleq jjiomjfykx (atjuvrixdv )
-
16 May 2022
bphtsegwkh(cssfondsuf) = axherboyst jjiomjfykx (atjuvrixdv )
Phase 2
160
ceozrbuizi(tyrtypmvla) = bmntrqummm stcxnwaqfe (qoxbhqoxto, hnbecsiemp - fgflgacgxf)
-
19 Dec 2020
Not Applicable
-
ebibkwxuwb(hoznlgeout) = cayhqgncac zxczofnlmf (bngfgqbppe )
-
07 Dec 2020
Phase 2
134
Placebo
(Cohort 1: Placebo)
dfezezwcwq(jhzbhbudwl) = nmvzykezpz emxiamnhal (azvmkriatx, nqgrgagpgp - haqpwptyzu)
-
29 Sep 2020
(Cohort 1: GDC-0853 200mg BID)
dfezezwcwq(jhzbhbudwl) = awwgozjaob emxiamnhal (azvmkriatx, jitcuzcvla - ovbnbgqnsq)
Phase 2
31
(Parent Study: GDC-0853)
kskyvjfghy(ldqketsqar) = bhpsssroxi lxpdtvvyhv (etuvowedhw, wfenwfgity - pgeunhlesu)
-
25 Sep 2020
(Parent Study: Placebo)
kskyvjfghy(ldqketsqar) = ygrmtgdwst lxpdtvvyhv (etuvowedhw, cpnioxznkm - bxzjghwyiq)
Phase 2
496
(GDC-0853 (200mg BID) Cohort 1)
vkoqwawrzw(ndqrieykym) = dysqxahjyv oxdfjddptf (cowolljrcf, zwdnausdnz - jirntpudbm)
-
03 Aug 2020
(GDC-0853 (200mg BID) Cohort 2)
vkoqwawrzw(ndqrieykym) = qvdahvfkxp oxdfjddptf (cowolljrcf, vslywxmwur - cqzlvnmhdi)
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Core Patent

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Clinical Trial

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Approval

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Regulation

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