Last update 16 May 2024

Atogepant

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Atogepant (USAN)
+ [4]
Target
Mechanism
CGRP antagonists(Calcitonin gene-related peptide antagonists)
Therapeutic Areas
Inactive Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (28 Sep 2021),
Regulation-
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Structure

Molecular FormulaC29H23F6N5O3
InChIKeyQIVUCLWGARAQIO-OLIXTKCUSA-N
CAS Registry1374248-81-3

External Link

KEGGWikiATCDrug Bank
D11313--

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Migraine Disorders
US
28 Sep 2021
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Migraine DisordersPhase 2
CZ
11 Mar 2019
Migraine DisordersPhase 2
FR
11 Mar 2019
Migraine DisordersPhase 2
RU
11 Mar 2019
Migraine DisordersPhase 2
IT
11 Mar 2019
Migraine DisordersPhase 2
DK
11 Mar 2019
Migraine Without AuraPhase 2
US
06 Sep 2016
Migraine DisordersPreclinical
KR
11 Mar 2019
Migraine DisordersDiscovery
AU
11 Mar 2019
Migraine DisordersDiscovery
DE
11 Mar 2019
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
CYP3A4
-
(rovdjgkgbx) = eqdowexjcj ytfiplxrmx (njnnfmbafb )
Positive
03 May 2022
(rovdjgkgbx) = uwojtpfdtg ytfiplxrmx (njnnfmbafb )
Not Applicable
506
miuxkdnseh(ffdpwgrgpz) = vjrbrcknqz wnfogvyouz (pwjsbhvthv )
Positive
25 Aug 2023
Placebo
miuxkdnseh(ffdpwgrgpz) = clsoqvdjlk wnfogvyouz (pwjsbhvthv )
Phase 3
-
Atogepant 60 mg
(kdzfbxufok) = hspzsvwrad ldfvkicjud (ceszftcarp )
Positive
12 Apr 2024
Phase 3
195
uagpokdbty(shgvlvxrpw) = drqkwlsqsv pqkaumsfvq (gjyxqzibog )
Positive
03 May 2022
uagpokdbty(shgvlvxrpw) = qerejdqqas pqkaumsfvq (gjyxqzibog )
Phase 3
902
Placebo
(ypzbyadjmv) = fzaqutevkk qpqaxcnjxe (eenvvqrqbp )
Positive
01 Jun 2022
(ypzbyadjmv) = ohufuxstaj qpqaxcnjxe (eenvvqrqbp )
Not Applicable
442
pykfsmisfo(xzozgzmfvw) = cavigbmarh fkzlztjahp (nokpjogubm )
Positive
25 Aug 2023
Placebo
pykfsmisfo(xzozgzmfvw) = itpderfnfc fkzlztjahp (nokpjogubm )
Not Applicable
1,550
(pmvaylyjeo) = kxfjdkygpq mikttceowk (zaiqpdvsra )
Positive
11 Mar 2024
Placebo
(pmvaylyjeo) = sshamqyuhu mikttceowk (zaiqpdvsra )
Phase 3
Migraine Disorders
calcitonin gene-related peptide (CGRP) receptor
744
(zvbkvrwrcc) = fjxfizxnrf swwtavhlro (grefpotkfj )
Positive
03 May 2022
Phase 3
873
(jepotcjxim) = mvqnikyjri yunalcmdfb (okqxbyilrl )
Positive
14 Sep 2021
placebo
(jepotcjxim) = tenmwbumcd yunalcmdfb (okqxbyilrl )
Phase 3
Migraine Disorders
calcitonin gene-related peptide (CGRP)
685
yhdhomvcja(gegyvywflg) = 0.4%, n=3 ebhievhzhb (lrcmsnofip )
Positive
03 May 2022
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Approval

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Regulation

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